Human Papillomavirus-Related Cancers Among People Living With AIDS in Puerto Rico

Ortiz, Ana P.; Pérez-Irizarry, Javier; Soto-Salgado, Marievelisse; Suárez, Erick; Pérez, Naydi; Cruz, Maritza; Palefsky, Joel M.; Tortolero‐Luna, Guillermo; Miranda, S. Velazquez; Colón‐López, Vivian

doi:10.5888/pcd11.130361

Cited by 21 publications

(20 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With the increase in the survival of HIV+ women due to HAART, there is an increased opportunity for the progression of oncogenic viral infections into malignancies, particularly in HPV-associated oral, genital, and anal cancers (Adler, 2010;Piketty et al, 2012;Ortiz , 2014). Currently, the HIV/AIDS pandemic is predominantly impacting the poorest and the youngest in resource-limited settings.…”

Section: Introductionmentioning

confidence: 99%

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

Freitas

Suehiro²,

Consolaro³

et al. 2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Human papillomavirus is a virus that is distributed worldwide, and persistent infection with high-risk genotypes (HR-HPV) is considered the most important factor for the development of squamous cell cervical carcinoma (SCC). However, by itself, it is not sufficient, and other factors may contribute to the onset and progression of lesions. For example, infection with other sexually transmitted diseases such as human immunodeficiency virus (HIV) may be a factor. Previous studies have shown the relationship between HPV infection and SCC development among HIV-infected women in many regions of the world, with great emphasis on low-and middleincome countries (LMICs). Brazil is considered a LMIC and has great disparities across different regions. The purpose of this review was to highlight the current knowledge about HPV infection and cervical abnormalities in HIV+ women in Brazil because this country is an ideal setting to evaluate HIV impact on SCC development and serves as model of LMICs and low-resource settings.

show abstract

Section: Introductionmentioning

confidence: 99%

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

Freitas

Suehiro²,

Consolaro³

et al. 2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…One study in Italy showed an increased risk of tonsil cancer (SIR = 10.9, 95% CI: 1.2–39.4) in HIV‐infected men (Franzetti et al , ). Another study from Puerto Rico found an increased risk of oral‐pharyngeal cancer in HIV‐infected women (SIR = 10.9, 95% CI: 1.26–37.6) (Ortiz et al , ). Other studies have reported significant albeit lower risks than these two studies – ranging from an SIR of 1.6 (95% CI: 1.2–2.1) in the USA (Chaturvedi et al , ) to 1.9 (95% CI: 1.8–2.1) in Northern Italy (Calabresi et al , ).…”

Section: Question 2: Are Hpv‐associated Oral Lesions Including Oral‐pmentioning

confidence: 99%

Viral infections associated with oral cancers and diseases in the context of HIV: a workshop report

et al. 2016

View full text Add to dashboard Cite

Human herpesviruses (HHVs) and Human papillomaviruses (HPV) are common in the general population and, in immunocompetent people, are mostly carried asymptomatically. However, once an individual becomes immunocompromised by age, illness, or HIV infection these dormant viruses can manifest themselves and produce disease. In HIV-positive patients there is an increased risk of disease caused by HHVs and HPV infections and cancers caused by the oncoviruses EBV, HHV-8, and HPV. This workshop examined four questions regarding the viruses associated with oral cancers disease in the HIV-positive and -negative populations, the immune response, and biomarkers useful for accurate diagnostics of these infections and their sequalae. Each presenter identified a number of key areas where further research is required.

show abstract

“…Moreover, in HIV+ women, CC tends to respond poorly to recommended therapies, becomes more aggressive, and may have a worse prognosis [6]. With the increase in survival of HIV+ women due to HAART, progression of oncogenic viral infection into malignancy may result in an increased incidence of HPVassociated oropharyngeal, genital, and anal cancers [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil

Suehiro

Damke

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Despite the demonstrated role of human Papillomavirus (HPV) in the etiology of cervical cancer and the strong evidence suggesting the importance of HPV in the development of oropharyngeal cancer, several aspects concerning the interrelationship between HPV infection in both body sites remain unknown, specifically in human immunodeficiency virus (HIV)-positive (HIV+) female patients. We aimed to assess the prevalence, distribution, and concordance of cervical and oral HPV in HIV+ women and matched HIV-negative (HIV-) controls in Brazil. Material and methods: Cervical and endocervical samples for cytological screening and HPV detection and oral samples were collected from 115 HIV+ women using highly active antiretroviral therapy (HAART) and 139 HIV-matched controls (HIV-) in Maringá City, Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding HIV infection were obtained from the patients’ medical records. HPV detection and typing were performed using the Kit Multiplex XGEN Multi HPV Chip HS12. Results: HIV infection was well controlled in this cohort, but women who exhibited detectable HIV load were significantly associated with HPV-positive status in overall (P = 0.03) and in cervical mucosa (P = 0.01). HIV+ women had significantly more abnormal cytological findings (P = 0.04) than HIV- women. Of the 115 HIV+ women, 48.7% were positive for cervical and/or oral HPV DNA; of the 139 HIV- women, 41% were positive for cervical and/or oral HPV (P = 0.25). Both HIV+ and HIV- women had a statistically higher prevalence of cervical HPV infection than oral infection. The concurrent HPV infection in two anatomical sites was similar in HIV+ and HIV- women, however HPV type concordance was not observed. HPV type distribution was different between the anatomical sites in both groups, and HIV+ women presented less common types, mainly in oral mucosa. Conclusion: Our data support the importance of HPV infection in HIV+ women, even when the HIV infection is well controlled. Prospective studies are required to better understand the natural history of HPV infection in both anatomical sites, specifically in HIV+ women.

show abstract

Human Papillomavirus-Related Cancers Among People Living With AIDS in Puerto Rico

Cited by 21 publications

References 9 publications

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

Viral infections associated with oral cancers and diseases in the context of HIV: a workshop report

Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil

Contact Info

Product

Resources

About