Human papillomavirus in an epidermoid cyst of the sole in a non-Japanese patient

Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia

“…32,33 Currently, a specific defect of cell-mediated immunity in EV patients is believed to facilitate keratinocyte infection by one or more EV HPV types (e.g. HPV 5,8,9,12,14,15,17,[19][20][21][22][23][24][25][36][37][38]47,49). [34][35][36] However, a susceptibility locus to EV mapped to chromosome 17qter region, 37 frequent coinfection with HPV 3, 38 and the rarity of EV-like eruptions in immunodeficient states [39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] indicate that other, nonimmunological factors operate in the development of clinically diagnosable EV infection.…”

“…In previous studies on plantar epidermoid cysts, only the presence of HPV types belonging to group B2 (HPV 4, 48, 50, 60, 65) and A4 (HPV 2-related viruses HPV 2, 27, 57) were analysed. [9][10][11][12][13][14][15][16][17][18][19][20][21] As none of these previous studies analysed the presence of other HPV types, we used consensus primer sets for the detection of HPV types other than these previously detected types. In addition, consensus and type-specific primer sets were used for the detection of group A4 and group B2 HPV types (see Table 1).…”

“…None of the pathological specimens contained HPV DNAs of one of the HPV types (group B2 and group A4) previously detected in cysts. [9][10][11][12][13][14][15][16][17][18][19][20][21] All pathological specimens contained HPV DNAs of cutaneous and EV-associated types. The cysts were found to contain DNA of EV-associated HPV 20 (variant), 24, alb-7 and 80, which is phylogenetically closely related to the EV-associated HPV type 15, but has features of cutaneous HPV types.…”

Does plantar epidermoid cyst with human papillomavirus infection originate from the eccrine dermal duct?

“…PEC has long been assumed to be derived from implantation of an epidermal fragment due to a penetrating injury or other cause. It has recently been suggested that human papillomavirus (HPV) (especially HPV 60) infection may be closely related to the occurrence of PEC 1 . The histogenesis of PEC, especially with HPV infection, has not been well established.…”

Demonstration of Human Papillomavirus Type 60 in an Epidermoid Cyst Developing in the Finger Pulp of the Thumb

“…While epidermoid cysts usually result from infl ammation around pilosebaceous follicles, the cysts developing in the palms and soles, where there are no pilosebaceous follicles, have been assumed to result from implantation of epidermal fragments due to a penetrating injury or other causes. Recently, some palmoplantar epidermal cysts have been reported to be caused by human papillomavirus (HPV) infection [1][2][3][4] . We describe here a Japanese man who developed an epidermal cyst associated with HPV infection at a rare site, i.e., the volar aspect of his right thumb.…”