Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia

Alibegashvili, Tamar; Clifford, Gary M.; Vaccarella, Salvatore; Baidoshvili, Alexi; Gogiashvili, L; Tsagareli, Z; Kureli, Ioseb; Snijders, Peter J.F.; Heideman, Daniëlle A.M.; Kemenade, Folkert J. van; Meijer, Chris J.L.M.; Kordzaia, Dimitri; Franceschi, Silvia

doi:10.1016/j.canep.2010.12.006

Cited by 23 publications

(18 citation statements)

References 26 publications

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“…As seen in most countries, HPV16 is the most common type found in women with or without cancer (34,35). The combined prevalence of HPV16, and HPV18 was highest in the youngest age groups in this country.…”

Section: Discussionmentioning

confidence: 50%

Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala

Gharzouzi

Guerra

et al. 2017

Preprint

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Section: Discussionmentioning

confidence: 50%

Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala

Gharzouzi

Guerra

et al. 2017

Preprint

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“…The IARC has coordinated cervical cancer case series, cervical cancer case-control studies, and population-based HPV prevalence surveys in a large number of countries around the world (Bosch et al, 1995; Muñoz et al, 2003; Franceschi et al, 2003; Clifford et al, 2005; Li et al, 2006; Bardin et al, 2008; Dondog et al, 2008; Keita et al, 2009; Sherpa et al, 2010; Alibegashvili et al, 2011; De Vuyst et al, 2012; Aruhuri et al, 2012; Sideri et al, 2009) and as yet unpublished studies from Fiji, Bhutan, and Senegal. The collection of samples has spanned a period of over 20 years, but predates the introduction of HPV vaccines.…”

Section: Methodsmentioning

confidence: 99%

Human papillomavirus 33 worldwide genetic variation and associated risk of cervical cancer

et al. 2014

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Human papillomavirus (HPV) 33, a member of the HPV16-related alpha-9 species group, is found in approximately 5% of cervical cancers worldwide. The current study aimed to characterize the genetic diversity of HPV33 and to explore the association of HPV33 variants with the risk for cervical cancer. Taking advantage of the International Agency for Research on Cancer biobank, we sequenced the entire E6 and E7 open reading frames of 213 HPV33-positive cervical samples from 30 countries. We identified 28 HPV33 variants that formed 5 phylogenetic groups: the previously identified A1, A2, and B (sub) lineages and the novel A3 and C (sub)lineages. The A1 sublineage was strongly over-represented in cervical cases compared to controls in both Africa and Europe. In conclusion, we provide a classification system for HPV33 variants based on the sequence of E6 and E7 and suggest that the association of HPV33 with cervical cancer may differ by variant (sub)lineage.

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“…The IARC has coordinated cervical cancer case series, cervical cancer case-control studies, and population-based HPV prevalence surveys in a large number of countries around the world (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35); also as-yet-unpublished studies from Fiji and Bhutan). The collection of samples has spanned a period of over 20 years from 1989 until 2012 and predates the introduction of HPV vaccines.…”

Section: Methodsmentioning

confidence: 99%

Human Papillomavirus 45 Genetic Variation and Cervical Cancer Risk Worldwide

Chen¹,

Heideman²,

Boon³

et al. 2014

J Virol

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Human papillomavirus 45 (HPV45) is a member of the HPV18-related alpha-7 species and accounts for approximately 5% of all cervical cancer cases worldwide. This study evaluated the genetic diversity of HPV45 and the association of HPV45 variants with the risk of cervical cancer by sequencing the entire E6 and E7 open reading frames of 300 HPV45-positive cervical samples from 36 countries. A total of 43 HPV45 sequence variants were identified that formed 5 phylogenetic sublineages, A1, A2, A3, B1, and B2, the distribution of which varied by geographical region. Among 192 cases of cervical cancer and 101 controls, the B2 sublineage was significantly overrepresented in cervical cancer, both overall and in Africa and Europe separately. We show that the sequence analysis of E6 and E7 allows the classification of HPV45 variants and that the risk of cervical cancer may differ by HPV45 variant sublineage. IMPORTANCEThis work describes the largest study to date of human papillomavirus 45 (HPV45)-positive cervical samples and provides a comprehensive reference for phylogenetic classification for use in epidemiological studies of the carcinogenicity of HPV45 genetic variants, particularly as our findings suggest that the B2 sublineage of HPV45 is associated with a higher risk of cervical cancer.

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Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia

Cited by 23 publications

References 26 publications

Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala

Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala

Human papillomavirus 33 worldwide genetic variation and associated risk of cervical cancer

Human Papillomavirus 45 Genetic Variation and Cervical Cancer Risk Worldwide

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