Human papillomavirus status and prognosis of oropharyngeal high-grade neuroendocrine carcinoma

Sousa, Luana G. de; Neto, Felippe Lazar; Lago, Eduardo A. Dal; Sikora, Andrew G.; Hanna, Ehab Y.; Moreno, Amy C.; Phan, Jack; Glisson, Bonnie S.; Bell, Diana; Ferrarotto, Renata

doi:10.1016/j.oraloncology.2023.106311

Cited by 1 publication

(1 citation statement)

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“…435 HPV infection categorizes tumors into two distinct groups with varying prognoses and therapeutic implications. 436 Generally, HPV + OSCC patients have a better treatment response, a higher two-year overall survival rate, a reduced disease progression risk and an improved prognosis, and lower death and recurrence rate than HPVpatients. 437 p16 is one of the most investigated prognostic biomarkers of OSCC.…”

Section: Therapeutic Interventions For Opmdsmentioning

confidence: 98%

Oral squamous cell carcinomas: state of the field and emerging directions

Tan,

Wang,

et al. 2023

Int J Oral Sci

151

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Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral cavity. It accounts for approximately 90% of oral malignancies and impairs appearance, pronunciation, swallowing, and flavor perception. In 2020, 377,713 OSCC cases were reported globally. According to the Global Cancer Observatory (GCO), the incidence of OSCC will rise by approximately 40% by 2040, accompanied by a growth in mortality. Persistent exposure to various risk factors, including tobacco, alcohol, betel quid (BQ), and human papillomavirus (HPV), will lead to the development of oral potentially malignant disorders (OPMDs), which are oral mucosal lesions with an increased risk of developing into OSCC. Complex and multifactorial, the oncogenesis process involves genetic alteration, epigenetic modification, and a dysregulated tumor microenvironment. Although various therapeutic interventions, such as chemotherapy, radiation, immunotherapy, and nanomedicine, have been proposed to prevent or treat OSCC and OPMDs, understanding the mechanism of malignancies will facilitate the identification of therapeutic and prognostic factors, thereby improving the efficacy of treatment for OSCC patients. This review summarizes the mechanisms involved in OSCC. Moreover, the current therapeutic interventions and prognostic methods for OSCC and OPMDs are discussed to facilitate comprehension and provide several prospective outlooks for the fields.

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Section: Therapeutic Interventions For Opmdsmentioning

confidence: 98%