Human papillomavirus infection and intrauterine growth restriction: a data-linkage study

Ford, Judith H.; Li, Ming; Scheil, Wendy; Roder, David

doi:10.1080/14767058.2017.1378330

Cited by 13 publications

(10 citation statements)

References 20 publications

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“…Infectious pathogens during pregnancy have repeatedly been indicated to be responsible for adverse pregnancy outcomes, as well as a number of severe neonatal sequelae [82]. However, the involvement of HPV in the evolution and outcome of pregnancy is not quite clear, with studies reporting somewhat contradictory results: while some authors saw no relationship [83,84], others highlighted various adverse pregnancy outcomes, ranging from preterm birth [85], spontaneous abortion [86], the premature rupture of membranes [87], and pregnancy-induced hypertensive disorders [88] to intrauterine growth restriction [89], low birth weight [90], and fetal death [88]. A degree of contradiction between studies is, nevertheless, to be expected, if one takes into consideration the different sizes of the study samples, the more or less rigorous methodology, and the occasional lacking values for different variables (Table 2).…”

Section: Hpv and Pregnancy Outcomesmentioning

confidence: 99%

“…Following this small study, Ford et al later investigated this association in their data-linkage study, comprising 31,827 women. They found that mothers with abnormal Pap smears were at an increased risk of giving birth to babies beneath the third percentile, with very low birth weight (VLBW), independent of other risk factors [89].…”

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

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Maternal HPV Infection: Effects on Pregnancy Outcome

Condrat

Filip

Gherghe

et al. 2021

Viruses

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The human papilloma virus (HPV) infection, caused by a ubiquitous virus typically transmitted through the direct contact of infected organs, either through the skin or mucosa, is the most common sexually transmitted infection, placing young women at a high risk of contracting it. Although the vast majority of cases spontaneously clear within 1–2 years, persistent HPV infection remains a serious concern, as it has repeatedly been linked to the development of multiple malignancies, including cervical, anogenital, and oropharyngeal cancers. Additionally, more recent data suggest a harmful effect of HPV infection on pregnancy. As the maternal hormonal environment and immune system undergo significant changes during pregnancy, the persistence of HPV is arguably favored. Various studies have reported an increased risk of adverse pregnancy outcomes among HPV-positive women, with the clinical impact encompassing a range of conditions, including preterm birth, miscarriage, pregnancy-induced hypertensive disorders (PIHD), intrauterine growth restriction (IUGR), low birth weight, the premature rupture of membranes (PROM), and fetal death. Therefore, understanding the mechanisms employed by HPV that negatively impact pregnancy and assessing potential approaches to counteract them would be of interest in the quest to optimize pregnancy outcomes and improve child survival and health.

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Section: Hpv and Pregnancy Outcomesmentioning

confidence: 99%

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

Maternal HPV Infection: Effects on Pregnancy Outcome

Condrat

Filip

Gherghe

et al. 2021

Viruses

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“…Focusing on specific viral groups rather than the collective virome, vaginal HPV infections have been linked to SGA and low birth weight in observational studies, independently of other risk factors [99,100]. In silico analyses have revealed significant associations between invasive neonatal-infecting GBS isolates and harbouring of a specific group of prophages within their genomes [39].…”

Section: Adverse Birth Outcomesmentioning

confidence: 99%

The Vaginal Virome—Balancing Female Genital Tract Bacteriome, Mucosal Immunity, and Sexual and Reproductive Health Outcomes?

Happel

Varsani

Balle

et al. 2020

Viruses

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Besides bacteria, fungi, protists and archaea, the vaginal ecosystem also contains a range of prokaryote- and eukaryote-infecting viruses, which are collectively referred to as the “virome”. Despite its well-described role in the gut and other environmental niches, the vaginal virome remains understudied. With a focus on sexual and reproductive health, we summarize the currently known components of the vaginal virome, its relationship with other constituents of the vaginal microbiota and its association with adverse health outcomes. While a range of eukaryote-infecting viruses has been described to be present in the female genital tract (FGT), few prokaryote-infecting viruses have been described. Literature suggests that various vaginal viruses interact with vaginal bacterial microbiota and host immunity and that any imbalance thereof may contribute to the risk of adverse reproductive health outcomes, including infertility and adverse birth outcomes. Current limitations of vaginal virome research include experimental and analytical constraints. Considering the vaginal virome may represent the missing link in our understanding of the relationship between FGT bacteria, mucosal immunity, and adverse sexual and reproductive health outcomes, future studies evaluating the vaginal microbiome and its population dynamics holistically will be important for understanding the role of the vaginal virome in balancing health and disease.

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“…2 , Evidence from in situ hybridization or the HPV typing array results. 3 , Samples selected based on the presence or absence of high-risk HPV DNA by in situ hybridization. BMI, body mass index; HR, high-risk, PET, preeclampsia; FGR, fetal growth restriction; HDP, hypertension disorders in pregnancy.…”

Section: %mentioning

confidence: 99%

“…Human papillomavirus (HPV) is a prevalent infection amongst women of reproductive age [1]. During pregnancy, HPV infection rates are higher [1,2] and are associated with early and late-pregnancy complications, including PET, fetal growth restriction (FGR), and miscarriages [3][4][5][6][7][8][9][10][11][12][13][14][15][16]. However, an association between HPV and pregnancy complications is not found universally, and whether HPV is causative of pregnancy complications remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus E6/E7 Expression in Preeclampsia-Affected Placentae

et al. 2020

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Whether HPV is causative of pregnancy complications is uncertain. E6 and E7 affect functions underling preeclampsia (PET) in cultured trophoblasts, but whether E6 and E7 is produced in the placenta is uncertain. Here, we investigated whether E6/E7 was expressed in the placentae from pregnancies with PET, other pregnancy complications (fetal growth restriction (FGR) and diabetes mellitus), and uncomplicated pregnancies. Placental tissues collected from two geographical locations were subjected to RNAscope analyses of high- and low- risk E6/E7, and individual HPV types identified using an HPV array. High-risk E6/E7 expression was increased in both PET cohorts, (81% and 86% of patients positive for high-risk HPV DNA compared to 13% of control patients). Various HPV types were identified. Although HPV 18 was the most frequent in all cohorts, the majority of individuals had multiple HPV types (55% of the PET compared to 25% of the control cohort). Further evidence that E6 and E7 is present early when placental pathology underlying preeclampsia is established, is provided with the finding of high-risk E6/E7 in the first-trimester placenta anchoring trophoblast. In conclusion, E6/E7 expression and multiple HPV types were frequent in placentae from preeclampsia-complicated pregnancies.

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Human papillomavirus infection and intrauterine growth restriction: a data-linkage study

Abstract: Mothers with a positive Pap smear have an increased risk of IUGR, especially for VLBW, which is independent of other risk factors. The results confirm previous findings in a small study and emphasise the need to consider the risks of both cancer and IUGR in all HPV vaccination programs.

Cited by 13 publications

References 20 publications

Maternal HPV Infection: Effects on Pregnancy Outcome

Maternal HPV Infection: Effects on Pregnancy Outcome

The Vaginal Virome—Balancing Female Genital Tract Bacteriome, Mucosal Immunity, and Sexual and Reproductive Health Outcomes?

Human Papillomavirus E6/E7 Expression in Preeclampsia-Affected Placentae

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