Human papillomavirus infection in <scp>B</scp>owen disease: Negative p53 expression, not p16<scp><sup>INK</sup></scp><sup>4a</sup> overexpression, is correlated with human papillomavirus‐associated <scp>B</scp>owen disease

Murao, Kazutoshi; Yoshioka, Rika; Kubo, Yoshiaki

doi:10.1111/1346-8138.12613

Cited by 32 publications

(16 citation statements)

References 52 publications

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“…This role was clearly identified in cervical, anogenital, and some oropharyngeal carcinomas. However, the role of mHPV in NMSC carcinogenesis remains unclear …”

Section: Introductionmentioning

confidence: 99%

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

et al. 2019

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Background: Several studies have reported the oncogenic role of human papillomavirus (HPV) in non-melanoma skin cancer (NMSC) carcinogenesis.Considering that HPV could affect tumor protein 53 (TP53) degradation via E6 oncoprotein, we evaluated the expression of TP53 according to HPV infection and E6 expression. Methods: Biopsy specimens from 79 NMSCs (28 squamous cell carcinomas, 21 keratoacanthomas and 30 basal cell carcinomas) were enrolled. Nested PCR was used to detect mucosal HPV (mHPV) DNA. Genotyping was performed by reverse line hybridization. Expression of TP53 and E6 was evaluated by immunohistochemistry. Results: mHPVs were detected in 34.2% (27/79) of NMSC, with 92.6% (25/27) of high-risk HPV (HR-HPV) types. HPV16-E6-positive expression was observed in all HPV16-positive samples. TP53 high expression was found in 51.4% (37/72) of specimens. In this group, 78.4% were HPV-negative (P = 0.014). TP53 expression was negative in 8/10 of HPV E6-positive specimens.Multivariate analysis showed that TP53 was associated with HPV infection independently of histopathologic type (P = 0.005).Conclusion: This study showed a high prevalence of mHPV in NMSC. Active infections assessed by E6 expression are associated with loss of p53 function, highlighting the involvement of mHPV in NMSC carcinogenesis. K E Y W O R D SHPV16-E6s, mucosal human papillomavirus, non-melanoma skin cancer, TP53, Tunisian

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“…This role was clearly identified in cervical, anogenital, and some oropharyngeal carcinomas. However, the role of mHPV in NMSC carcinogenesis remains unclear …”

Section: Introductionmentioning

confidence: 99%

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

et al. 2019

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“…Previous studies of p16 immunostaining in premalignant and malignant keratinocytic lesions showed discrepant results . Comparison between these different studies is difficult, because different scoring methods were used.…”

Section: Discussionmentioning

confidence: 96%

“…There is evidence that in OTR HPV plays a role in development of keratinocyte neoplasia. However, no significant association between p16 protein expression and the presence of HPV has been found . The mechanism of p16 expression in keratinocytic neoplasia is not completely understood.…”

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confidence: 99%

p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern

et al. 2016

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“… References : Daley et al, Gimeno et al, Patterson et al, Ulbright et al, Brentjens et al, Murao et al …”

Section: Discussionmentioning

confidence: 99%

Distinguishing bowenoid papulosis from Bowen disease in the mouth: A case report

et al. 2019

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Bowenoid papulosis (BPap) is an uncommon skin disorder linked to human papillomavirus (HPV) infection and characterized clinically by the presence of scattered papules or small plaques, multiple and pigmented, that involve the stratified squamous epithelium. Bowen disease (BD) is recognized as the main differential diagnosis of BPap. An 80-year old white woman was referred for the evaluation of multiple, brown verrucous papules measuring 3 to 4 mm in diameter on the right maxillary gingiva. Histopathological analysis revealed disturbed epithelial maturation with papillary stratified squamous epithelium, koilocytic dysplasia, parakeratosis, acanthosis, basal double-layer, loss of cellular polarity, nuclear hyperchromatism and pleomorphism, scattered mitosoid bodies, and a high degree of cytologic atypia. An immunohistochemical investigation for p53 and Ki67 showed staining of the basal and suprabasal layer, while p16 was strongly expressed in the nuclei of epithelial cells and Bcl-2 was positive only in mitosoid bodies and the lymphocytic inflammatory infiltrate. In situ DNA hybridization was negative for HPV. OralBPap is an uncommon lesion in which the diagnostic process includes clinical, histopathological, and molecular correlations due to the similarity to aggressive behavior lesions such as BD.

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Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16^INK^4a overexpression, is correlated with human papillomavirus‐associated Bowen disease

Cited by 32 publications

References 52 publications

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern

Distinguishing bowenoid papulosis from Bowen disease in the mouth: A case report

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Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16INK4a overexpression, is correlated with human papillomavirus‐associated Bowen disease

Cited by 32 publications

References 52 publications

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern

Distinguishing bowenoid papulosis from Bowen disease in the mouth: A case report

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Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16^INK^4a overexpression, is correlated with human papillomavirus‐associated Bowen disease