Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis

“…One of them included longitudinal studies: a nested case-control and a cohort study with high causality [24]. According to subgroup analyses from several trials, the HPV infection constitutes a risk for lung cancer, especially in non-smokers, similar to the findings in head and neck cancers, females and Asian race [22,24,82]. Additionally considering HPV affinity to squamous cells, HPV infection constitutes a risk for squamous cell lung cancer; however, other histologic subtypes including ADC and SCLC have also been related to HPV infection [23,24,94].…”

Section: Hpv In Lung Cancer Clinical Information and Perspectivementioning

confidence: 96%

“…Likewise, recent studies have demonstrated a significantly increased risk of acquiring lung cancer in non-smokers who are exposed to HPV infection (OR 5.32; 95% CI 1. 75-16.17) [22,23]. Figure 1 depicts a meta-analysis of recent studies evaluating the association between HPV infection and lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Infection and Lung Cancer

Cardona¹,

Ruíz-Patiño²,

Ricaurte³

et al. 2019

Current Perspectives in Human Papillomavirus

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Lung cancer continues to be the most common neoplasia and represents the leading cause of cancer-related death in the world. Nonetheless, contrary to expected projections, the decrease in incidence expected by decrease in tobacco exposure has been partially halted due to an increasing amount of lung cancer cases in nonsmokers, particularly in female patients. This led to the development of new hypotheses in terms of lung cancer etiology, including the involvement of oncogenic viruses such as the human papillomavirus (HPV). HPV role in the pathophysiology of lung cancer, including adenocarcinoma and squamous cell carcinoma, is currently under research. Exposure to HPV, and the resulting infection, can occur in several possible ways, including sexual transmission and airborne fomites. Main pathogenic occurrences include alterations in inhibition of p53 and retinoblastoma. This chapter presents the current evidence as to the role of HPV in the development of lung cancer, methods to establish HPV infection, and also explores the role of predisposing factors, as well as immunological and inflammatory factors in nonsmokers. Additionally, the role of other molecular factors, such as EGFR, interleukins 6 and 10, and others, is discussed. Finally, future perspectives in this new paradigm of lung cancer in nonsmokers are broadly reviewed.

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“…An “adaptive” meta-analysis also revealed a significant effect of HPV infection in lung cancer risk in East Asian women and never smokers [34]. …”

Section: Non-smoking East Asian Female Lung Adenocarcinomamentioning

confidence: 99%

The most important questions in cancer research and clinical oncology

Wee

Poh

2017

Chin J Cancer

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Specific research foci: (1) Mouse models of gamma-herpes virus-68 (γHV-68) and polyomavirus (PyV) infections during neonatal versus adult life. (2) For human papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)—(a) Asking the question: Is oral sex a powerful carcinogen? (b) Examining the evidence for the vertical transmission of HPV infection. (c) Examining the relationship between HPV and Epstein–Barr virus (EBV) infections and nasopharyngeal cancer (NPC) in West European, East European, and East Asian countries. (d) Examining the association between HPV-positive OPC and human leukocyte antigen (HLA). (3) For non-smoking East Asian female lung adenocarcinoma—(a) Examining the incidence trends of HPV-positive OPC and female lung adenocarcinoma according to birth cohorts. (b) Examining the association between female lung adenocarcinoma and HPV. (c) Examining the associations of lung adenocarcinoma with immune modulating factors. (4) For triple-negative breast carcinoma (TNBC) in East Asians—(a) Examining the association between TNBC and HPV. (b) Examining the unique epidemiological characteristics of patients with TNBC. A summary “epidemiological” model tying some of these findings together.

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Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis

Cited by 24 publications

References 51 publications

Oral HPV prevalence in general healthy dental patients and patients with oral and oropharyngeal neoplasms in Bulgaria

Oral HPV prevalence in general healthy dental patients and patients with oral and oropharyngeal neoplasms in Bulgaria

Human Papillomavirus Infection and Lung Cancer

The most important questions in cancer research and clinical oncology

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