Human papillomaviruses 6/11, 16/18 and 31/33/51 are not associated with squamous cell carcinoma of the urinary bladder

Westenend, Pieter J.; Stoop, J.A.; Hendriks, J. G. M.

doi:10.1046/j.1464-410x.2001.02230.x

Cited by 59 publications

(37 citation statements)

References 31 publications

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“…46 Whether HPV has a role in the carcinogenesis of bladder cancer has been debated. [47][48][49][50] Esophageal cancer (squamous cell carcinoma) has been positively associated with HPV, with a stronger association in high-risk populations, [51][52][53][54][55] but contradictory results have been reported. 56 Cigarette smoking is considered as the most important factor in the etiology of lung cancer, but detection of circulating HPV DNA in blood samples has been suggested as a risk marker for lung cancer, 57 and play a role in the carcinogenesis of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Cancer risk among patients with condylomata acuminata

Nordenvall

Chang

Adami

et al. 2006

Intl Journal of Cancer

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Condylomata acuminata have been shown to increase the risk of anogenital cancers. However, previous studies have been of limited sample size and/or short follow-up duration, which prevent precise estimates of long-term excess risk, especially for specific cancer sites. We estimated the risk of specific cancers in a large cohort of hospitalized patients with condylomata acuminata, as recorded in the Swedish Inpatient Register between 1965 and 1999. Altogether, 10,971 patients (1,685 men and 9,286 women) were followed through 1999 for a median of 13 years. The standardized incidence ratio (SIR)-the ratio of the observed number of cancers to the number expected on the basis of the incidence in the Swedish population at large-was used as a measure of relative risk. After excluding the first-year of follow-up, we observed 43 cases of anogenital cancer in women, and 7 cases in men. Risks were elevated for cancers of the vulva (N 5 13, SIR 5 10.2, 95% confidence interval (CI) 5 5.4-17.4), vagina (N 5 4, SIR 5 12.0, 95% CI 5 3.3-30.7) and penis (N 5 5, SIR 5 21.9, 95% CI 5 7.1-51.2). There was a moderate excess risk of cervical cancer in situ (N 5 259, SIR 5 1.9, 95% CI 5 1.7-2.1), but not invasive cervical cancer. Excess risks of esophageal, buccal cavity, nonmelanoma skin, lung and bladder cancers, and Hodgkin and non-Hodgkin lymphoma, were also observed in both men and women. In conclusion, condylomata acuminata are strongly associated with increased risk of cancers of the vulva, vagina, penis and anus, as well as some nonanogenital malignancies, but not invasive cervical cancer. ' 2006 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Cancer risk among patients with condylomata acuminata

Nordenvall

Chang

Adami

et al. 2006

Intl Journal of Cancer

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“…[12][13][14] Maloney et al 12 showed the presence of HPV 18 by PCR in 1 of 22 patients (4.5%) with squamous cell carcinoma while Shigehara et al 13 and Westenend et al 14 did not identify HPV in any of their 4 and 16 cases, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 An intriguing issue has been the possible association of the virus with bladder squamous cell carcinoma. The few published studies [11][12][13][14] on this relationship have shown a low frequency of HPV detection, implying that HPV is not likely to have a major role in the development of bladder squamous cell carcinoma. However, the positive cases identified in the literature suggest that under certain circumstances, such as immunosuppression 12 and persistent condylomatous infection, 11,15,16 the virus may exert its oncogenic activity in the bladder.…”

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confidence: 99%

Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection

et al. 2012

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Squamous cell carcinomas of the urinary bladder are rare in the Western world; the majority of cases are reported in countries endemic to Schistosoma parasitic infections. Unlike squamous tumors of the uterine cervix or oropharynx, the human papillomavirus (HPV) is not commonly associated with bladder squamous cell carcinomas. We report on two cases of HPV-positive urothelial carcinomas of the urinary bladder with extensive squamous differentiation showing the typical basaloid, poorly differentiated morphology of HPV-associated tumors. These occurred in patients with neurogenic bladders who had long-standing histories of selfcatheterization with tumors that tested positive for HPV by in situ hybridization. A retrospective review of our institutional database revealed four additional patients with bladder tumors showing squamous differentiation arising in the setting of neurogenic bladder. Review of these cases showed the more common welldifferentiated keratinizing appearance of squamous cell carcinomas of the bladder. These tumors showed only patchy positivity for p16 immunohistochemical stain (not the diffuse strong staining seen in HPV-positive tumors), and the one tested case was negative for HPV by in situ hybridization. HPV infection and neurogenic bladder have been independently associated with increased risk of developing carcinoma in the urinary bladder; however, this is the first report of squamous tumors arising in the setting of concurrent neurogenic bladder and HPV infection. The morphology of these tumors is similar to that of other high-risk HPV-associated squamous carcinomas with a basaloid, poorly differentiated appearance and little to no keratin formation. Modern Pathology (2012) 25, 1534-1542; doi:10.1038/modpathol.2012.112; published online 6 July 2012 Keywords: HPV; neurogenic bladder; squamous cell carcinoma; urothelial cancerThe human papillomavirus (HPV) has an important role as a human carcinogen, with an estimated 10% of cancers worldwide attributed to it. 1 HPV is a small circular double-stranded DNA virus with more than 100 different types described to date. 2 The potential of the virus to cause malignant or benign lesions dictates its classification into low-risk (6,11,40,42, and so on) or high-risk (16,18,31,33,45,51, and so on) types. The prototypical model for carcinogenesis is squamous cell carcinoma of the uterine cervix, in which nearly all such carcinomas are associated with HPV infection. 3,4 The oncogenic role of HPV is also well established for a subset of squamous cell carcinomas in the vulva, 5 penis, 6 anus, 7 and oropharynx. 8 The possible role of HPV infection in bladder tumors has not been completely elucidated as HPV detection rates vary widely from 0 to 100%, depending on the study. 9,10 An intriguing issue has been the possible association of the virus with bladder squamous cell carcinoma. The few published studies 11-14 on this relationship have shown a low frequency of HPV detection, implying that HPV is not likely to have a major role in the development of bladd...

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“…In contrast, other studies reported no detection of HPV [7,26,33]. Several explanations of this variability have been proposed, including sampling problems, contamination, sensitivity of the detection systems, and geographic variation [34]. It seems that geographical location has an impact on the association between HPV and bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus detection in Moroccan patients with bladder cancer

Berrada

Albouzidi

Ameur

et al. 2013

J Infect Dev Ctries

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Introduction: Human papillomavirus (HPV) is associated with more human cancers than any other virus. Many studies have investigated the association between bladder cancer and HPV but the results remain controversial. The aim of the present study is to evaluate whether HPV have an etiological role in bladder carcinogenesis among Moroccan patients. Methodology: Forty-eight fresh biopsies (43 bladder tumors and 5 non-tumor samples) were collected for this purpose. Nested PCR with the consensus MY09/MY11 and GP5

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Human papillomaviruses 6/11, 16/18 and 31/33/51 are not associated with squamous cell carcinoma of the urinary bladder

Cited by 59 publications

References 31 publications

Cancer risk among patients with condylomata acuminata

Cancer risk among patients with condylomata acuminata

Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection

Human papillomavirus detection in Moroccan patients with bladder cancer

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