“…The degree of genomic instability parallels the degree of centrosome abnormalities in cell lines from breast , pancreas , prostate (Pihan et al, 2001), colon (Ghadimi et al, 2000), and cervix tumors (Skyldberg et al, 2001), from short-term culture of mouse mammary tumors (Montagna et al, 2002), and from SV40 ST overexpressing fibroblasts (Gaillard et al, 2001). Centrosome abnormalities were higher in high-grade prostate tumors (Pihan et al, 2001) and high-grade cervical tumors (Skyldberg et al, 2001) than in low-grade tumors. Centrosome amplification and chromosomal instability can be induced by over-expression of the centrosomal protein pericentrin and by over-expression of the centrosome kinase BTAK/STK15, suggesting that alternative mechanisms may lead to centrosome defects and consequent genomic instability (Pihan et al, 2001;Zhou et al, 1998).…”