Human papillomavirus infection and ocular surface disease (Review)

Chalkia, Aikaterini; Bontzos, Georgios; Spandidos, Demetrios Α.; Detorakis, Εfstathios T.

doi:10.3892/ijo.2019.4755

Cited by 32 publications

(42 citation statements)

References 91 publications

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“…Real-time PCR can eliminate the risk of carryover contamination. Our results showed no HPV DNA in the 116 pterygium swabs, consistent with nine studies that also showed no HPV DNA in pterygia using different HPV detection techniques 3 , 22 . Moreover, Tulvatana et al studied HPV prevalence in ocular surface squamous neoplasia in Thailand and found no HPV DNA 23 .…”

Section: Discussionsupporting

confidence: 92%

“…Many studies have found HPV DNA in pterygium samples using different techniques including PCR, Southern blotting, immunohistochemistry, in situ hybridization, and the Hybrid capture assay II. HPV prevalence varied among these studies, ranging from 0%–100%, and the strains of detected HPV DNA also differed among studies 3 , 20 . Thus, no consensus has been reached regarding HPV as a possible pathogenic cofactor.…”

Section: Discussionmentioning

confidence: 96%

“…HPV is a non-enveloped virus, with double-stranded circular DNA. It commonly causes infections in the mucous membranes of the anogenital area and oropharynxx 3 . Several studies have reported the involvement of HPV infections, an increased recurrence risk rate, and more aggressive ophthalmic pterygia 3 , 8 .…”

Section: Introductionmentioning

confidence: 99%

“…It commonly causes infections in the mucous membranes of the anogenital area and oropharynxx 3 . Several studies have reported the involvement of HPV infections, an increased recurrence risk rate, and more aggressive ophthalmic pterygia 3 , 8 . Moreover, transmission of genital HPV infections via contaminated fingers is thought to be strongly associated with ocular HPV infections 3 , 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported the involvement of HPV infections, an increased recurrence risk rate, and more aggressive ophthalmic pterygia 3 , 8 . Moreover, transmission of genital HPV infections via contaminated fingers is thought to be strongly associated with ocular HPV infections 3 , 9 . However, this hypothesis remains questionable and controversial 10 .…”

Section: Introductionmentioning

confidence: 99%

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Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye

Uthaithammarat

Kasetsuwan

Chongpison

et al. 2021

Sci Rep

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This study evaluated human papillomavirus’s (HPV) role in pterygium pathogenesis, its autoinoculation from genitalia to ocular surface, potential cytokines involved, and crosstalk cytokines between pterygium and dry eye (DE). This cross-sectional study enrolled 25 healthy controls (HCs) and 116 pterygium patients. Four subgroups of pterygium and DE were used in cytokine evaluations. Conjunctival and pterygium swabs and first-void urine samples (i.e., genitalia samples) were collected for HPV DNA detection using real-time polymerase chain reaction. Tear cytokines interleukin (IL)-6, IL-18, and vascular endothelial growth factor (VEGF) in tears were evaluated. No HPV DNA was detected in conjunctival or pterygium swabs. No association was found between HPV DNA in urine samples and that from conjunctival or pterygium swabs. Tear VEGF levels were significantly higher in pterygium patients than in HCs, with no markedly different levels between primary and recurrent pterygia. Tear IL-6, IL-18, and tear VEGF were significantly higher in participants with DE, regardless of pterygium status. In conclusion, HPV infection was not a pathogenic factor of pterygia. The hypothesis of HPV transmitting from the genitals to ocular surfaces was nullified. Tear VEGF was involved in both pterygia and DE, whereas tear IL-6 and IL-18 played roles only in DE.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye

Uthaithammarat

Kasetsuwan

Chongpison

et al. 2021

Sci Rep

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A man with an ocular mass

Zitek

Luschitsky

2022

JACEP Open

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Association between HPV detection in swab samples and tissue specimens and ophthalmic pterygium recurrence

Chalkia

Tseliou

Bontzos

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose To investigate the presence of HPV on the ocular surface after surgical excision of HPV infected pterygia and the possible correlation of HPV with pterygium postoperative recurrence. Materials and methods Both exfoliative pterygium swab samples and respective tissue specimens were received and analyzed with real-time PCR for the detection of HPV-infected pterygia. In addition, swab samples from patients that had HPV-infected pterygia with no recurrence after 1 year of follow-up, as well as swab samples from patients with healthy conjunctiva, were analyzed. Results Forty eyes with pterygium of 40 patients and 40 eyes with normal conjunctiva were included in the study. HPV virus was detected in the tissue specimens of 11 patients (27.5%) and in the swabs of 9 patients (22.5%). The HPV subtypes detected were 33, 39, 45, 56, 59, 66, and 68. The swab test had sensitivity of 81.82% and 100% specificity. In 15 (43%) patients, a bare sclera technique was used for pterygium removal and eleven of these patients showed recurrence of the disease. Surgical excision with use of autologous conjunctival graft was performed in twenty patients and five of them had recurrence. Patients with recurrent disease were 12.41 times more likely to have an HPV-infected pterygium (p = 0.031). Furthermore, from the 11 HPV positive patients, six had no recurrence, 1 year after surgery. In five of them, a swab sample was taken from the site of the surgical excision 1 year after surgery and real-time PCR was negative for HPV presence. Conclusion Persistence of HPV infection seems to be correlated with postoperative pterygium recurrence. Further investigation with the use of the minimally invasive proposed swab technique may contribute in the understanding of pterygium pathogenesis and in the development of a more efficient treatment planning.

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Human papillomavirus infection and ocular surface disease (Review)

Cited by 32 publications

References 91 publications

Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye

Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye

A man with an ocular mass

Association between HPV detection in swab samples and tissue specimens and ophthalmic pterygium recurrence

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