Human Papillomavirus in Sinonasal Malignancies

Hebsgaard, M.; Eriksen, P.; Ramberg, I.; Buchwald, Christian von

doi:10.1007/s40136-023-00448-3

Cited by 3 publications

(3 citation statements)

References 68 publications

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“…Furthermore, a new unique histological tumor type has been described as HPV-related multi-phenotypic sinonasal carcinoma [33]. Studies have also reported that HPV related sino-nasal malignancies have a decreased mortality rate as compared to HPV-negative tumors, just like what has already been seen and described in other head and neck carcinomas [33]. Over expression of p53 may also serve as a marker for malignant transformation in cases of inverted papilloma [2].…”

Section: Predictive Markers For Malignancymentioning

confidence: 87%

“…So despite repeated detection of HPV in inverted papilloma cases, a definitive causal association still remains at best controversial [33]. Furthermore, a new unique histological tumor type has been described as HPV-related multi-phenotypic sinonasal carcinoma [33]. Studies have also reported that HPV related sino-nasal malignancies have a decreased mortality rate as compared to HPV-negative tumors, just like what has already been seen and described in other head and neck carcinomas [33].…”

Section: Predictive Markers For Malignancymentioning

confidence: 99%

“…Also, the usefulness of p16 as a surrogate marker of HPV infection and definite prediction of malignant transformation in inverted papilloma cases also needs more investigation [32]. So despite repeated detection of HPV in inverted papilloma cases, a definitive causal association still remains at best controversial [33]. Furthermore, a new unique histological tumor type has been described as HPV-related multi-phenotypic sinonasal carcinoma [33].…”

Section: Predictive Markers For Malignancymentioning

confidence: 99%

See 2 more Smart Citations

Inverted Sinonasal Papilloma: Update and Literature Review

Awosusi,

Rahman

2023

AJMAH

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Inverted sinonasal papilloma is a benign neoplasm that usually affects the intra-nasal cavity and adjacent paranasal sinuses. Inverted papillomas have three unique features that distinguishes them from other sinonasal tumors including; a propensity for local destructive growth, a high rate of recurrence and risk of malignant transformation. The reported yearly incidence is about 0.6 to 1.5 cases per 100,000 people per year and they usually account for 0.5% to 4% of all nasal tumors. They occur at the following locations; both lateral nasal walls, ethmoidal cells, maxillary sinus, the frontal sinus, sphenoid sinuses and the nasal septum in decreasing order. It occurs most commonly in the fifth and sixth decades of life with a male-to-female ratio of 2-3:1. Inverted papilloma can arise from the entire Schneiderian membrane and molecular genetics have confirmed that it is an actual neoplasm that arises from a single progenitor cell. Most cases are diagnosed from clinical history and thorough physical examination. However, complete removal of all affected tissue with thorough histopathological evaluation is recommended to ensure a correct diagnosis. While there is yet no established pathognomonic histopathological feature to predict recurrence with all certainty, there is ongoing investigation for predictive markers of recurrence. Smoking seems to be a recognized risk factor for developing multiple recurrences and there is evidence that the presence of HPV serotypes 16 and 18 could be predictive of malignant transformation. The main aim of treatment is to achieve compete surgical resection and to prevent recurrence and malignant transformation. A period of clinical follow up is recommended after treatment. The aim of this review is to provide a comprehensive and updated overview of the clinical presentation, diagnosis, management and prognosis of this unique lesion.

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Section: Predictive Markers For Malignancymentioning

confidence: 87%

Section: Predictive Markers For Malignancymentioning

confidence: 99%

Section: Predictive Markers For Malignancymentioning

confidence: 99%

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Inverted Sinonasal Papilloma: Update and Literature Review

Awosusi,

Rahman

2023

AJMAH

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OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking

Panthong,

Pientong,

Nukpook

et al. 2024

Biology

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Sinonasal squamous cell carcinoma (SNSCC) is a rare tumor with high mortality and recurrence rates. However, SNSCC carcinogenesis mechanisms and potential therapeutic drugs have not been fully elucidated. This study investigated the key molecular mechanisms and hub proteins involved in SNSCC carcinogenesis using proteomics and bioinformatic analysis. Dysregulated proteins were validated by RT-qPCR in SNSCC and nasal polyp (NP) tissues. Proteomic analysis revealed that differentially expressed proteins were clustered using MCODE scores ≥ 4 into three modules. The specific hub proteins in each module were analyzed in carcinogenesis pathways using STRING, highlighting potential mechanisms of histone modification and spliceosome dysregulation. Spliceosome components SNRNP200 and SF3A3 were significantly downregulated in SNSCC by RT-qPCR. Web-based applications L1000CDS2 and iLINCS were applied to identify 10 potential repurposable drugs that could reverse the gene expression pattern associated with SNSCC. Docking studies of TAF1, a protein in histone modification, with these 10 small molecule inhibitors indicated OSI-027 to be the most promising due to its strong binding interactions with key residues. These findings suggest that hub proteins involved in the underlying mechanism of SNSCC carcinogenesis may serve as valuable targets for drug development, with OSI-027 emerging as a novel candidate against TAF1 in SNSCC.

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The Potential Role of the Microbiome in the Pathogenesis of Nasal Tumors: A Comprehensive Review

Loperfido,

Rizzo,

Fionda

et al. 2024

Medicina

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Cancers of the nose, and especially the nose vestibule, represent a significant challenge for clinicians due to their rarity, the intricate nature of surrounding vital structures, the nonspecific early symptoms, and the etiological factors that are not completely understood. Emerging research suggests that alterations in the nasal microbiome, also known as microbial dysbiosis, may contribute to the pathogenesis of those malignancies through mechanisms involving chronic inflammation, immune modulation, and cellular changes. The aims of this paper are to review the current literature covering the nasal microbiome’s role in carcinogenesis, particularly in the context of squamous cell carcinoma, and to explore how microbial dysbiosis might foster a pro-tumorigenic environment. It further discusses potential future directions for research and therapeutic approaches.

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Human Papillomavirus in Sinonasal Malignancies

Cited by 3 publications

References 68 publications

Inverted Sinonasal Papilloma: Update and Literature Review

Inverted Sinonasal Papilloma: Update and Literature Review

OSI-027 as a Potential Drug Candidate Targeting Upregulated Hub Protein TAF1 in Potential Mechanism of Sinonasal Squamous Cell Carcinoma: Insights from Proteomics and Molecular Docking

The Potential Role of the Microbiome in the Pathogenesis of Nasal Tumors: A Comprehensive Review

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