Human Physiology: Water and Electrolyte Homeostasis

Natochin, Yu. V.

doi:10.1134/s0362119718030118

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…При этом отмечается, что стабильность физико-химических параметров жидкостей внутренней среды наиболее четко отражает степень влияния факторов внешней среды на организм по сравнению, например с изменением уровня гормонов, диапазоном колебаний концентрации веществ в моче [19].…”

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Assessment of the Body Response to Snowmelt Water Consumption in Military Personnel Serving in the Arctic Based on Blood Parameters

Rakhmanov¹,

Narutdinov²,

Богомолова³

et al. 2023

PH&LE

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Introduction: Stability of physicochemical parameters of body fluids reflects the degree of influence of environmental factors on the body. Objective: To assess the body response to snowmelt water consumption for drinking purposes in military personnel serving in the Arctic based on blood parameters. Material and methods: The study was conducted in summer 2022. We took snowmelt water samples for chemical analysis and venous samples from 51 servicemen for a complete blood count and electrolyte measurements. Results: Snowmelt testing showed that the levels of iron were 1.2–1.6, copper – 22.2, zinc – 52.1, sodium – 11.6 to 21.9, magnesium – 5.7 to 29.1, and calcium – 9.0 to 34.1 times lower than reference concentrations. Potassium levels were negligible. The length of service of the study subjects in the Arctic above the 76th parallel North was 5.7 ± 0.3 years. Blood test results showed low or lower normal values of erythrocyte count in 39.2 %, hematocrit – in 19.6 %, and mean hemoglobin – in 13.7 % of the military personnel. A high mean corpuscular volume was detected in 17.6 % of them. The proportion of stab neutrophils in the sample was 0.55 ± 0.04 % with the normal range of 1 to 6 %. The electrolyte imbalance was evidenced by high serum potassium levels in 21.6 %, a lack of ionized calcium and magnesium in 29.4 % and 17.6 %, respectively, and sodium, phosphorus, and chlorine levels at the lower limit of the normal range in 29.4 to 47.1 % of the examined. Conclusions: Snowmelt water contains low concentrations of inorganic chemicals. Its long-term daily consumption for drinking purposes leads to electrolyte imbalance in the body, such as hypotonic water overload, and is likely to affect nonspecific resistance.

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Assessment of the Body Response to Snowmelt Water Consumption in Military Personnel Serving in the Arctic Based on Blood Parameters

Rakhmanov¹,

Narutdinov²,

Богомолова³

et al. 2023

PH&LE

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Assessment of formed elements, vitamins B12, folic acid and iron in the blood of men with mental work

Narutdinov,

Rakhmanov,

Bogomolova

et al. 2024

Sanitary Doctor

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Changes in the components of the hemogram respond to the influence of living and working conditions. The goal is to assess blood parameters, vitamins B12 and B9 in men of mental work. A random sample of blood was collected from men permanently residing in Krasnoyarsk (n = 58). We assessed the degree of anthropogenic load and working conditions according to the degree of harmfulness and danger. A clinical blood test was performed, and the state of the body’s nonspecific adaptive reactions was assessed using lymphocytes. Vitamins B12, B9, and iron were determined. In terms of intellectual, emotional stress and work schedule, the work is harmful (3.3). Signs of anemia were revealed (decrease in erythrocytes in 12.1 %, hemoglobin in 10.3 %, hematocrit in 10.3 %), macrocytic (average erythrocyte volume increased in 10.3 %), hypochromic (reduced average hemoglobin concentration in erythrocyte in 22.3 %), developing due to deficiency of vitamin B12 (in 67.2 %) and B9 (in 32.8 %), iron (below the median in 51.7 %). The proportion of rod-nuclear neutrophils was reduced, the proportion of eosinophils (in 13.8 %) and monocytes (in 25.6 %) was increased, indicating sensitization, allergization, a decrease in nonspecific defense mechanisms and the presence of an inflammatory reaction in the body. The presence of stress in the body was evidenced by indicators of nonspecific adaptive reactions of the body (reactivation in 27.6 %), an increase in the proportion of monocytes in 25.6 % of those examined. It can be assumed that an environmentally unfavorable living environment and hard work in conditions of inadequate provision of the body with cyanocobalamin, folic acid and iron negatively affect the composition of the blood, which, in turn, can affect health.

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Comparative Analysis of Red Blood Cells and Blood Levels of Iron and Vitamins B12 and B9 in Men Working in Different Climate Zones

Rakhmanov,

Narutdinov,

Bogomolova

et al. 2024

PH&LE

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Introduction: Vitamin and mineral deficiencies, inter alia, cause changes in hematological parameters. Objective: To compare characteristics of red blood cells and blood levels of iron and vitamins B12 and B9 in men working in different climate zones. Material and methods: In June–July of the years 2022 and 2023, we assessed nutritional patterns and blood parameters characterizing red blood cells and the levels of iron, vitamins B12 and B9 in healthy male military personnel residing in the Arctic (Group 1, n = 51), Subarctic (Group 2, n = 54), and temperate (Group 3, n = 58) climate zones. Results: In the summertime, we established a decreased red blood cell count in 39.4 %, 14.8 %, and 10.3 % of the subjects (20, 8, and 6 men), hematocrit – in 19.6 %, 9.3 %, and 10.3 % (10, 5 and 6 men), and mean corpuscular hemoglobin concentration – in 21.6 %, 16.7 %, and 27.6 % (12, 9, and 16 men), but an increased mean corpuscular volume in 17.8 %, 13.0 %, and 10.3 % (9, 7, and 6 men) and corpuscular hemoglobin – in 11.8 %, 22.2 %, and 24.1 % (6, 12, and 14 men) in the Arctic, Subarctic and temperate zones, respectively. Besides, in the Subarctic and temperate zones, lower hemoglobin was measured in 7.4 % and 10.3 % of the examined (4 and 6 men). We observed vitamin B12 deficiency in 100.0 %, 73.6 %, and 67.2 % (51, 40, and 39 men) and vitamin B9 deficiency – in 89.8 %, 81.2 %, and 44.8 % (46, 44, and 26 men) of the subjects serving in the Arctic, Subarctic and temperate zones, respectively. Signs of anemia in the Arctic and Subarctic residents developed against the background of vitamin B12 and folic acid deficiency; in the temperate zone, both single and combined cyanocobalamin and folic acid deficiencies were likely. The mean corpuscular hemoglobin concentration and mean corpuscular volume up to 100 fL did not exclude the regenerative phase of iron deficiency anemia.

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Human Physiology: Water and Electrolyte Homeostasis

Cited by 3 publications

References 12 publications

Assessment of the Body Response to Snowmelt Water Consumption in Military Personnel Serving in the Arctic Based on Blood Parameters

Assessment of the Body Response to Snowmelt Water Consumption in Military Personnel Serving in the Arctic Based on Blood Parameters

Assessment of formed elements, vitamins B12, folic acid and iron in the blood of men with mental work

Comparative Analysis of Red Blood Cells and Blood Levels of Iron and Vitamins B12 and B9 in Men Working in Different Climate Zones

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