2009
DOI: 10.1111/j.1529-8019.2009.01227.x
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Human papillomavirus vaccines

Abstract: Cervical and other cancers linked to the human papillomavirus (HPV) are a cause of significant morbidity and mortality. Since the discovery of HPV as a cause of these cancers, there has been much research and development in the field of HPV vaccination. Two current prophylactic vaccines have proved highly effective in preventing disease because of the vaccine types. Recent advances in prophylactic and therapeutic vaccines are discussed.

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Cited by 6 publications
(8 citation statements)
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“…However, such vaccines provide limited type-specific protection and their mass production is less efficient with a high processing time [15][16][17]. The exorbitant issues linked with the currently available vaccines to prevent HPV infection as well as the loss of efficient therapeutic vaccines have provoked extensive efforts for the development of novel vaccine strategies [18]. So far, several vaccines against HPV E6 and/or E7 oncogenes using various approaches such as protein-or DNAbased vaccines and live vaccines have been developed [3,[19][20][21].…”
Section: Research Articlementioning
confidence: 99%
“…However, such vaccines provide limited type-specific protection and their mass production is less efficient with a high processing time [15][16][17]. The exorbitant issues linked with the currently available vaccines to prevent HPV infection as well as the loss of efficient therapeutic vaccines have provoked extensive efforts for the development of novel vaccine strategies [18]. So far, several vaccines against HPV E6 and/or E7 oncogenes using various approaches such as protein-or DNAbased vaccines and live vaccines have been developed [3,[19][20][21].…”
Section: Research Articlementioning
confidence: 99%
“…En un comienzo se supuso que existía solo un tipo de VPH y que la variación morfológica entre las lesiones era debido a las diferencias en el epitelio en los sitios del cuerpo en los cuales las lesiones se presentaban. Años más tarde, el rol oncogénico del VPH se hizo manifiesto cuando los tipos 16, 18, y posteriormente los tipos 31 y 45, se asociaron al desarrollo de carcinoma de mucosas, en especial del carcinoma de cérvix (2) . En la práctica clínica se puede apreciar esta capacidad oncogénica en la piel de los pacientes aquejados por una rara genodermatosis conocida como epidermodisplasia verruciforme (EV), en los cuales se puede observar la inducción directa de neoplasias malignas, debido a que estos pacientes tienen una inusual tendencia a infectarse hasta con 20 diferentes tipos de VPH, desarrollando lesiones similares a verrugas planas en el tronco, la espalda y los brazos; curiosamente, solo los VPH tipo 5 y 8 son capaces de inducir el carcinoma en pacientes con EV, el curso de esta inducción se caracteriza por la progresión de verruga plana a carcinoma in situ y, finalmente, a neoplasia invasiva (3) .…”
Section: Virus Papiloma Humanounclassified
“…Os estudos da vacina quadrivalente com follow-up de 5 anos revelaram uma eficácia de 95,6% (IC=95%) na prevenção de infecção persistente e de 100% (IC=95%) na prevenção de doença (displasia cervical ou condilomas acuminados genitais) 1 .…”
Section: Vacinas Profilácticasunclassified
“…As vacinas profilácticas não demonstraram capacidade na erradicação de uma infecção pré-existente. No entanto, podem estimular a imunidade para outros subtipos específicos dessa vacina 1 .…”
Section: Vacinas Terapêuticasunclassified
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