Human papillomavirus infection in patients with laryngeal carcinoma

Çelebi, Özlem Önerci; Şener, Ebru; Hoşal, Şefik; Cengiz, Mustafa; Güllü, İbrahi̇m; Tezel, Gaye Güler

doi:10.1186/s12885-018-4890-8

Cited by 20 publications

(11 citation statements)

References 24 publications

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“…Also, another study by Kreimer et al has shown that the rate of infection with HPV in laryngeal cancer tissue was 24%, which is in agreement with our results, but also showing that a 19% HPV infection rate was seen in normal laryngeal mucosa as well [27]. In accordance with other studies, our results have shown 18.2% HPV-driven laryngeal cancer [26,29], compared to studies that showed a lower association [30,31].…”

Section: Discussionsupporting

confidence: 93%

Prevalence of Human Papillomavirus Associated with Head and Neck Squamous Cell Carcinoma in Jordanian Patients

Khasawneh¹,

Himsawi²,

Abu-Raideh³

et al. 2020

TOMICROJ

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Background: In addition to smoking and alcohol consumption, human papillomavirus (HPV) is a leading etiology for Head and Neck Squamous Cell Carcinoma (HNSCC). However, this causal association is still understudied in Middle Eastern populations. Objective: The aim of this study was to determine the prevalence of HPV-associated infection in the Jordanian HNSCC patients and the associated HPV genotypes. Methods: Formalin-Fixed Paraffin-Embedded (FFPE) squamous cell carcinoma samples of the head and neck were collected from two referral centers in Amman, Jordan to determine the existence of HPV DNA. After DNA extraction HPV infection and genotyping were identified using real-time PCR. Results: HPV DNA was detected in 19 out of 61 (31.1%) HNSCC samples. Despite screening for 28 different genotypes, HPV 16 was the only genotype identified in all examined samples. Most HPV-positive samples were obtained from the oropharynx (41.7%), oral cavity (37%), and larynx (18.2%). No significant association between HPV 16 genotype and age, sex, tobacco use, anatomical location, or tumor grade was noticed. Conclusion: This study reported a high association between HPV 16 genotype and HNSCC in Jordanian patients. These data should facilitate the implementation of appropriate HPV awareness campaigns, and activate selective prophylactic measures against HPV infection.

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Section: Discussionsupporting

confidence: 93%

Prevalence of Human Papillomavirus Associated with Head and Neck Squamous Cell Carcinoma in Jordanian Patients

Khasawneh¹,

Himsawi²,

Abu-Raideh³

et al. 2020

TOMICROJ

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“…Согласно другим литературным данным, ВПЧ является причиной от 0 до 44% случаев рака полости рта, от 0 до 86 -ротоглотки, от 0 до 36%гортани. Столь большой разброс может быть объяснен демографическими особенностями популяции и разными методами как обнаружения, так и экстраполяции [25].…”

Section: вирус эпштейна-баррunclassified

Risk Factors for the Development of Malignant Tumors of the Head and Neck

Belyakova¹

2021

Epidemiology and Vaccinal Prevention

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Relevance. Recently, there has been an increase in the incidence of head and neck cancer throughout. Head and neck cancer is one of the most common forms of cancer, accounting for 5-10% of all cancers in the world. In the structure of cancer it takes 8th place. Aim. Highlight the main risk factors for the development of malignant neoplasms of the head and the etiological role of the human papillomavirus. Conclusions. Currently, it is an increase in prevalence of viral infections is considered to be the main cause of increase in the incidence of squamous cell carcinoma of the head and neck, and this pathology is more common among non-smoking middleaged man with a high socio-economic status, having oral-genital sex with multiple sexual partners, as well as having poor dental status.

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“…Hypopharynx, which show low, or no HPV positivity, is sometimes included with laryngeal region for HPV prevalence studies. Data presented in the figure is derived from different systematic reviews and meta-analyses ( Miller and Johnstone, 2001 ; Syrjanen, 2003 ; Kreimer et al, 2005 ; Sarkola et al, 2008 ; Rautava and Syrjanen, 2011 ; Syrjanen et al, 2017 ; Onerci Celebi et al, 2018 ). [Image originally produced by Macmillan Cancer Support and reused with permission].…”

Section: Hpv In Handn Region and Association With The Cancer Causationmentioning

confidence: 99%

Human Papillomavirus Infection in Head and Neck Squamous Cell Carcinomas: Transcriptional Triggers and Changed Disease Patterns

Aggarwal

Yadav

Thakur

et al. 2020

Front. Cell. Infect. Microbiol.

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Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers. Collectively, HNSCC ranks sixth in incidence rate worldwide. Apart from classical risk factors like tobacco and alcohol, infection of human papillomavirus (HPV) is emerging as a discrete risk factor for HNSCC. HPV-positive HNSCC represent a distinct group of diseases that differ in their clinical presentation. These lesions are well-differentiated, occur at an early age, and have better prognosis. Epidemiological studies have demonstrated a specific increase in the proportions of the HPV-positive HNSCC. HPV-positive and HPV-negative HNSCC lesions display different disease progression and clinical response. For tumorigenic-transformation, HPV essentially requires a permissive cellular environment and host cell factors for induction of viral transcription. As the spectrum of host factors is independent of HPV infection at the time of viral entry, presumably entry of HPV only selects host cells that are permissive to establishment of HPV infection. Growing evidence suggest that HPV plays a more active role in a subset of HNSCC, where they are transcriptionally-active. A variety of factors provide a favorable environment for HPV to become transcriptionally-active. The most notable are the set of transcription factors that have direct binding sites on the viral genome. As HPV does not have its own transcription machinery, it is fully dependent on host transcription factors to complete the life cycle. Here, we review and evaluate the current evidence on level of a subset of host transcription factors that influence viral genome, directly or indirectly, in HNSCC. Since many of these transcription factors can independently promote carcinogenesis, the composition of HPV permissive transcription factors in a tumor can serve as a surrogate marker of a separate molecularly-distinct class of HNSCC lesions including those cases, where HPV could not get a chance to infect but may manifest better prognosis.

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Human papillomavirus infection in patients with laryngeal carcinoma

Cited by 20 publications

References 24 publications

Prevalence of Human Papillomavirus Associated with Head and Neck Squamous Cell Carcinoma in Jordanian Patients

Prevalence of Human Papillomavirus Associated with Head and Neck Squamous Cell Carcinoma in Jordanian Patients

Risk Factors for the Development of Malignant Tumors of the Head and Neck

Human Papillomavirus Infection in Head and Neck Squamous Cell Carcinomas: Transcriptional Triggers and Changed Disease Patterns

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