Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study

Anantharaman, Devasena; Gheit, Tarik; Waterboer, Tim; Abedi-Ardekani, Behnoush; Carreira, Christine; McKay‐Chopin, Sandrine; Gaborieau, Valérie; Marron, Manuela; Λάγιου, Παγώνα; Ahrens, Wolfgang; Holcátová, Ivana; Merletti, Franco; Kjærheim, Kristina; Talamini, Renato; Simonato, Lorenzo; Castellsagué, Xavier; Biggs, Anne Marie; Thakker, Nalin; Znaor, Ariana; Thomson, Peter; Canova, Cristina; Conway, David I.; Healy, Claire M.; Tommasino, Massimo; Pawlita, Michael; Brennan, Paul

doi:10.1093/jnci/djt053

Cited by 122 publications

(145 citation statements)

References 42 publications

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“…Presence of HPV16 E6 antibodies in particular, are thought to be cancer-specific markers owing to their rarity among controls (<1% seropositivity in nearly 6,500 controls based on studies of head and neck cancer; refs. [29][30][31][32]. Conversely, HPV16 E6 seems to be a specific marker for HPV16-positive oropharyngeal cancer (19).…”

Section: Discussionmentioning

confidence: 99%

No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer

Anantharaman¹,

Gheit²,

Waterboer

et al. 2014

Cancer Research

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Human papillomavirus (HPV) infections have been implicated in lung carcinogenesis, but causal associations remain uncertain. We evaluated a potential causal role for HPV infections in lung cancer through an analysis involving serology, tumor DNA, RNA, and p16 protein expression. Association between type-specific HPV antibodies and risk of lung cancer was examined among 3,083 cases and 4,328 controls in two case-control studies (retrospective) and one nested case-control study (prospective design). Three hundred and thirty-four available tumors were subjected to pathologic evaluation and subsequent HPV genotyping following stringent conditions to detect all high-risk and two low-risk HPV types. All HPV DNA-positive tumors were further tested for the expression of p16 protein and type-specific HPV mRNA. On the basis of the consistency of the results, although HPV11 and HPV31 E6 antibodies were associated with lung cancer risk in the retrospective study, no association was observed in the prospective design. Presence of type-specific antibodies correlated poorly with the presence of the corresponding HPV DNA in the tumor. Although nearly 10% of the lung tumors were positive for any HPV DNA (7% for HPV16 DNA), none expressed the viral oncogenes. No association was observed between HPV antibodies or DNA and lung cancer survival. In conclusion, we found no supportive evidence for the hypothesized causal association between HPV infections and lung cancer. Cancer Res; 74(13); 3525-34. Ó2014 AACR.

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Section: Discussionmentioning

confidence: 99%

No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer

Anantharaman¹,

Gheit²,

Waterboer

et al. 2014

Cancer Research

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“…In addition, the incidence of oral cancer is further increased due to the high usage of chewable/smokeless tobacco and betel quid in India (de Camargo Cancela et al, 2010;IARC, 2012;Anantharaman et al, 2013;Krishna et al, 2013). Data from the National Cancer Registry in India shows a gender based difference in oral cancer incidence with a men:women ratio of 2:1 which is suggestive of lifestyle and behavioral differences among genders (Sankaranarayanan et al, 2005;Thorat et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Anti-Cancer Effects of Imperata cylindrica Leaf Extract on Human Oral Squamous Carcinoma cell line SCC-9 in Vitro

Keshava¹,

Muniyappa²,

Gope³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Imperata cylindrica, a tall tufted grass which has multiple pharmacological applications is one of the key ingredients in various traditional medicinal formula used in India. Previous reports have shown that I. cylindrica plant extract inhibited cell proliferation and induced apoptosis in various cancer cell lines. To our knowledge, no studies have been published on the effect of I. cylindrica leaf extract on human oral cancers. The present study was undertaken in order to evaluate the anticancer properties of the leaf extract of I. cylindrica using an oral squamous cell carcinoma cell line SCC-9 as an in vitro model system. A methanol extract from dried leaves of I. cylindrica (ICL) was prepared by standard procedures. Effects of the ICL extract on the morphology of SCC-9 cells was visualized by microscopy. Cytotoxicity was determined by MTT assay. Effects of the ICL extract on colony forming ability of SCC-9 cells was evaluated using clonogenic assay. Cell cycle analysis was performed by flow cytometry and induction of apoptosis was determined by DNA fragmentation assay. The ICL extract treatment caused cytotoxicity and induced cell death in vitro in SCC-9 cells in a dose-dependent manner. This treatment also significantly reduced the clonogenic potential and inhibited cell proliferation by arresting the cell cycle in the G2/M phase. Furthermore, DNA fragmentation assays showed that the observed cell death was caused by apoptosis. This is the first report showing the anticancer activity of the methanol extracts from the leaves of I. cylindrica in human oral cancer cell line. Our data indicates that ICL extract could be considered as one of the lead compounds for the formulation of anticancer therapeutic agents to treat/manage human oral cancers. The natural abundance of I. cylindrica and its wide geographic distribution could render it one of the primary resource materials for preparation of anticancer therapeutic agents.

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“…The large variation in worldwide incidence and mortality from cancers of UADT are mainly attributed to variations in exposure to the major environmental and behavioural risk factors as illustrated in Table 1 ( Brunner et al, 2006) and are namely: tobacco, alcohol, inadequate intake of fruits and vegetables, and infection with human papilloma virus in high cancer incidence areas like India (Dal Maso et al, 2002;Boeing et al, 2006;Pelucchi et al, 2006;Polesel et al, 2008;Ansary-Moghaddam et al, 2009;Gupta et al, 2012;Anantharaman et al, 2013). Further, some epidemiological studies show that employment in industries with occupational exposures to wood dust, asbestos, acid mists or solvents and manufacturing of textiles and leather are associated with an increased risk of UADT cancer (Maier et al, 1997;Jayaprakash et al, 2008;Schmeisser et al, 2010 , 2012).…”

Section: Risk Factors For Upper Aero-digestive Tract Cancermentioning

confidence: 99%

“…Conversely, HPV18 appears to be rare in oropharyngeal cancers (Gillison et al, 2008;Anantharaman et al, 2013). The relationship between HPV infection and laryngeal cancer is of particular interest, given that recurrent respiratory papillomatosis is clearly caused by benign proliferative growths induced by HPV 6 or 11 infection of the laryngeal epithelium (Herrero, 2003).…”

Section: 5983 Global Emerging and Established Life-style Risk Factormentioning

confidence: 99%

Emerging and Established Global Life-Style Risk Factors for Cancer of the Upper Aero-Digestive Tract

Gupta¹,

Johnson²

2014

Asian Pacific Journal of Cancer Prevention

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Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study

Cited by 122 publications

References 42 publications

No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer

No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer

Anti-Cancer Effects of Imperata cylindrica Leaf Extract on Human Oral Squamous Carcinoma cell line SCC-9 in Vitro

Emerging and Established Global Life-Style Risk Factors for Cancer of the Upper Aero-Digestive Tract

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