Human Papillomavirus Requires COPI Coat Complex for a Successful Infection.
Edrees Khan Rahmatzada,
Om Basukala,
Lawrence Banks
Abstract:Human papillomavirus (HPV) uses the cellular trafficking machinery to reach the cell nucleus and initiate a successful infection. The HPV capsid consists of two proteins: L1 (the major capsid protein) and L2 (minor capsid protein), and L2 is known to be responsible for trafficking the viral genome to the nucleus. From previous studies, we know that many cellular proteins interact with L2 and are involved in the trafficking process at different stages of the infectious entry process. To further investigate how … Show more
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