Human papillomavirus infection and autoimmune disorders: a tertiary center experience

Abstract

This study aimed to investigate the relationship between HPV and autoimmune disorders. We retrospectively evaluated 62 women who had HPV-DNA positivity in terms of autoimmune disorders (autoimmune antibody positivity, chronic inflammatory diseases and autoimmune diseases). The patients were divided into two groups according to autoimmune disorder positivity (autoimmune positive (n = 30), autoimmune negative (n = 32)) and compared with each other in terms of single and multiple HPV-DNA types, high and low-risk HPV-DNA types, and Pap smear findings. We determined that 48.4% of the HPV-DNA positive patients had autoimmune disorders. We found that 15 of 62 (24.2%) women had more than one type of HPV and HPV type 16 was the dominant type in this study (58.2%). A total of 27.4% of HPV-DNA positive patients had abnormal cytological findings. There was no statistically significant difference between autoimmune groups in terms of the presence of high-risk HPV types, multiple HPV types and abnormal cytological findings (P = 0.531, P = 0.558 and P = 0.234, respectively). The prevalence of autoimmune disorders was high among HPV-DNA positive women. On the other hand, the rate of high-risk HPV type positivity, multiple HPV infections and cytopathological findings were similar between the autoimmune positive and negative groups.

Patolojik servikovajinal simirler ve idrar yolu enfeksiyonu arasında bir ilişki var mıdır?

“…Abnormal cytological findings include atypical squamous cells of undetermined significance (ASCUS), atypical squamous cells, low-grade squamous intraepithelial lesion (LSIL), and high-grade squamous intraepithelial lesion (HSIL). Human papillomavirus (HPV) is the main cause of these cytopathological findings (17). There was no previous study investigating the relationship between these changes and UTIs.…”

How mesenchymal stem cell conditioned media affect the HeLa cells on Wnt/beta-catenin signaling, Notch-1 signaling, and apoptosis?

“…Pap smear and Human papillomavirus (HPV)-DNA screening programs, as well as the vaccination, reduce cervical cancer incidence and mortality in developed countries. However, the mortality in developing countries is still remarkably high [2]. The therapy modality (surgery combined with radiotherapy and/or chemotherapy) is depicted by the stage, size, location, and type of cervical cancer [3].…”

Application of the Bethesda system of reporting for cervical cytology to evaluate human papilloma virus induced changes in oral leukoplakia, oral squamous cell carcinoma, and oropharyngeal squamous cell carcinoma: A cytomorphological and genetic study

“…12 The Bethesda system for reporting cervical cytology (TBS) was proposed in 1988 for the interpretation of cervicovaginal smears has been widely accepted by many pathologists from the different parts of world. 13 However, diagnosis by oral cytology has been widely performed based on the Papanicolaou grading system, and not by TBS. 13 So we aimed to establish the applicability of LBC in the early detection of cytological changes in OL, oral and OPSCC in accordance with TBS.…”

“…13 However, diagnosis by oral cytology has been widely performed based on the Papanicolaou grading system, and not by TBS. 13 So we aimed to establish the applicability of LBC in the early detection of cytological changes in OL, oral and OPSCC in accordance with TBS. We also correlated the non-classical cytomorphological alterations shown by HPV16 positive and negative oral as well as oropharyngeal lesions.…”

“…Moreover, there has been no established specific diagnostic guideline for oral cytology 12 . The Bethesda system for reporting cervical cytology (TBS) was proposed in 1988 for the interpretation of cervicovaginal smears has been widely accepted by many pathologists from the different parts of world 13 . However, diagnosis by oral cytology has been widely performed based on the Papanicolaou grading system, and not by TBS 13 …”