Human parvovirus B19 nosocomial outbreak in healthcare personnel in a paediatric ward at a national tertiary referral centre in Thailand

Healthcare-Associated Viral Infections: Considerations for Nosocomial Transmission and Infection Control

“…Nosocomial transmission of parvovirus B19 infections can occur from person to person through droplet transmission and, rarely, through blood products [57]. Healthcare-associated outbreaks of parvovirus B19 affecting both patients and hospital personnel have been described [58].…”

Association between parvovirus B19 virus and childhood acute lymphoblastic leukemia: A cross-sectional study in Tehran; Iran

“…Vertical transmission is common following maternal infection (nonimmune mothers) {2} There is still no evidence of fetal teratogenic effects with parvovirus B19, but fetal infection may be asymptomatic, or severe infection and sequelae like hydrops fetalis, or fetal death [1,2]. Parvovirus B19contaminated blood products increases the risk of infection [3]. Nosocomial outbreaks of parvovirus B19 rarely occurred among Thailand healthcare personnel (HCP) with more importance in susceptible pregnant women [3].…”

“…Parvovirus B19contaminated blood products increases the risk of infection [3]. Nosocomial outbreaks of parvovirus B19 rarely occurred among Thailand healthcare personnel (HCP) with more importance in susceptible pregnant women [3]. Persistent viral infection is responsible for an autoimmune response and clinical symptoms can mimic autoimmune inflammatory disorders [4].…”

“…Molecular mimicry between Parvovirus B19 and host is the main mechanism in autoimmune response. For viral eradication no immunoglobulins, antiviral or vaccination are available until yet [1,3,4]. But intrauterine transfusion in selected hydrops fetalis may be lifesaving.…”

“…But intrauterine transfusion in selected hydrops fetalis may be lifesaving. Parvovirus B19 diagnosis is mainly through serology and polymerase chain reaction [1][2][3][4].…”