Human papillomavirus types detected in skin warts and cancer differ in their transforming properties but commonly counteract UVB induced protective responses in human keratinocytes

Shterzer, Naama; Heyman, Dariya; Shapiro, Beny; Yaniv, A.; Jackman, Anna; Serour, Francis; Chaouat, Malka; Gonen, Pinhas; Tommasino, Massimo; Sherman, Levana

doi:10.1016/j.virol.2014.09.015

Cited by 10 publications

(8 citation statements)

References 56 publications

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“…Furthermore, as with α-HPV, the E6 protein of some β-HPVs induces BAK degradation, thus preventing the release of pro-apoptotic mitochondrial factors 103 . The interaction of E6 with E6-AP is required not only for BAK degradation but also for hTERT (human telomerase reverse transcriptase) induction 104 , 105 .…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and biology of cutaneous human papillomavirus

Nunes¹,

Talpe-Nunes²,

Sichero³

2018

Clinics

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Cutaneous human papillomaviruses (HPVs) include β- and γ-HPVs, in addition to a small fraction of α-HPVs. β-HPVs were first isolated from patients with the rare genetic disorder Epidermodysplasia verruciformis, and they are associated with the development of nonmelanoma skin cancer at sun-exposed skin sites in these individuals. Organ transplant recipients also have greater susceptibility to β-HPV infection of the skin and an increased risk of developing nonmelanoma skin cancer. In both immunosuppressed and immunocompromised individuals, cutaneous HPVs are ubiquitously disseminated throughout healthy skin and may be an intrinsic part of the commensal flora. Functional analysis of E6 and E7 proteins of specific cutaneous HPVs has provided a mechanistic comprehension of how these viruses may induce carcinogenesis. Nevertheless, additional research is crucial to better understand the pathological implications of the broad distribution of these HPVs.

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Section: Introductionmentioning

confidence: 99%

Epidemiology and biology of cutaneous human papillomavirus

Nunes¹,

Talpe-Nunes²,

Sichero³

2018

Clinics

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“…Alternatively, the E6 protein from β-1 HPVs 5 and 8, and β-2 HPV-38 also affect DNA repair by inactivating both ATM and ATR activities [97]. Furthermore, as for HR α-HPVs, the E6 protein of some β-HPVs induces BAK degradation, consequently preventing the relief of pro-apoptotic factors [96, 100, 101]. …”

Section: Biology Of Beta Hpvmentioning

confidence: 99%

Beta Human Papillomavirus and Associated Diseases

et al. 2019

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The cutaneous human papillomavirus (HPV), mostly from β- and γ-HPV genus, is ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of β-HPVs and cutaneous squamous cell carcinoma (cSCC) development was initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis. Likewise, immunosuppressed organ transplant recipients have an increased susceptibility to β-HPV infections in the skin as well as to cSCC development. Although ultraviolet radiation (UVR) is the main risk factor of cSCC, experimental data points toward β-HPVs as co-carcinogens, which appear to be required solely at early stages of skin carcinogenesis by facilitating the accumulation of UVR-induced DNA mutations. Several epidemiological studies relying on different biomarkers of β-HPV infections have also been conducted in immunocompetent individuals to access their association with cSCC development. Additionally, in vivo and in vitro studies are presenting cumulative evidence that E6 and E7 proteins from specific β-HPVs exhibit transforming activities and may collaborate with different environmental factors in promoting carcinogenesis. Nevertheless, further research is crucial to better understand the pathological implications of the broad distribution of these HPVs.

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“…1 Meanwhile, other factors including human papillomavirus infection have more recently been implicated in certain cases, e.g., in immunosuppressed patients. 3 The role of a number of genes including TP53, HRAS, EGFR, CDKN2A, and others has also been investigated. 4 Cutaneous squamous cell carcinoma can potentially be treated fully with minimal morbidity when detected at an early stage; however, certain subtypes of cSCC have been shown to confer a poorer prognosis for patients.…”

Section: Introductionmentioning

confidence: 99%

High-risk Cutaneous Squamous Cell Carcinoma

Fitzgerald¹,

O’Neill²

2017

International Journal of Head and Neck Surgery

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Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer worldwide. Cutaneous squamous cell carcinoma can potentially be treated fully with minimal morbidity when detected early; however, certain subtypes of cSCC have been shown to confer a poorer prognosis for patients. In these high-risk tumors, increased incidence of recurrence, as well as metastasis to local lymph nodes and distant sites, is seen as a result of certain patient characteristics and pathological features. While guidelines regarding the management of high-risk cSCC have been produced, no clear consensus management or prognostic algorithms exist. In this review, we discuss current definitions of high-risk cSCC, recommendations regarding the management of cSCC, and current guidelines.

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Human papillomavirus types detected in skin warts and cancer differ in their transforming properties but commonly counteract UVB induced protective responses in human keratinocytes

Cited by 10 publications

References 56 publications

Epidemiology and biology of cutaneous human papillomavirus

Epidemiology and biology of cutaneous human papillomavirus

Beta Human Papillomavirus and Associated Diseases

High-risk Cutaneous Squamous Cell Carcinoma

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