2011
DOI: 10.1038/onc.2010.613
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Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway

Abstract: Deregulation of microRNA (miRNA or miR) expression in human cervical cancer is associated frequently with human papillomavirus (HPV) integration. miR-23b is often downregulated in HPV-associated cervical cancer. Interestingly, urokinase-type plasminogen activator (uPA), the miR-23b target, is detected in cervical cancer, but not in normal cervical tissues. Thus, the importance of miR-23b and uPA in HPV-associated cervical cancer development is investigated. In this study, the high-risk subtype HPV-16 E6 oncopr… Show more

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Cited by 131 publications
(107 citation statements)
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“…Viral oncoprotein E6 or E7 can induce alteration of cellular miRNA expression in different ways during the development and progression of cervical cancer. HPV 16 infection reduced miR-218 expression, resulting in increased expression of LAMB3 (which encodes laminin-5 ␤3), 36 and HPV 16 E6 induced a reduction of miR-34a 14,37 and miR23b, 38 due to the degradation of p53 in cervical cancer cell lines. To determine whether the reduction of miR-375 expression is regulated by HR-HPV oncoproteins, we examined the expression of miR-375 in normal cervical tissues with or without HR-HPV infection.…”
Section: Hr-hpv16 E6/e7 Does Not Directly Regulate Mir-375 Expressionmentioning
confidence: 99%
“…Viral oncoprotein E6 or E7 can induce alteration of cellular miRNA expression in different ways during the development and progression of cervical cancer. HPV 16 infection reduced miR-218 expression, resulting in increased expression of LAMB3 (which encodes laminin-5 ␤3), 36 and HPV 16 E6 induced a reduction of miR-34a 14,37 and miR23b, 38 due to the degradation of p53 in cervical cancer cell lines. To determine whether the reduction of miR-375 expression is regulated by HR-HPV oncoproteins, we examined the expression of miR-375 in normal cervical tissues with or without HR-HPV infection.…”
Section: Hr-hpv16 E6/e7 Does Not Directly Regulate Mir-375 Expressionmentioning
confidence: 99%
“…uPA is the target gene for miR-23b as the miR repressed uPA expression and interacted with the 3′-untranslated region of uPA mRNA. From the above, miR-23b/uPA are confirmed to be involved in HPV-16 E6-associated cervical cancer development ( Au Yeung et al, 2011).…”
Section: Hsa-mir-23bmentioning
confidence: 86%
“…The HPV-16 E6 was also found to decrease expression of miR-23b in SiHa and CaSki cells by repressing the promoter and increased expression of its cellular target, the urokinase-type plasminogen activator (uPA), a known inductor of cell migration in cervical cancer cells. The link between HPV-16 E6 and miR-23b transcription was associated to the presence of a p53 binding site within the miR-23b promoter, suggesting a cell migration modulatory role for E6 (Au Yeung et al, 2011).…”
Section: Micrornas (Mirnas) In Cervical Cancermentioning
confidence: 98%