Human placental lactogen and unconjugated estriol concentrations in twin pregnancy: Monitoring of fetal development in intrauterine growth retardation and single intrauterine fetal death

Trapp, Michael; Kato, Keiichi; Bohnet, Heinz-G.; Gerhard, I.; Weise, Hans Chr.; Leidenberger, F.

doi:10.1016/0002-9378(86)90339-x

Cited by 15 publications

(11 citation statements)

References 6 publications

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“…Birthweight has been positively correlated with maternal pregnancy estrogen levels (27)(28)(29) but not with cord levels (29). Dizygotic twin pregnancy, which is associated with higher levels of pregnancy estrogens (30,31), has also been linked with increased breast cancer risk in the offspring, but less consistently (3,8,12). Daughters of preeclamptic pregnancies have a lower breast cancer risk (7,8,11).…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diethylstilbestrol Exposure and Risk of Breast Cancer

Palmer

Wise²,

Hatch³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

317

236

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It has been hypothesized that breast cancer risk is influenced by prenatal hormone levels. Diethylstilbestrol (DES), a synthetic estrogen, was widely used by pregnant women in the 1950s and 1960s. Women who took the drug have an increased risk of breast cancer, but whether risk is also increased in the daughters who were exposed in utero is less clear. We assessed the relation of prenatal DES exposure to risk of breast cancer in a cohort of DES-exposed and unexposed women followed since the 1970s by mailed questionnaires. Eighty percent of both exposed and unexposed women completed the most recent questionnaire. Self-reports of breast cancer were confirmed by pathology reports. Cox proportional hazards regression was used to compute incidence rate ratios (IRR) for prenatal DES exposure relative to no exposure. During follow-up, 102 incident cases of invasive breast cancer occurred, with 76 among DES-exposed women (98,591 person-years) and 26 among unexposed women (35,046 person-years). The overall age-adjusted IRR was 1.40 [95% confidence interval (95% CI), 0.89-2.22]. For breast cancer occurring at ages z40 years, the IRR was 1.91 (95% CI, 1.09-3.33) and for cancers occurring at ages z50 years, it was 3.00 (95% CI, 1.01-8.98). Control for calendar year, parity, age at first birth, and other factors did not alter the results. These results, from the first prospective study on the subject, suggest that women with prenatal exposure to DES have an increased risk of breast cancer after age 40 years. The findings support the hypothesis that prenatal hormone levels influence breast cancer risk. (Cancer Epidemiol Biomarkers Prev 2006;15(8):1509 -14)

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Section: Discussionmentioning

confidence: 99%

Prenatal Diethylstilbestrol Exposure and Risk of Breast Cancer

Palmer

Wise²,

Hatch³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

317

236

View full text Add to dashboard Cite

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“…Others have reported that estrogen levels are elevated substantially in twin pregnancies, especially dizygotic twins, compared with singletons. [16][17][18] Recently, Hsieh et a119 reported that female twins had a 40 percent increased risk of breast cancer compared with singletons; the risk was slightly higher for women whose twin was a male (odds ratio [OR] = 1.54) compared with that for women whose twin was a female (OR = 1.30). This finding further indicates that in utero exposure to high levels of endogenous estrogen might be a risk factor in the etiology of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Parental ages at birth in relation to a daughter's risk of breast cancer among female participants in the Framingham study (United States)

Cupples¹,

Rosenberg²,

Colton³

et al. 1995

Cancer Causes Control

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Data from the Framingham Heart Study, collected in Framingham, MA (United States) during 1948-86, were used to evaluate the relation of parental age at birth to the risk of breast cancer among daughters. After 38 years of follow-up, 149 breast cancer cases occurred among 2,662 women. All but two cases were confirmed by histologic report. The rate of breast cancer increased among daughters with increasing maternal age at birth up to the mid-30s, where the rate levelled off. A similar pattern was observed with paternal age. After adjustment for other confounding factors and paternal age, the rate ratios for breast cancer in daughters whose mothers were aged 26 to 31 years and 32 or more years at their birth, relative to women whose mothers were aged 25 years or younger, were 1.5 (95 percent confidence interval [CI] = 1.0-2.4) and 1.3 (CI = 0.8-2.2), respectively. However, there was no longer an association between paternal age at birth and risk of breast cancer after controlling for maternal age and other risk factors.

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“…In addition to case reports, case series (8, 10, 11, [13][14][15][16][17][18] and compiled statistics (6,19) have been published in recent years, reporting a total of 300 cases of multiple pregnancies with an antepartum death of one fetus. Based on 43 individual cases, we analysed the occurrence and prognosis of twin pregnancies with prenatal death of one fetus.…”

mentioning

confidence: 99%