Human papillomavirus testing as a cytology gold standard: comparing Surinam with the Netherlands

Wachtel, Mitchell S.; Boon, Mathilde E.; Korporaal, Hans; Kok, Lambrecht P.

doi:10.1038/modpathol.3800242

Cited by 7 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Koilocytosis is considered to be virally induced and has been correlated with HPV (27)(28)(29) . The fact that koilocytosis occurred over ten times more frequently in the SuS suggests a higher prevalence of HPV in this population, which is supported by a recent study (18) . It could furthermore be caused by higher viral load or different HPV type variants, as a result of the previously proposed differences in exposure between the high-risk and the low-risk areas studied.…”

Section: Discussionsupporting

confidence: 83%

“…We found that the age‐adjusted ORs for the SuS of developing mild (P4) and moderate to severe dysplasia/neoplasia (P5–9) are higher and increase with (pre)neoplasia grade compared to the SuN (Table 2). One of the possible causes could be that HPV infection, which precedes cervical dysplasia (13,14) , is more common in high‐risk areas for cervical cancer (3,15–17) , including Suriname (18) . This could be associated with the sexual lifestyle encouraged by the Surinamese culture, as was established in several populations (8,14,19) .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased prevalence of dysplasia in high-risk population immigrants in a low-risk area for cervical cancer

Vermeulen¹,

Boon²,

Grunberg³

et al. 2007

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

Incidence rates of cervical cancer and its precursors vary considerably, with the highest rates found in developing countries. Differences are influenced by endogenous and exogenous factors. Comparing cytologic abnormality incidence rates from a high-risk population in the original high-risk area, with those of women from this high-risk population who have immigrated to a low-risk area could give insight in the significance of endogenous versus environmental factors. Smears collected from Surinamese women attending the Surinamese screening program and smears collected from immigrant Surinamese women attending the Dutch screening program were cytologically analyzed using the Dutch microscopical coding system KOPAC. Statistical analysis was performed by using logistic regression to calculate (age-adjusted) odds ratios (ORs). The age-adjusted ORs of having dysplasia were higher for Surinamese women living in Suriname versus Surinamese immigrant women and increased with increasing P-scores: 0.77 (0.31-1.91) for borderline changes, 1.62 (0.58-4.57) for mild dysplasia, and 3.20 (1.55-6.60) for moderate to severe dysplasia/neoplasia. We conclude that fewer cases with dysplasia are present in a high-risk population that has immigrated to a low-risk area for cervical cancer than in the high-risk population continuously living in a high-risk area. This finding emphasizes the importance of environmental factors.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Decreased prevalence of dysplasia in high-risk population immigrants in a low-risk area for cervical cancer

Vermeulen¹,

Boon²,

Grunberg³

et al. 2007

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

show abstract

“…The scraped off cells were suspended in 1000 μl of TRIS‐HCL buffer (10 mM [pH 8.3]), and centrifuged for 5 minutes at 13,000 revolutions per minute. This cell pellet was used for PCR as described by Van den Brule et al7 In this procedure, only the HR‐HPV RNA probe mix (B) was used, which detected 11 types of HPV (HPV‐16, HPV‐18, HPV‐31, HPV‐33, HPV‐35, HPV‐39, HPV‐45, HPV‐51, HPV‐52, HPV‐56, and HPV‐58) 8,9…”

Section: Methodsmentioning

confidence: 99%

Alternating high-risk human papillomavirus infection

Rijkaart

Bontekoe²,

Korporaal

et al. 2006

Cancer

Self Cite

View full text Add to dashboard Cite

BACKGROUND. Nearly every Dutch woman will be exposed to genital human papillomavirus (HPV) at least once during her lifetime, and most likely several times. In the current study, the authors investigated the prevalence of high‐risk–HPV (HR‐HPV) infection and the likelihood of progression to cervical intraepithelial neoplasia (CIN). METHODS. In this study, the course of HR‐HPV infection in 703 women was observed. From a database of 720,016 negative cytology smears, the authors selected 703 women based on the availability of at least 2 HR‐HPV polymerase chain reaction tests. The authors database stores not only the HPV data but also all other cytologic and histologic data, allowing the detection of women who progressed from negative cytology to CIN within a period of 10 years. RESULTS. Of the 703 selected women, 159 were found to have alternating HR‐HPV infection (change from a negative HR‐HPV test to a positive test or vice versa), 40 had a persistently positive HR‐HPV test, and 504 women had a persistently negative HR‐HPV test. The percentage of alternating HPV infection declined over time from 37% to 7%. Of the women age older than 40 years, 17% had an alternating HR‐HPV infection, 2 of whom developed CIN. These findings led the authors to conclude that all the women in the current study with an increased risk of developing type 2 or 3 CIN were identified using 2 HPV tests. Women age older than 40 years still have a significant risk of acquiring a HR‐HPV. CONCLUSIONS. In light of the current study findings, the authors believe it is worth considering the inclusion of women age 40 years and older who have negative cytology for HPV testing as part of the Dutch national screening program. Cancer (Cancer Cytopathol) 2006. © 2006 American Cancer Society.

show abstract

“…The prevalence of carcinogenic HPV infection among Surinamese women with normal cytological findings was estimated at 80% in one small study (n=100) 7. HPV positivity was 35.4% in the Caribbean, 15.3% in South America and 11.7% globally in a recent meta-analysis among 1 million women with normal cytological findings 8.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional study of genital carcinogenic HPV infections in Paramaribo, Suriname: prevalence and determinants in an ethnically diverse population of women in a pre-vaccination era

Geraets

Grunberg²,

Helm

et al. 2014

Sex Transm Infect

View full text Add to dashboard Cite

show abstract

Human papillomavirus testing as a cytology gold standard: comparing Surinam with the Netherlands

Cited by 7 publications

References 20 publications

Decreased prevalence of dysplasia in high-risk population immigrants in a low-risk area for cervical cancer

Decreased prevalence of dysplasia in high-risk population immigrants in a low-risk area for cervical cancer

Alternating high-risk human papillomavirus infection

Cross-sectional study of genital carcinogenic HPV infections in Paramaribo, Suriname: prevalence and determinants in an ethnically diverse population of women in a pre-vaccination era

Contact Info

Product

Resources

About