Human parvovirus B19 infection associated with acute hepatitis

Yoto, Yuko; Kudoh, Tooru; Haseyama, Keiji; Suzuki, Nobuhiro; Chiba, Shunzo

doi:10.1016/s0140-6736(96)91348-3

Cited by 150 publications

(89 citation statements)

References 6 publications

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“…The results obtained for case 3 corroborate other data providing evidence that parvovirus B19 may be a cause of hepatic dysfunction by mechanisms that are not yet elucidated (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Some authors suggest a direct effect of parvovirus B19 infection after interaction with its cellular receptors, the erythrocyte P antigens, which are present on erythroid and liver cells (29).…”

Section: Discussionsupporting

confidence: 85%

“…Some authors suggest a direct effect of parvovirus B19 infection after interaction with its cellular receptors, the erythrocyte P antigens, which are present on erythroid and liver cells (29). Furthermore, B19 DNA has been detected in liver tissue from fulminant hepatic failure cases (5). The time course of hepatitis in case 3 is also consistent with infectious hepatitis in which the B19 infection was resolved.…”

Section: Discussionmentioning

confidence: 82%

“…Liver dysfunctions associated with parvovirus B19 have been described by several authors, especially involving acute hepatitis cases (3)(4)(5)(6)(7)(8)(9)(10)(11)(12), and the transmission of parvovirus B19 to patients with liver diseases has possibly led to exacerbations of disease in patients with cirrhosis (13) and liver transplant (14).…”

Section: Introductionmentioning

confidence: 99%

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Detection of human parvovirus B19 in a patient with hepatitis

Pinho

Alves

Vieira

et al. 2001

Braz J Med Biol Res

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Parvovirus B19 has been associated by some investigators with cases of severe hepatitis. The aim of the present study was to determine the presence of active parvovirus B19 infection among 129 Brazilian patients with non-A-E hepatitis. The patients were assayed for antibodies against parvovirus B19, IgM class, by ELISA. In IgM-positive cases, parvovirus B19 DNA was assayed by PCR in serum and liver tissue and parvovirus VP1 antigen in liver tissue was assayed by immunohistochemistry. Antibodies against parvovirus B19, IgM class, were detected in 3 (2.3%) of 129 patients with non-A-E hepatitis. Previous surgery and blood transfusions were reported by these 3 patients. One patient was a 56-year-old female with severe hepatitis, with antimitochondrial antibody seropositivity and submassive necrosis at liver biopsy, who responded to corticosteroid therapy. Strong evidence for active parvovirus B19 infection was found in this patient, with parvovirus B19 DNA being detected by PCR in liver tissue. Furthermore, parvovirus VP1 antigen was also detected in liver tissue by immunohistochemistry. The other two IgM-positive patients were chronic hepatitis cases, but active infection was not proven, since neither viral DNA nor antigen were detected in their liver tissues. This and other reports suggest a possible relation between parvovirus B19 infection and some cases of hepatitis.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Detection of human parvovirus B19 in a patient with hepatitis

Pinho

Alves

Vieira

et al. 2001

Braz J Med Biol Res

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“…Despite this, however, there are several published reports of acute parvovirus B19 infection in adults associated with the development of acute hepatitis [8][9][10][11] . Interestingly, in virtually every case reported the patients have had a complete and spontaneous remission.…”

Section: Discussionmentioning

confidence: 99%

Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation

Krygier¹

2009

WJG

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Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation.

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“…B19 is the causative agent of erythema infectiosum (fifth disease), hydrops fetalis, and transient aplastic anemia (1,86). Several studies disclosed an association between B19 and a variety of diseases (43,48,63,80), such as arthritis (56, 77), vasculitic syndromes (19, 24, 31, 80), hepatitis (27,36,38,75,85), and neurological disorders (2, 85). Specifically, B19 infections have been observed to be associated with acute and chronic myocarditis (13,16,30,44,53,(58)(59)(60)71).…”

mentioning

confidence: 99%

Phospholipase A2 Activity-Dependent Stimulation of Ca ²⁺ Entry by Human Parvovirus B19 Capsid Protein VP1

Lupescu¹,

Bock

Lang

et al. 2006

J Virol

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Recent reports demonstrated an association of human parvovirus B19 with inflammatory cardiomyopathy (iCMP), which is accompanied by endothelial dysfunction. As intracellular Ca 2؉ activity is a key regulator of cell function and participates in mechanisms leading to endothelial dysfunction, the present experiments explored the effects of the B19 capsid proteins VP1 and VP2. A secreted phospholipase A2 (PLA2)-like activity has been located in the VP1 unique region of the B19 minor capsid protein. As PLA2 has recently been shown to activate the store-operated or capacitative Ca 2؉ channel I CRAC , we analyzed the impact of the viral PLA2 motif on Ca 2؉ entry. We cloned the VP1 and VP2 genes isolated from a patient suffering from fatal B19 iCMP into eukaryotic expression vectors. We also generated a B19 replication-competent plasmid to demonstrate PLA2 activity under the control of the complete B19 genome. After the transfection of human endothelial cells (HMEC-1), cytosolic Ca Human parvovirus B19, a nonenveloped virus of about 22 to 24 nm in diameter, is a member of the genus Erythrovirus within the family of Parvoviridae (35). B19 infection occurs frequently in humans, and this is documented by the high prevalence of specific immunoglobulin G (IgG) antibodies in young children (5% to 15%), adults (60%), and seniors older than 69 years (85%) (15). B19 is the causative agent of erythema infectiosum (fifth disease), hydrops fetalis, and transient aplastic anemia (1,86). Several studies disclosed an association between B19 and a variety of diseases (43,48,63,80), such as arthritis (56, 77), vasculitic syndromes (19, 24, 31, 80), hepatitis (27,36,38,75,85), and neurological disorders (2, 85). Specifically, B19 infections have been observed to be associated with acute and chronic myocarditis (13,16,30,44,53,(58)(59)(60)71). Moreover, the development of endothelial and isolated left ventricle diastolic dysfunction has been associated with B19 infection (81). During pregnancy, parvovirus B19 infection may cause maternal and fetal myocarditis, congenital abnormalities, stillbirth, and abortion (10, 21, 39, 61). The particularly severe course of the antenatal disease may relate to the preference of B19 for proliferating tissues (79).The cellular receptor for B19 infection has been regarded as a blood group P antigen based on the failure of B19 infection in a patient with a hereditary P antigen defect (12). The P antigen is necessary for B19 binding but not sufficient for virus entry into cells. In this regard, the ␣5␤1 integrin and the recently identified Ku80 autoantigen act as cellular coreceptors for human parvovirus B19 infection (57, 82). Therefore, target cells of B19 are mainly erythroid progenitor cells expressing high levels of P antigen as well as the coreceptors ␣5␤1 integrin and Ku80 autoantigen. However, nonerythroid cell lineages, such as fetal myocytes, follicular dendritic cells, and endothelial cells can be infected by B19 (12,28,29,57,82). We have recently localized B19 genomes in endothelial cells of my...

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Human parvovirus B19 infection associated with acute hepatitis

Cited by 150 publications

References 6 publications

Detection of human parvovirus B19 in a patient with hepatitis

Detection of human parvovirus B19 in a patient with hepatitis

Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation

Phospholipase A2 Activity-Dependent Stimulation of Ca ²⁺ Entry by Human Parvovirus B19 Capsid Protein VP1

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Human parvovirus B19 infection associated with acute hepatitis

Cited by 150 publications

References 6 publications

Detection of human parvovirus B19 in a patient with hepatitis

Detection of human parvovirus B19 in a patient with hepatitis

Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation

Phospholipase A2 Activity-Dependent Stimulation of Ca 2+ Entry by Human Parvovirus B19 Capsid Protein VP1

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Phospholipase A2 Activity-Dependent Stimulation of Ca ²⁺ Entry by Human Parvovirus B19 Capsid Protein VP1