Human Papillomavirus in Oral Exfoliated Cells and Risk of Head and Neck Cancer

Smith, Elaine; Ritchie, Justine M.; Summersgill, Kurt F.; Hoffman, Henry T.; Wang, Dong Hong; Haugen, Thomas H.; Turek, Lubomír P.

doi:10.1093/jnci/djh074

Cited by 261 publications

(227 citation statements)

References 27 publications

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“…Here, we prefer to the latter classification. Unlike some other studies that analyze for oral cancer other than oropharyngeal site showed low prevalence and non significant association between HPV and oral cancer (Smith et al, 2004), our data indicated that HPV is highly-associated with oral cancer (including oral cavity and oropharyngeal site) and act as an independent risk factor combined with other risk factors such as tobacco and alcohol.…”

Section: Li-li Gan Et Alcontrasting

confidence: 96%

“…A meta-analysis (1988Jemal et al, -2007 showed that the prevalence of HPV DNA in OSCC was 38.1% (Termine et al, 2008). HPV-16 genomic DNA can be detected in 16.5% to 19% of oral cancers in the USA (Schwartz et al, 1998;Smith et al, 2004). While the meta-analysis of Chinese population indicated that the overall rate of HPV-positive OSCC was 58.0% and HPV-16 infection accounted for 47.47% of OSCC (Zhu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Gan¹,

Zhang²,

Guo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Li-li Gan Et Alcontrasting

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Gan¹,

Zhang²,

Guo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Furthermore, to date, only in tonsillar squamous cell carcinoma has the morphology of HPV-positive tumors has suggested that HPV may have a predilection for a population of nonkeratinized squamous cells, easier to penetrated especially in the presence of alcohol, or that the virally transformed cells inhibit keratinization of the tumor cells. 68 This latter hypothesis is consistent with the results of Smith et al, 69 who consider HR HPV infection of oral exfoliated cells to be a risk factor for head-and-neck squamous cell carcinoma, independent of alcohol and tobacco use. Furthermore, Smith et al 70 observed a significant interaction effect between younger age and heavy alcohol use associated with HR HPV cancer status.…”

Section: Discussionsupporting

confidence: 86%

Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: Use of fuzzy neural networks

Muzio

D’Angelo

Procaccini

et al. 2005

Intl Journal of Cancer

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Our aim was to evaluate in oral squamous cell carcinoma (OSCC) the relationship between some cell cycle markers and HPV infection, conditionally to age, gender and certain habits of patients, and to assess the ability of fuzzy neural networks (FNNs) in building up an adequate predictive model based on logic inference rules. Eighteen cases of OSCC were examined by immunohistochemistry for MIB-1, PCNA and survivin expression; presence of HPV DNA was investigated in exfoliated oral mucosa cells by nested PCR (nPCR, MY09-MY11/GP5-GP6), and HPV genotype was determined by direct DNA sequencing. Data were analyzed by traditional statistics (TS) and FNNs. HPV DNA was found in 9/18 OSCCs (50.0 %) without any significant higher risk of HPV infection with respect to the sociodemographic variables considered ( p > 0.2), apart from tobacco smoking, reported in 44.4% of OSCC HPV-positive vs. 100% HPV-negative subjects ( p = 0.029). Regarding cell cycle markers, TS and FNN revealed that survivin was expressed significantly more in HPV-negative than in HPVpositive OSCC [root mean-square error (RMSE) = 5.89 3 10 -6 , % predicted 100.0]; furthermore, smoking played a protective role for survivin expression in HPV-positive cases (OR = 0.019, 95%CI 0.001-0.723, RMSE = 0.20, % of prevision 94.4). FNN, although on a small sample size, allowed us to confirm data by TS and to hypothesize a different cell cycle pattern for HPV-positive vs. HPV-negative OSCC. In the latter cases, the relevance of apoptotic vs. proliferative markers suggested that they may be related to the different supposed outcome of HPV-negative OSCC and that HPV may have a protective role in the expression level of survivin, especially in tobacco smokers. ' 2005 Wiley-Liss, Inc.Key words: human papillomavirus; survivin; oral squamous cell carcinoma; fuzzy neural network; carcinogenesis OSCC is rapidly increasing in incidence and represents the most frequent malignant oral tumor. The incidence of metastasis depends on the degree of cellular differentiation, deep invasion and site of the primary tumor; however, outcome is difficult to predict if only standard clinicopathologic parameters are taken into account. Biologic markers that can help to identify lesions with an aggressive phenotype and worse prognosis need to be identified.Since the majority of human neoplasms are characterized by an imbalance of the regulatory cell cycle control processes, the study of OSCC using the expression of proteins involved in the critical checkpoints of cell apoptosis and growth starts by elucidating the processes of carcinogenesis and appears to have good prognostic value. 1 Indeed, we know that apoptosis, or programmed cell death, and its suppression are involved in the carcinogenesis of several tumors; this process, mediated by caspases and cysteine proteinases present as proenzymes, is inhibited by several proteins, such as those of the Bcl-2 and IAP families. Survivin is an IAP protein, which is abundantly expressed in most solid and hematologic malignancies but undetectable in ...

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“…This is in contrast with the reports in subjects with oral cancer, suggesting that there may be other factors that favor HPV-16 survival in such environment (Smith et al, 2004). Both HPV-16 and HPV-18 were found in one positive sample.…”

Section: Discussioncontrasting

confidence: 86%

Detection of Human Papillomavirus in Normal Oral Cavity in a Group of Pakistani Subjects using Real-Time PCR

Gichki¹,

Buajeeb²,

Doungudomdacha³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Human Papillomavirus in Oral Exfoliated Cells and Risk of Head and Neck Cancer

Abstract: Infection of oral exfoliated cells with HPV-HR types is a risk factor for head and neck cancer, independent of alcohol and tobacco use, and acts synergistically with alcohol consumption. HPV testing of an oral rinse may be predictive of an HPV-related head and neck cancer.

Cited by 261 publications

References 27 publications

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: Use of fuzzy neural networks

Detection of Human Papillomavirus in Normal Oral Cavity in a Group of Pakistani Subjects using Real-Time PCR

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