Human parainfluenza virus infection in severe acute respiratory infection cases in Beijing, 2014‐2016: A molecular epidemiological study

Pan, Yang; Zhang, Yi; Shi, Weixian; Peng, Xiaomin; Cui, Shujuan; Zhang, Daitao; Lu, Guilan; Liu, Yimeng; Wu, Shanshan; Yang, Peng; Wang, Quanyi

doi:10.1111/irv.12514

Cited by 33 publications

(30 citation statements)

References 14 publications

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“…The most common cause of SARI in children is viral infections [5][6][7][8][9][10], including influenza viruses A and B (Flu A/B); respiratory syncytial virus (RSV); adenovirus (ADV); parainfluenza virus (PIV) 1-3; picornavirus (PIC), which mainly includes human rhinovirus (RV) and human enterovirus (EV); human coronaviruses (HCoV), which includes OC43, 229E, NL63, and HKU; human bocavirus (HBoV); and human metapneumovirus (HMPV). Although the viral and epidemiological profiles of pediatric patients with SARI vary among countries [4,[7][8][9][10][11][12][13][14][15], few studies have comprehensively compared the viral and epidemiological profiles of pediatric patients with SARI in different geographic areas or climate zones within the same country, such as China.…”

Section: Introductionmentioning

confidence: 99%

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

Zhao

Shen

et al. 2019

BMC Infect Dis

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Background No comparison data have been reported on viral and epidemiological profiles of hospitalized children with severe acute respiratory infection (SARI) in Beijing or Shanghai, China. Methods We collected 700 nasopharyngeal aspirates (NPA) from hospitalized children with SARI in Beijing (northern China) and Shanghai (southern China). Multiple respiratory viruses (including 15 common viruses) were screened by validated polymerase chain reaction (PCR) or real-time reverse transcription-PCR assays and confirmed by sequencing. Demographic data and the distribution of viral infections were also examined. Results Of 700 samples, 547 (78.1%) tested positive for viral infections. The picornaviruses (PIC), which included rhinovirus (RV) and enterovirus (EV), were the most common (34.0%), followed by respiratory syncytial virus (RSV) (28.3%), human bocavirus (HBoV) (19.1%), adenovirus (ADV) (13.7%), human coronaviruses (HCoV) (10.7%), influenza A and B (8.9%), parainfluenza virus (PIV 1–3) (7.9%), and human metapneumovirus (HMPV) (5.0%). PIC (RV/EV) and RSV were the most prevalent etiological agents of SARI in both cities. The total and age-matched prevalence of RSV, HCoV, and hMPV among SARI children under 5 years old were significantly higher in Beijing than in Shanghai. Different age and seasonal distribution patterns of the viral infections were found between Beijing and Shanghai. Conclusions Viral infection was tested and shown to be the most prevalent etiological agent among children with SARI in either the Beijing or the Shanghai area, while showing different patterns of viral and epidemiological profiles. Our findings provide a better understanding of the roles of geographic location and climate in respiratory viral infections in hospitalized children with SARI.

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Section: Introductionmentioning

confidence: 99%

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

Zhao

Shen

et al. 2019

BMC Infect Dis

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“…In China, pneumonia is the main cause of child hospitalization which brings about increased burden for outpatient clinic [2,3]. Respiratory virus infections are increasingly recognized as playing a major role in the burden of severe acute respiratory illness in many countries due to expanded global surveillance and improved molecular diagnostic testing [4][5][6][7]. It is reported that among children with pneumonia, 4-10% are caused by human adenovirus (HAdV).…”

Section: Introductionmentioning

confidence: 99%

Human adenovirus load in respiratory tract secretions are predictors for disease severity in children with human adenovirus pneumonia

Xie

Zhang

Zhou

et al. 2018

Virol J

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BackgroundPneumonia is a serious public health issue and is concerned around the world. This study is to investigate the association between viral load in children with human adenovirus (HAdV) pneumonia and disease severity.MethodsA total of 1313 cases of children hospitalized in Hunan Provincial People’s Hospital due to community acquired pneumonia (CAP) from April 2011 to May 2014 were enrolled in this study. Samples of nasopharyngeal aspirate were collected for the cohort. WHO criteria for CAP grading was emerged for pneumonia severity classification. Real-time fluorescence quantitative PCR (qRT-PCR) was used to detect 12 kinds of respiratory viruses. HAdV types were identified by nested PCR. The relationship between HAdV load and severity of disease was there by analyzed.ResultsFinally, 174 cases (174/1313, 13.3%) were positive for HAdV, and HAdV type 7 (HAdV-7) was the main serotype (76/174, 43.7%). Among the 174 cases, 70 cases were with HAdV infection alone and 104 cases were accompanied by other viruses. The patients were divided into mild pneumonia group (n = 108 cases) and severe pneumonia group (n = 66 cases). HAdV load of children in severe pneumonia group was higher than that in mild pneumonia group. Similar result was obtained in the 70 cases with HAdV infection alone after subgrouping. Relevant factors analysis results showed that severe pneumonia children presented lower onset age, more prone to fever, longer fever time, and longer hospital stay compared with that of mild pneumonia children. Children with HAdV-7 infection developed more frequently severe pneumonia. Multivariate regression analysis showed that HAdV load, age, and fever time were risk factors for pneumonia severity.ConclusionThe severity of HAdV infection is significantly correlated with viral load and serotype.

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“…Phylogenetic history of several respiratory viruses isolated from China in recent years have been well established, including the influenza virus ( Wang et al, 2018 ; Yang et al, 2018 ), the PIV ( Pan et al, 2017 ) and the RSV ( Liu et al, 2014 ; Zou et al, 2016 ). The information about adenoviral evolutionary history in China was limited to outbreak reports and novel strains identification ( Lu et al, 2014 ; Li et al, 2018 ), leaving a gap for circulating stains among adult patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Common Respiratory Viral Infections and Identification of Adenovirus in Hospitalized Adults in Harbin, China 2014 to 2017

Wang

Dong

et al. 2018

Front. Microbiol.

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Background: Respiratory infections pose a great challenge in global health, and the prevalence of viral infection in adult patients has been poorly understood in northeast China. Harbin is one of the major cities in northeast China, and more than half of any given year in Harbin is occupied by winter. To reveal the viral etiology and seasonality in adult patients from Harbin, a 4-year consecutive survey was conducted in Harbin, China.Methods: From January 2014 to December 2017, specimens were obtained from adult patients admitted to the Second Affiliated Hospital of Harbin Medical University with lower respiratory tract infections. Sputum samples were examined by direct immunofluorescence assays to detect seven common respiratory viruses, including influenza virus (type A and B), parainfluenza virus (type 1 to 3), respiratory syncytial virus and adenovirus. Adenovirus positive samples were seeded onto A549 cells to isolate viral strains. Phylogenetic analysis was conducted on the highly variable region of adenoviral hexon gene.Results: A total of 1,300 hospitalized adult patients with lower respiratory tract infections were enrolled, in which 189 patients (14.5%) were detected as having at least one viral infection. The co-infection rate in this study was 25.9% (49/189). The dominant viral pathogen from 2014 to 2017 was parainfluenza virus, with a detection rate of 7.2%, followed by influenza virus, respiratory syncytial virus and adenovirus. Based on the climate seasons determined by daily average temperature, the highest overall viral detection rate was detected in spring (22.0%, 52/236), followed by winter (13.4%, 109/813), autumn (11.4%, 13/114) and summer (10.9%, 15/137). Adenovirus type 3 strains with slight variations were isolated from positive cases, which were closely related to the GB strain from the United States, as well as the Harbin04B strain isolated locally.Conclusion: This study demonstrated that common respiratory viruses were partially responsible for hospitalized lower respiratory tract infections in adult patients from Harbin, China, with parainfluenza virus as the dominant viral pathogen. Climate seasons could be rational indicators for the seasonality analysis of airborne viral infections. Future surveillance on viral mutations would be necessary to reveal the evolutionary history of respiratory viruses.

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Human parainfluenza virus infection in severe acute respiratory infection cases in Beijing, 2014‐2016: A molecular epidemiological study

Cited by 33 publications

References 14 publications

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

Human adenovirus load in respiratory tract secretions are predictors for disease severity in children with human adenovirus pneumonia

Prevalence of Common Respiratory Viral Infections and Identification of Adenovirus in Hospitalized Adults in Harbin, China 2014 to 2017

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