Human Papillomavirus Infection and Time to Progression and Regression of Cervical Intraepithelial Neoplasia

Schlecht, Nicolas F.

doi:10.1093/jnci/djg037

Cited by 288 publications

(228 citation statements)

References 23 publications

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“…Therefore, we started from the date of diagnosis and stepped backwards in the screening history until reaching a smear fulfilling the criteria of (a) being negative itself, (b) being preceded by a normal smear or being preceded by an abnormal smear taken at least 3 years earlier, or being the first registered smear. The time span of 3 years was chosen to increase the likelihood of spontaneous regression of the preceding lesion (Schlecht et al, 2003), and consequently decreasing the risk of selecting falsenegative smears. Secondly, up to three smears per woman were chosen from cases and controls at random to increase the chance of including an existing HPV infection.…”

Section: Methodsmentioning

confidence: 99%

High viral loads of human papillomavirus predict risk of invasive cervical carcinoma

et al. 2005

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Section: Methodsmentioning

confidence: 99%

High viral loads of human papillomavirus predict risk of invasive cervical carcinoma

et al. 2005

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“…[52][53][54][55][56] In the ALTS trial, the 2-year cumulative incidence of CIN3 among women with LSIL varied between 14 and 18%. 57 One repeat Pap smear at cut-off ASCUS had a sensitivity of 91% and resulted in referral of 81% of women.…”

Section: Management Of Women With Lsilmentioning

confidence: 99%

European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1

et al. 2008

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European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1The current paper presents the first part of Chapter 6 of the second edition of the European Guidelines for Quality Assurance in Cervical Cancer Screening. It provides guidance on how to manage women with abnormal cervical cytology. Throughout this article the Bethesda system is used for cervical cytology terminology, as the European guidelines have recommended that all systems should at least be translated into that terminology while cervical intraepithelial neoplasia (CIN) is used for histological biopsies (Cytopathology 2007; 18:213-9). A woman with a high-grade cytological lesion, a repeated low-grade lesion or with an equivocal cytology result and a positive human papillomavirus (HPV) test should be referred for colposcopy. The role of the colposcopist is to identify the source of the abnormal cells and to make an informed decision as to whether or not any treatment is required. If a patient requires treatment the colposcopist will decide which is the most appropriate method of treatment for each individual woman. The colposcopist should also organize appropriate follow-up for each woman seen. Reflex testing for high-risk HPV types of women with atypical squamous cells (ASC) of undetermined significance with referral for colposcopy of women who test positive is a first option. Repeat cytology is a second possibility. Direct referral to a gynaecologist should be restricted to special circumstances. Follow-up of low-grade squamous intraepithelial lesion is more difficult because currently there is no evidence to support any method of management as being optimal; repeat cytology and colposcopy are options, but HPV testing is not sufficiently selective, unless for older women. Women with high-grade squamous intraepithelial lesion (HSIL) or atypical squamous cells, cannot exclude HSIL (ASC-H) should be referred without triage. Women with glandular lesions require particular attention. In a subsequent issue of Cytopathology, the second part of Chapter 6 will be presented, with recommendations for management and treatment of histologically confirmed intraepithelial neoplasia and guidance for follow-up of special cases such as women who are pregnant, postmenopausal or immunocompromised.

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“…HPV typing provides important data for the distinction between high and low risk. Women positive for high-risk HPV genotypes within a short time proceed from atypical squamous cells of undetermined significance (ASCUS) to more severe lesions and the lesions are more extensive compared with low-risk HPV genotypes (Schlecht et al, 2003). Hence, cervical cancer prevention programs could integrate molecular HPV testing either as a screening tool, triage policies of women with borderline or mildly dyskaryotic (BMD) smears and post-treatment observation (Snijders et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

High-risk Human Papillomavirus Genotype Detection by Electrochemical DNA Chip Method

Chansaenroj

Theamboonlers²,

Chinchai³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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According to a cohort study, HPV cumulative incidence rates are associated with younger women, certain ethnic groups and high frequency of alcohol consumption. Forty-three percent of women, who had attended at least one follow-up visit, were HPV negative. The incidence tended to decrease by 20% in the first year, 14% and 9% in the second and third years, respectively. The median duration of HPV infection was 8 months. 70% of women were no longer infected one year after the incident and 9% continued to be infected for two years. The longest median duration of infection was established for HPV 16, 18, 61, 73 and AE7. In developed countries, the highest rates of HPV infection have been observed among 15-25-year old women who might reflect transmission during their first sexual intercourse whereas the infection rate Jira Chansaenroj et al

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Human Papillomavirus Infection and Time to Progression and Regression of Cervical Intraepithelial Neoplasia

Abstract: Precursor lesions of the cervix persist longer and progress more quickly in women with oncogenic HPV infections than in women with non-oncogenic infections or without HPV. Testing cervical lesions for oncogenic HPVs may help identify those that are likely to progress rapidly.

Cited by 288 publications

References 23 publications

High viral loads of human papillomavirus predict risk of invasive cervical carcinoma

High viral loads of human papillomavirus predict risk of invasive cervical carcinoma

European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1

High-risk Human Papillomavirus Genotype Detection by Electrochemical DNA Chip Method

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