Human Papillomavirus Infection in Cyclosporin‐Induced Gingival Overgrowth in Renal Allograft Recipients

Abstract

The suppression of T-cell function by cyclosporin therapy can result in an increase of HPV infection, adding to the proliferative activity of cyclosporin in the oral mucosa.

Association of periodontitis and human papillomavirus in oral rinse specimens

“…20 Other researchers, using the Southern blot method with 32P-radiolabeled DNA found HPV in 30% of gingival tissue with gingivitis or periodontitis, which also suggested gingival epithelium was a potential reservoir for HPV; 34 and 92.3% of 13 biopsies of gingival overgrowth lesions in renal allograft recipients were HPV +. 17 …”

Herpesviruses in periodontal diseases

“…In patients with acute myeloid leukemia, HSV may be an important pathogen of oral mucosal ulcerations (214). Viruses other than herpesviruses can also reside in the human periodontium, but their relationship to destructive periodontal diseases remains unclear (18, 30, 65, 116, 140, 143, 144, 176, 199, 250). Hormia et al.…”

Papilloma Development and Long-term Ciclosporin Use in Chronic Ocular Allergy With Associated Keratoconus

“…Ciclosporin was used as a local immunosuppressant in this patient, and it is postulated that this immunosuppressive therapy lead to the reactivation of the virus in this patient. 10 Seibel et al 11 demonstrated the development of similar lesions in dogs treated with ciclosporin. 6 This complex of ciclosporin and cyclophilin inhibits calcineurin, an enzyme which under normal circumstances is responsible for activating the transcription of interleukin-2 and the resulting T-cell clonal expansion.…”