Human papillomavirus in tonsillar squamous cell carcinomas from Guatemala and Brazil

Piña, Alicia Rumayor; Jimenez, Laísa Simakawa; Mariano, Fernanda Viviane; Andrade, Bruno Augusto Benevenuto de; Carlos, Román; Altemani, Albina; Almeida, Oslei Paes de

doi:10.1016/j.oooo.2015.12.002

Cited by 10 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…in Brazil in 2016, where 75 % of the study population had positive presence of HPV 16 and 25% had negative. 25,26 This finding is also in contrast to a study done by Zafareo, M.E. in 2016 in USA where 30% of the total study population has positive HPV 16.…”

Section: Discussioncontrasting

confidence: 70%

Human papilloma virus prevalence and its correlation with clinical presentation and histological grading in oral squamous cell carcinoma.

Ahmed¹,

Shahid²,

Shafique³

et al. 2021

TPMJ

View full text Add to dashboard Cite

Objectives: The objectives of this study were to determine the prevalence of Human Papilloma virus 16 in patients with oral squamous cell carcinoma presenting at Isra University Hospital and to correlate the existence of Human Papilloma virus 16 in squamous cell carcinoma with clinical presentation, habits and histological grading. Study Design: Interventional Study. Setting: Department of Oral Surgery, Isra Dental College Hospital. Period: July 2017 to December 2017. Material & Methods: A sample of 60 patients presenting were selected by non-probability purposive sampling. Patients reporting to Isra Dental College, Oral Surgery OPD Isra University during the study period with clinical suspicion of Oral Squamous Cell Carcinoma were included. Results: Age category was from 20 till 60+ years of age whereas age group of 40-49 (36.7%) was the most frequent age in the study population followed by 30-39 (30%) years and 50-59 (23.3%) years of age respectively. The mean and standard deviation was 43.35 ± 10.156 respectively. Maximum numbers of people were seen to have more than one habit i.e. they were using guthka with smoking or areca nut with guthka and smoking etc. areca nut, cigarette smoking and guthka were among the others most used. The mean was 6.32 with standard deviation of 2.954. Most of the patients had submucous fibrosis on the right side of buccal vestibule 24 (40%) and 22 (36.7%) had submucous fibrosis on the left side of buccal vestibule. 56 (93.3%) of the patients had well differentiated squamous cell carcinoma whereas 4 (6.7%) has moderately differentiated squamous cell carcinoma. No patients were seen to have poorly differentiated squamous cell carcinoma. Conclusion: In conclusion, the Prevalence of HPV 16 in our study was found to be 11.7%. There was no association between habits and histological grading with Human Papillomavirus 16 in patient with oral squamous cell carcinoma. But there was association between HPV16 and clinical presentation of OSCC because of p-value (.015) which was significant.

show abstract

Section: Discussioncontrasting

confidence: 70%

Human papilloma virus prevalence and its correlation with clinical presentation and histological grading in oral squamous cell carcinoma.

Ahmed¹,

Shahid²,

Shafique³

et al. 2021

TPMJ

View full text Add to dashboard Cite

show abstract

“…In contrast, patients with HPV-negative head and neck tumors have a higher consumption of tobacco and alcohol. 27 …”

Section: Discussionmentioning

confidence: 99%

Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status

et al. 2022

Self Cite

View full text Add to dashboard Cite

Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in the immune response against human papillomavirus (HPV) infection, and represent a therapeutic target in cancer. Objective: To identify and quantify DCs in tonsillar squamous cell carcinoma (TSCC) under the influence of HPV infection. Methodology: CD1a and CD83 antibodies were used to identify immature dendritic cells and mature dendritic cells by immunohistochemistry in 33 primary TSCC and 10 normal tonsils (NTs), respectively. For the TSCC samples, the number of DCs per area was evaluated in the intra- and peritumoral compartments. For the NTs, the quantification of DCs was evaluated in the intra- and peritonsillar compartments. HPV detection methods were determined according to the ASCO Clinical Practice Guidelines from the College of American Pathologists Guideline (2018). Results: There were fewer intratumoral CD1a+ DCs in the HPV-positive and HPV-negative TSCC groups than in the NT group (p<0.05). In the peritumoral compartment, there were fewer CD83+ DCs in the HPV-positive and HPV-negative TSCC groups than in the NT group (p<0.001). The quantification of DCs subtypes showed no statistical differences between HPV-positive and HPV-negative TSCC groups (p>0.137). Patients with HPV-positive TSCC had significantly better overall survival rate than those with HPV-negative TSCC (p=0.004). Conclusion: Tumor activity contributes to DC depletion regardless of intralesional HPV positivity. An improved prognosis has been reported in patients with HPV-positive TSCC.

show abstract

“…13 longitudinal studies with 2371 participants were included in this study [6,9,10,[16][17][18][19][20][21][22][23][24][25]. These studies were conducted in different Brazilian regions, and most of the studies were carried out in the Southeast region.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Human Papillomavirus (HPV) Prevalence in Oropharynx Squamous Cell Carcinomas (OPSCC) in Brazil: A Systematic Review with Meta-analysis

Ferreira¹,

Rossin²,

Santos³

et al. 2023

JAMMR

View full text Add to dashboard Cite

Background: Oropharynx squamous cell carcinomas (OPSCC) are an important public health problem. Our study aimed to conduct a systematic review with a metanalysis of the human papillomavirus (HPV) prevalence in OPSCC in Brazil. The aim of our study was to conduct a systematic review with metanalysis about the level of Knowledge of the relation between human papillomavirus (HPV) and OPSCC among university students Methodology: We conducted a systematic review according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched MEDLINE/PubMed, SCOPUS, EMBASE and Lilacs for articles published up to March 2023. Results: A total of 260 studies were retrieved with our search strategy, in addition, we included 3 articles manually. After removing duplicate articles, 156 studies remained. Reading the titles and abstracts of these studies, 34 studies were eligible to read the full article. After reading the full text of the selected articles, we excluded 21 articles for reasons such as: no access to the full text (n = 2), literature reviews, systematic reviews, case studies (n = 3), conference proceedings, thesis (n = 6), studies with few participants (n = 2) and studies that did not address the topic (n=8). There were 13 studies left that were included in this systematic review. Conclusion: This study revealed a pooled prevalence of 18% of HPV in OPSCC in Brazil

show abstract

Human papillomavirus in tonsillar squamous cell carcinomas from Guatemala and Brazil

Cited by 10 publications

References 27 publications

Human papilloma virus prevalence and its correlation with clinical presentation and histological grading in oral squamous cell carcinoma.

Human papilloma virus prevalence and its correlation with clinical presentation and histological grading in oral squamous cell carcinoma.

Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status

Human Papillomavirus (HPV) Prevalence in Oropharynx Squamous Cell Carcinomas (OPSCC) in Brazil: A Systematic Review with Meta-analysis

Contact Info

Product

Resources

About