Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase

Laurent, Lætitia; Deroy, Kathy; St‐Pierre, Joey; Côté, Francine; Sanderson, J. Thomas; Vaillancourt, Cathy

doi:10.1016/j.biochi.2017.07.008

Cited by 49 publications

(37 citation statements)

References 27 publications

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“…While human placenta expresses both isoforms (1 and 2) of TPH and IDO (Sedlmayr et al, 2014;Laurent et al, 2017;Ranzil et al, 2019), we found that TPH1 and IDO1 are predominant throughout gestation. Specifically, IDO1 ( Figure 3C) levels in the first-trimester and term placenta exceeded those of IDO2 (Supplementary Figure 1B, Additional File 1) by 30-and 11-fold, respectively.…”

Section: Relative Gene Expression Analysis Of Trp Metabolic Pathways mentioning

confidence: 59%

Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation

Karahoda

Abad

Horackova

et al. 2020

Front. Cell Dev. Biol.

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Section: Relative Gene Expression Analysis Of Trp Metabolic Pathways mentioning

confidence: 59%

Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation

Karahoda

Abad

Horackova

et al. 2020

Front. Cell Dev. Biol.

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“…In the non-pregnant state, melatonin and serotonin are primarily produced by the pineal gland and the brain, respectively. However, the enzymes involved in melatonin and serotonin biosynthesis are also expressed by the human placenta throughout gestation (Iwasaki et al, 2005 ; Soliman et al, 2015 ; Laurent et al, 2017 ). The mouse placenta similarly expresses the enzymes needed for serotonin synthesis (Wu et al, 2016 ), although work is required to assess if melatonin synthesizing enzymes are also expressed.…”

Section: Placental Hormones That Mediate Maternal Adaptations To Pregmentioning

confidence: 99%

The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation

et al. 2018

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During pregnancy, the mother must adapt her body systems to support nutrient and oxygen supply for growth of the baby in utero and during the subsequent lactation. These include changes in the cardiovascular, pulmonary, immune and metabolic systems of the mother. Failure to appropriately adjust maternal physiology to the pregnant state may result in pregnancy complications, including gestational diabetes and abnormal birth weight, which can further lead to a range of medically significant complications for the mother and baby. The placenta, which forms the functional interface separating the maternal and fetal circulations, is important for mediating adaptations in maternal physiology. It secretes a plethora of hormones into the maternal circulation which modulate her physiology and transfers the oxygen and nutrients available to the fetus for growth. Among these placental hormones, the prolactin-growth hormone family, steroids and neuropeptides play critical roles in driving maternal physiological adaptations during pregnancy. This review examines the changes that occur in maternal physiology in response to pregnancy and the significance of placental hormone production in mediating such changes.

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“…Abundant evidence suggests that the placenta directly synthesizes 5‐HT (Bonnin et al, 2011; Bonnin & Levitt, 2011; Huang, Zhang, Di, & Zhang, 1998; Laurent et al, 2017; Muller et al, 2017; Tuteja, Chung, & Bejerano, 2016). In the mouse placenta, the genetic machinery to produce 5‐HT increases from embryonic (E) 7.5 to 9.5 (Tuteja et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The placenta‐brain‐axis

Rosenfeld

2020

J of Neuroscience Research

156

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All mammalian species depend on the placenta, a transient organ, for exchange of gases, nutrients, and waste between the mother and conceptus. Besides serving as a conduit for such exchanges, the placenta produces hormones and other factors that influence maternal physiology and fetal development. To meet all of these adaptations, the placenta has evolved to become the most structurally diverse organ within all mammalian taxa. However, commonalities exist as to how placental responses promote survival against in utero threats and can alter the trajectory of fetal development, in particular the brain. Increasing evidence suggests that reactions of the placenta to various in utero stressors may lead to long‐standing health outcomes, otherwise considered developmental origin of health and disease effects. Besides transferring nutrients and gases, the placenta produces neurotransmitters, including serotonin, dopamine, norepinephrine/epinephrine, that may circulate and influence brain development. Neurobehavioral disorders, such as autism spectrum disorders, likely trace their origins back to placental disturbances. This intimate relationship between the placenta and brain has led to coinage of the term, the placenta‐brain‐axis. This axis will be the focus herein, including how conceptus sex might influence it, and technologies employed to parse out the effects of placental‐specific transcript expression changes on later neurobehavioral disorders. Ultimately, the placenta might provide a historical record of in utero threats the fetus confronted and a roadmap to understand how placenta responses to such encounters impacts the placental‐brain‐axis. Improved early diagnostic and preventative approaches may thereby be designed to mitigate such placental disruptions.

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Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase

Cited by 49 publications

References 27 publications

Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation

Dynamics of Tryptophan Metabolic Pathways in Human Placenta and Placental-Derived Cells: Effect of Gestation Age and Trophoblast Differentiation

The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation

The placenta‐brain‐axis

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