Human pathogenic <i>Mycobacterium kansasii</i> (former subtype I) with zoonotic potential isolated from a diseased indoor pet cat, Japan

Fukano, Hanako; Terazono, Tsukasa; Hirabayashi, Aki; Yoshida, Mitsunori; Suzuki, Masato; Wada, Shinpei; Ishii, Norihisa; Hoshino, Yoshihiko

doi:10.1080/22221751.2021.1878935

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…kansasii is ubiquitous in the environment, yet is a rare pathogen in livestock and wildlife [4]. The clinical presentation of M. kansasii infection in animal hosts is highly variable, ranging from asymptomatic infection to overt clinical disease that may feature chronic weight loss, granulomatous pneumonia, bronchial lymphadenopathy, or cutaneous lesions [15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Disease associated with M. kansasii infection has been reported in wild boar (Sus scrofa) [27], free-ranging black-tailed deer (Odocoileus hemionus columbianus) [17] and white-tailed deer (Odocoileus virginianus) [25], bonteboks (Damaliscus pygargus dorcas) [20], laboratory rhesus monkeys (Macaca mulatta) [22], captive Florida manatees (Trichechus manatus) [16], domestic goats (Capra hircus) [15], cattle (Bos taurus) [19,23,24,28], domestic cats (Felis catus) [26], Sichuan takins (Budorcas taxicolortibetana) [21], siamangs (Hylobates syndactylus) [21], and alpacas (Vicugna pacos) [18].…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium kansasii Infection in a Farmed White-Tailed Deer (Odocoileus virginianus) in Florida, USA

Cottingham,

Cheng,

de Oliveira Viadanna

et al. 2024

Animals

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A 7-year-old farmed white-tailed deer doe was transported to a Levy County, Florida property and began to decline in health, exhibiting weight loss and pelvic limb weakness. The doe prematurely delivered live twin fawns, both of which later died. The doe was treated with corticosteroids, antibiotics, gastric cytoprotectants, and B vitamins but showed no improvement. The doe was euthanized, and a post mortem examination was performed under the University of Florida’s Cervidae Health Research Initiative. We collected lung tissue after the animal was euthanized and performed histological evaluation, using H&E and Ziehl–Neelsen (ZN) staining, and molecular evaluation, using conventional PCR, followed by Sanger sequencing. The microscopic observations of the H&E-stained lung showed multifocal granuloma, while the ZN-stained tissue revealed low numbers of beaded, magenta-staining rod bacteria inside the granuloma formation. Molecular analysis identified the presence of Mycobacterium kansasii. This isolation of a non-tuberculous Mycobacterium in a white-tailed deer emphasizes the importance of specific pathogen identification in cases of tuberculosis-like disease in farmed and free-ranging cervids. We report the first case of M. kansasii infection in a farmed white-tailed deer (Odocoileus virginianus) in Florida. Although M. kansasii cases are sporadic in white-tailed deer, it is important to maintain farm biosecurity and prevent farmed cervids from contacting wildlife to prevent disease transmission.

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Section: Introductionmentioning

confidence: 99%

Mycobacterium kansasii Infection in a Farmed White-Tailed Deer (Odocoileus virginianus) in Florida, USA

Cottingham,

Cheng,

de Oliveira Viadanna

et al. 2024

Animals

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“…The incidence of NTM infections is increasing at a fast pace, and there is evidence of acquired infection from environmental sources and human-tohuman transmission (Jia et al 2021). Additionally, there are instances of the zoonotic potential of NTM-mediated infections (Fukano et al 2021). Anthropogenic activities, immunocompromisation, antibiotic resistance, and lack of effective vaccines have contributed to the surge of NTM infections (Bryant et al 2016;Sur 2021).…”

Section: Introductionmentioning

confidence: 99%

The pangenome structure of human pathogen Mycobacterium kansasii

Sur

2023

Acta Biol Szeged

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The non-tuberculous Mycobacterium kansasii, is the causative agent of destructive pulmonary and extrapulmonary infections in immunocompromised persons. Incessant use of multiple antibiotics and lack of effective vaccines did little to combat M. kansasii mediated infections. Here, a bioinformatic analysis has been carried out using PanExplorer, to analyze the pangenome aimed at functional characterization of the bacterium, understanding it’s pathogenic lifestyle and recognize the factors shaping evolution and variations amongst strains. M. kansasii had a large core genome (60.2%), a small (11.9%) dispensable genome and 27.9% strain-specific genes. The core genome of M. kansasii had a high concentration of COGs (Cluster of orthologous genes) linked to energy production and conversion, amino acid transport and metabolism, nucleotide transport and metabolism, coenzyme transport and metabolism, and secondary me-tabolite biosynthesis, transport and metabolism. Interestingly, numerous genes within the core and dispensable genome were associated with pathogenesis and virulence. Noteworthy among them were type VII secretion, ESX, PP and PPE family proteins. Although, M. kansasii genomes revealed overall relatedness and conservation, genomic rearrangements caused variability within the strains. The information from this analysis could assist future microbial genomics research on M. kansasii, and further studies, e.g., concerning distinctive gene clusters, and evolution.

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“…Animal diseases are rarely caused by M. kansasii, which is much more often isolated from humans. The estimated incidence of M. kansasii in humans ranges from 2 to 118 cases per 1,000,000 people, rising to 5320 in the population of people with AIDS [13]. Humanto-human transmission is thought not to occur [14].…”

Section: Introductionmentioning

confidence: 99%

Infection of a Free-Living Wild Boar (Sus scrofa) with a Bacterium from the Mycobacterium kansasii Complex

Radulski

Krajewska‐Wędzina

Lipiec

et al. 2022

Animals

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The most numerous group of bacteria in the genus Mycobacterium is the nontuberculous mycobacteria. Currently, over 200 species of bacteria have been classified as belonging to this group, of which approximately 30 are pathogenic to humans and animals. Mycobacterium kansasii complex numbers among these pathogenic species. The submandibular lymph nodes of a wild boar shot by a hunter were examined in order to confirm or exclude infection with bacteria of the genus Mycobacterium. In culture, a bacterial isolate was obtained after 12 days of incubation on Petragnani and Stonebrink media. A multiplex PCR clearly indicated that the isolate was a nontuberculous mycobacterium. The results of species identification attempts via both molecular biology methods and mass spectrometry confirmed that the isolated strain belonged to MKC. The described case of a wild boar infection with MKC is the first documented case in Poland and only the second in Europe, and in confirming the presence of this pathogen among free-living animals, this report implies that MKC is of great concern. Our research elucidates some specifics of wild boar mycobacteriosis and may be used to instill awareness in the public of the dangers of dressing hunt prey or consuming its meat in ignorance of safe procedures, which can contribute to the transmission of the pathogen to humans.

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Human pathogenic Mycobacterium kansasii (former subtype I) with zoonotic potential isolated from a diseased indoor pet cat, Japan

Cited by 5 publications

References 26 publications

Mycobacterium kansasii Infection in a Farmed White-Tailed Deer (Odocoileus virginianus) in Florida, USA

Mycobacterium kansasii Infection in a Farmed White-Tailed Deer (Odocoileus virginianus) in Florida, USA

The pangenome structure of human pathogen Mycobacterium kansasii

Infection of a Free-Living Wild Boar (Sus scrofa) with a Bacterium from the Mycobacterium kansasii Complex

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