Human papillomavirus infection in esophageal squamous cell carcinoma and esophageal adenocarcinoma: a concise review

Rajendra, Shanmugarajah; Pavey, Darren; McKay, Owen; Merrett, Neil D.; Gautam, Shweta D.

doi:10.1111/nyas.14509

Cited by 19 publications

(23 citation statements)

References 88 publications

(244 reference statements)

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“…The specificity of PCR primer pairs, the sensitivity of the tests, sample storing duration and condition may affect the sample integrity. In particular, archived samples collected for more than 10 years may contain DNA of poor quality as a portion of the DNA may have been degraded [ 27 , 28 ]. In order to provide a conclusive role of HPV in EAC, more studies are required.…”

Section: Association Between Oncoviruses and Oesophageal Cancermentioning

confidence: 99%

Oesophageal carcinoma: The prevalence of DNA tumour viruses and therapy

Luk

Xia

et al. 2022

Tumour Virus Research

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Oesophageal carcinoma ranks the sixth leading cause of cancer death and affected 544,000 - 604,000 people in 2020. Patients often presented with a poor cancer prognosis with a low survival rate of 15–25%. Depending upon the cell type, oesophageal carcinoma is categorised into oesophageal squamous cell carcinoma (ESCC) and oesophageal adenocarcinoma (EAC). ESCC is predominantly reported in developing countries, while EAC is more common in developed countries. Aside from the presence of exogenous co-factors, such as cigarette smoking, alcohol consumption, obesity, gastroesophageal reflux disease (GERD); infection with oncogenic viruses is suspected to be one of the major factors contributing to EC development. Oncogenic viruses, including human papillomavirus (HPV), Epstein Barr virus (EBV), Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV) have been detected in various proportions of EC samples. Nonetheless, their aetiological roles in EC remain debatable. In this review, we garnered previous studies that focus on the association between oncogenic viruses and EC. Among these oncogenic viruses, HPV appears to have a stronger association with EC than the others. In addition, we also discuss the pros and cons of the treatment regimens to treat EC patients, including immunotherapy, chemo- and chemoradiotherapy, and their efficacy.

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Section: Association Between Oncoviruses and Oesophageal Cancermentioning

confidence: 99%

Oesophageal carcinoma: The prevalence of DNA tumour viruses and therapy

Luk

Xia

et al. 2022

Tumour Virus Research

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“…In cervical cancer, p16INK4A is a well-known surrogate marker for human papillomavirus (HPV) infection, which is established as a carcinogen. However, the association between HPV infection and ESCC carcinogenesis remains controversial 42 . In the present study, immunohistochemical expression of p16INK4 was not observed in the non-neoplastic epithelium, whereas expression of p16INK4 was observed in 46–69% of neoplastic epithelium.…”

Section: Discussionmentioning

confidence: 99%

Novel genomic alteration in superficial esophageal squamous cell neoplasms in non-smoker non-drinker females

Onozato

Sasaki

Abe

et al. 2021

Sci Rep

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Alcohol consumption and smoking pose a significant risk for esophageal squamous cell neoplasia (ESCN) development in males; however, ESCN is often diagnosed in non-drinking and non-smoking females. The mechanisms underlying these differences remain elusive, and understanding them can potentially identify novel pathways involved in ESCN development. We performed short-read sequencing to identify somatic variants on a cancer panel targeting 409 genes using DNA extracted from the superficial squamous cell carcinoma (ESCC) tissues and adjacent non-neoplastic epithelium (NE), and immunohistochemical staining of the protein encoded by the target gene. All male patients (n = 117) were drinkers or smokers, whereas 45% of the female patients (n = 33) were not. Somatic variants were compared among three age-matched groups: 13 female ESCC patients with smoking and drinking habits (known-risk group, F-KR), 13 female ESCC patients without these habits (unknown-risk group, F-UR), and 27 males with ESCC and smoking and drinking habits (M-KR). In the NE, the frequencies of CDKN2A variants were significantly higher in F-UR than in F-KR and M-KR. In both ESCC and NE, p14ARF was significantly overexpressed in F-UR than in the other groups. In conclusion, CDKN2A might be important in ESCC development, independent of known risk factors.

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“…Some viral infections are involved in the development of some neoplasms. The human papillomavirus (HPV) may promote a distinct microenvironment in esophageal squamous cell carcinoma [ 38 ]. HPV infection seems related to HSP 90 and 16.2 overexpression [ 39 , 40 ], enabling a microenvironment prone to DNA instability.…”

Section: Literature Reviewmentioning

confidence: 99%

The Role of the Heat-Shock Proteins in Esophagogastric Cancer

Tustumi

Agareno

Galletti

et al. 2022

Cells

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Heat-shock proteins (HSPs) are a family of proteins that have received considerable attention over the last several years. They have been classified into six prominent families: high-molecular-mass HSP, 90, 70, 60, 40, and small heat shock proteins. HSPs participate in protein folding, stability, and maturation of several proteins during stress, such as in heat, oxidative stress, fever, and inflammation. Due to the immunogenic host’s role in the combat against cancer cells and the role of the inflammation in the cancer control or progression, abnormal expression of these proteins has been associated with many types of cancer, including esophagogastric cancer. This study aims to review all the evidence concerning the role of HSPs in the pathogenesis and prognosis of esophagogastric cancer and their potential role in future treatment options. This narrative review gathers scientific evidence concerning HSPs in relation to esophagus and gastric cancer. All esophagogastric cancer subtypes are included. The role of HSPs in carcinogenesis, prognostication, and therapy for esophagogastric cancer are discussed. The main topics covered are premalignant conditions for gastric cancer atrophic gastritis, Barrett esophagus, and some viral infections such as human papillomavirus (HPV) and Epstein–Barr virus (EBV). HSPs represent new perspectives on the development, prognostication, and treatment of esophagogastric cancer.

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Human papillomavirus infection in esophageal squamous cell carcinoma and esophageal adenocarcinoma: a concise review

Cited by 19 publications

References 88 publications

Oesophageal carcinoma: The prevalence of DNA tumour viruses and therapy

Oesophageal carcinoma: The prevalence of DNA tumour viruses and therapy

Novel genomic alteration in superficial esophageal squamous cell neoplasms in non-smoker non-drinker females

The Role of the Heat-Shock Proteins in Esophagogastric Cancer

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