Human papillomavirus infection in pregnant women

Domža, Gintautas; Gudlevičienė, Živilė; Didžiapetrienė, Janina; Valuckas, Konstantinas Povilas; Kazbarienė, Birutė; Drąsutienė, Gražina Stanislava

doi:10.1007/s00404-010-1787-4

Cited by 18 publications

(23 citation statements)

References 19 publications

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“…Similarly, we have demonstrated that the risk for incident oral HPV infections and their persistence is markedly decreased by a new pregnancy [15,27]. Most previous studies have focused only on differences in HPV prevalence among the pregnancy trimesters [28,29]. A recent study showed that among persistent HPV infections, childbirth proved to be a cofactor for high-grade cervical disease but not pregnancy [30].…”

Section: Discussionmentioning

confidence: 65%

The clearance of oral high-risk human papillomavirus infection is impaired by long-term persistence of cervical human papillomavirus infection

Louvanto

Rautava

Syrjänen

et al. 2014

Clinical Microbiology and Infection

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Persistence of high-risk (HR-) human papillomavirus (HPV) infection of the uterine cervix increases the risk of cervical cancer. Oral HPV infections are among potential covariates of long-term genotype-specific persistent cervical HR-HPV infections. It is not known whether this persistence reflects inability of the host to reject HPV infections in general. A case-control setting was designed to estimate the covariates of long-term persistent cervical HR-HPV infections using multivariate generalized estimating equation (GEE) models. HPV was detected with PCR using GP05+/GP06+-primers and genotyped for 24 HPVs with a Multimetrix-kit. The cases (n=43) included women who had genotype-specific persistent cervical HR-HPV infection for at least 24 months (24M+) and controls were women who tested repeatedly HPV-negative in their cervical samples (n=52). These women represent a sub-cohort of the Finnish Family HPV Study. The cases differed significantly from the HPV-negative controls in several aspects: they were younger, had a longer mean time to incident oral HPV infection (40.7 versus 23.6 months), longer duration of oral HPV persistence (38.4 versus 14.1 months), and longer time to clearance of their oral HPV infection (50.0 versus 28.2 months). In multivariate GEE analysis, the second pregnancy during the follow up was the only independent predictor with significant protective effect against 24M+ persistent cervical HR-HPV infections, OR of 0.15 (95% CI 0.07-0.34). To conclude, long-term persistent cervical HR-HPV infections are associated with a prolonged clearance of oral HR-HPV infections while new pregnancy protects against persistent cervical HR-HPV infections.

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Section: Discussionmentioning

confidence: 65%

The clearance of oral high-risk human papillomavirus infection is impaired by long-term persistence of cervical human papillomavirus infection

Louvanto

Rautava

Syrjänen

et al. 2014

Clinical Microbiology and Infection

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“…However, not all studies have confirmed an increased risk of HPV infection in pregnancy, and yet other reports have suggested that the clearance of HPV infection is not different between pregnant and non‐pregnant patients . As such, the association between HPV infection and pregnancy remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…4 However, not all studies have confirmed an increased risk of HPV infection in pregnancy, 9,18 and yet other reports have suggested that the clearance of HPV infection is not different between pregnant and non-pregnant patients. 10,19 As such, the association between HPV infection and pregnancy remains controversial. We propose that this apparent contradiction in the literature may be due in part to the fact that HPV prevalence rates change throughout gestation, a fact that is not accounted for in these prior publications.…”

Section: Discussionmentioning

confidence: 99%

Genotypic prevalence of human papillomavirus infection during normal pregnancy: A cross‐sectional study

Kim

Park

Norwitz

et al. 2013

J of Obstet and Gynaecol

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“…Domza et al [8] determined the prevalence, serotype and the change of prevalence of HPV during pregnancy by taking cervicovaginal washings from 213 women before pregnancy (baseline) and again in the first and third trimester. At the time of the first sample, 17.8% of women (38/213) were HPV positive, and of these 38, 20 (52.6%) had HR-HPV serotypes.…”

Section: Hpv In Pregnant and Non-pregnant Womenmentioning

confidence: 99%

The potential role of HPV vaccination in the prevention of infectious complications of pregnancy

Bonde

Joergensen

Mogensen

et al. 2014

Expert Review of Vaccines

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There is now incontrovertible evidence that HPV is the cause of almost all cases of genital warts, cervical dysplasia and cervical cancer. Moreover the current review of the recent literature on HPV in relation to pregnancy found strong indications that HPV plays an important role in adverse outcomes of pregnancy. HPV may contribute to infertility and may increase the risk of miscarriage. Recent studies indicate a significant rate of vertical transmission of HPV between mother and child but whether the mode of delivery makes a difference to the risk of transmission remains unknown. HPV infection appears to be correlated with both spontaneous preterm birth and preterm prelabor rupture of the membranes.

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Human papillomavirus infection in pregnant women

Abstract: Our study shows the high prevalence of HPV infection in pregnant women in Lithuania. The majority of pregnant women's HPV infection was cleared during the pregnancy. Only in a few cases a new HPV infection was detected.

Cited by 18 publications

References 19 publications

The clearance of oral high-risk human papillomavirus infection is impaired by long-term persistence of cervical human papillomavirus infection

The clearance of oral high-risk human papillomavirus infection is impaired by long-term persistence of cervical human papillomavirus infection

Genotypic prevalence of human papillomavirus infection during normal pregnancy: A cross‐sectional study

The potential role of HPV vaccination in the prevention of infectious complications of pregnancy

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