Human papillomavirus (HPV) typing as an adjunct to cervical cancer screening

Is Improved Detection of Adenocarcinoma in Situ by Screening a Key to Reducing the Incidence of Cervical Adenocarcinoma?

“…23,24 This is exactly what happened few years earlier for SCC and its precursors, when Pap smear screening was recommended to be replaced or supplemented by HPV testing; that debate still continues. 8,25 Concerning the reduction of incidence of and mortality from AC, the key question is whether the increased detection of AIS is best achieved by (1) cytologic screening; (2) adjunct diagnostic tools, such as HPV testing; or even (3) immunohistochemistry for molecular markers, such as p16 INK4a . [5][6][7]23,24,26 Elucidating this issue has important implications for future screening strategies, which are likely to be different in low and high resource settings.…”

“…[5][6][7]23,24,26 Elucidating this issue has important implications for future screening strategies, which are likely to be different in low and high resource settings. 1,2,4,8,25 An important step forward in validating the concept of AIS as a predominantly screening-detected disease is made in a paper by Mitchell et al, published in this issue of Acta Cytologica. 27 The authors reason that if the increased incidence of AIS 6 were due to improved detection by Pap smear screening, then the screening history of women with diagnosed AIS should be equivalent to that of healthy controls, including the sampling efficiency of endocervical cells in the smears.…”

MicroRNA-10b inhibits proliferation, migration and invasion in cervical cancer cells via direct targeting of insulin-like growth factor-1 receptor

“…The initiation and progression of cervical cancer is a multi-step process, involving multiple factors and the transformation of normal cervical epithelium into cervical intraepithelial neoplasia, which subsequently transforms into invasive cervical cancer (2,3). A number of studies have demonstrated that persistent infection with high-risk human papillomavirus (HPV) serves an important role in the initiation and progression of cervical cancer (4)(5)(6). However, previous studies have shown that HPV infection alone is insufficient to induce malignant changes and that other factors must contribute to cervical carcinogenesis and progression (7,8).…”

Evaluation of colposcopy vs cytology as secondary test to triage women found positive on visual inspection test

“…[12][13][14][15][16] www.indianjcancer.com But these triage modalities are not feasible in a developing country such as India. Cervical cytology screening programs despite its history of success in cancer screening has important limitations, particularly its high false-negative rate, which carries important public health implications.…”