Human papillomavirus infection in women with and without cervical cancer in Warsaw, Poland

Bardin, Andrea; Vaccarella, Salvatore; Clifford, Gary M.; Lissowska, Jolanta; Rekosz, M; Bobkiewicz, Piotr; Kupryjańczyk, Jolanta; Krynicki, Ryszard; Jońska-Gmyrek, Joanna; Dańska-Bidzińska, Anna; Snijders, Peter J.F.; Meijer, Chris J.L.M.; Zatoński, Witold; Franceschi, Silvia

doi:10.1016/j.ejca.2007.12.001

Cited by 60 publications

(49 citation statements)

References 17 publications

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“…The IARC has coordinated cervical cancer case series, cervical cancer case-control studies, and population-based HPV prevalence surveys in a large number of countries around the world (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35); also as-yet-unpublished studies from Fiji and Bhutan). The collection of samples has spanned a period of over 20 years from 1989 until 2012 and predates the introduction of HPV vaccines.…”

Section: Methodsmentioning

confidence: 99%

Human Papillomavirus 45 Genetic Variation and Cervical Cancer Risk Worldwide

Chen¹,

Heideman²,

Boon³

et al. 2014

J Virol

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Human papillomavirus 45 (HPV45) is a member of the HPV18-related alpha-7 species and accounts for approximately 5% of all cervical cancer cases worldwide. This study evaluated the genetic diversity of HPV45 and the association of HPV45 variants with the risk of cervical cancer by sequencing the entire E6 and E7 open reading frames of 300 HPV45-positive cervical samples from 36 countries. A total of 43 HPV45 sequence variants were identified that formed 5 phylogenetic sublineages, A1, A2, A3, B1, and B2, the distribution of which varied by geographical region. Among 192 cases of cervical cancer and 101 controls, the B2 sublineage was significantly overrepresented in cervical cancer, both overall and in Africa and Europe separately. We show that the sequence analysis of E6 and E7 allows the classification of HPV45 variants and that the risk of cervical cancer may differ by HPV45 variant sublineage. IMPORTANCEThis work describes the largest study to date of human papillomavirus 45 (HPV45)-positive cervical samples and provides a comprehensive reference for phylogenetic classification for use in epidemiological studies of the carcinogenicity of HPV45 genetic variants, particularly as our findings suggest that the B2 sublineage of HPV45 is associated with a higher risk of cervical cancer.

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Section: Methodsmentioning

confidence: 99%

Human Papillomavirus 45 Genetic Variation and Cervical Cancer Risk Worldwide

Chen¹,

Heideman²,

Boon³

et al. 2014

J Virol

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“…21 Major study strengths include a large population-based sample and the use of a standardized and well-validated HPV test allowing comparisons with similar studies around the world. [3][4][5][6][7][8][9][10] The main limitation was the fact that vaginal examination was acceptable only to married women, as in similar surveys in Asia. 6,10,22 This meant that, in a setting where the average age of marriage was recently estimated at 29.3 years, 23 few married women younger than 25 years participated in the study.…”

Section: Short Reportmentioning

confidence: 99%

Human papillomavirus infection in a population‐based sample of women in Algiers, Algeria

Hammouda

Clifford

Pallardy

et al. 2011

Intl Journal of Cancer

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No data exist on the population prevalence of, nor risk factors for, human papillomavirus (HPV) infection in the predominantly Muslim countries of Northern Africa. Cervical specimens were obtained from 759 married women aged 15-65 years from the general population of Algiers, Algeria. Liquid-based cytology and HPV DNA detection, using a GP51/61-based polymerase chain reaction assay that detects 44 HPV types, were performed according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV prevalence in the general population was 6.3% (4.0% of highrisk types), with no significant variation by age. The prevalence of cervical abnormalities was 3.6%. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's extramarital sexual relationships. HPV16/18 accounted for only 15% of HPV-positive women in the general population, compared with 77% of invasive cervical cancer diagnosed in the same city. In conclusion, we report that HPV infection among married women in Algeria is much lower than in sub-Saharan Africa and also lower than in the majority of high-resource countries.

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“…The surveys were carried out in the following areas: Hanoi and Ho Chi Minh City, Vietnam (18); Lampang and Songkla, Thailand (19); Korea (20); Shanxi (21), Shenzhen (22), and Shenyang (23), China; Mongolia (24); Argentina (25); Chile (26); Colombia (27); Nigeria (28); Spain (29); and Poland (30). A survey from Dindigul Distreet, India (31) was not included because information on sexual behavior was inadequate.…”

Section: Contributing Studies and Data Collectionmentioning

confidence: 99%

Concurrent Infection with Multiple Human Papillomavirus Types: Pooled Analysis of the IARC HPV Prevalence Surveys

Vaccarella

Franceschi²,

Snijders³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

107

128

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To understand viral interactions and the cross-reactivity of natural or vaccine-induced responses, we investigated whether multiple human papillomavirus (HPV) infections, particularly certain combinations of types, have the tendency to cluster together. Cervical cell samples were collected from women in the framework of the IARC HPV Prevalence Surveys. Women with a cytology diagnosis of high-grade squamous intraepithelial lesion or worse were excluded, leaving 13,961 women for this analysis. HPV DNA was assessed using a general GP5+/6+ primer-mediated PCR. HPV genotyping was done using enzyme immunoassay or reverse line blot analysis. Logistic regression with type-specific HPV positivity as an outcome was used, adjusted for age, study area, and lifetime number of sexual partners. Woman-level random effects were added to represent unobservable risk factors common to all HPV types. The observed-to-expected ratio was 1.20 (95% credible interval, 1.14-1.26) for infection with two HPV types and 1.02 (95% credible interval, 0.91-1.12) for three for more types, with the best possible adjustment. Among combinations of specific HPV types, the tendency to cluster increased with the genetic similarity of the L1 region. High observed-to-expected ratios were found for closely homologous types, including HPV33/58, 18/45, 33/35, and 31/35. The excess of multiple infections, however, was clearly evident only when enzyme immunoassay, and not reverse line blot, was used as the genotyping method. The different results by genotyping method suggest that the apparent clustering of HPV infections was an artifact of the measurement process. Further investigation is required to evaluate other widely used HPV detection methods.

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Human papillomavirus infection in women with and without cervical cancer in Warsaw, Poland

Cited by 60 publications

References 17 publications

Human Papillomavirus 45 Genetic Variation and Cervical Cancer Risk Worldwide

Human Papillomavirus 45 Genetic Variation and Cervical Cancer Risk Worldwide

Human papillomavirus infection in a population‐based sample of women in Algiers, Algeria

Concurrent Infection with Multiple Human Papillomavirus Types: Pooled Analysis of the IARC HPV Prevalence Surveys

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