Human Plasma Protein Adsorption onto Alumina Nanoparticles Relevant to Orthopedic Wear

Gibbons, John; Monopoli, Marco P.; Lundqvist, Martin; Montes-Burgos, Iker; McGrath, Eilis E.; Elia, Giuliano; Lynch, Iseult; Dawson, Kenneth A.; Stanton, Kenneth T.

doi:10.5301/jabfm.5000219

Cited by 5 publications

(7 citation statements)

References 57 publications

(72 reference statements)

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“…Some studies have proposed that the wear property of bioceramics consequences in releasing nanoparticles in vivo which provide a dissimilar biological behavior from their origin formation. Gibbons and his team (Gibbons et al, ) have recently studied the adsorption of human plasma proteins on alumina nanoparticles and monolithic substrates which were the illustrative of both wear particles and bioceramic constituents. The results presented an obvious dissimilarity between the adsorb proteins on nanosurfaces in comparison with macrosurfaces, which some studies have explained some potential reasons for it (Lynch & Dawson, , ).…”

Section: Protein Adsorption and Cell Responses To Alumina Surface Pro...mentioning

confidence: 99%

Biocompatibility of alumina‐based biomaterials–A review

Rahmati

Mozafari

2018

Journal Cellular Physiology

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In today's medicine world, alumina-based biomaterials owing to their excellent biomechanical, and biocompatibility properties play a key role in biomedical engineering. However, the literature still suffers from not having a valid database regarding the protein adsorption and subsequently cell responses to these surfaces. Proteins by adsorption on biomaterials surfaces start interpreting the construction and also arranging the biomaterials surfaces into a biological language. Hence, the main concentration of this review is on the protein adsorption and subsequently cell responses to alumina's surface, which has a wide range biomedical applications, especially in dentistry and orthopedic applications. In the presented review article, the general principles of foreign body response mechanisms, and also the role of adsorbed proteins as key players in starting interactions between cells and alumina-based biomaterials will be discussed in detail. In addition, the essential physicochemical, and mechanical properties of alumina surfaces which significantly impact on proteins and cells responses as well as the recent studies that have focused on the biocompatibility of alumina will be given. An in depth understanding of how the immune system interacts with the surface of alumina could prove the pivotal importance of the biocompatibility of alumina on its success in tissue engineering after implantation in body.

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Section: Protein Adsorption and Cell Responses To Alumina Surface Pro...mentioning

confidence: 99%

Biocompatibility of alumina‐based biomaterials–A review

Rahmati

Mozafari

2018

Journal Cellular Physiology

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“…e result showed that the nanoparticles are highly stable up to 24 h and are less toxic towards Chinese Hamster Ovary (CHO) cells [247]. e reduced toxicity may be due to the enhanced protein adsorption ability [241], especially human plasma proteins [248]. Moreover, Rajiv et al [249] evaluated the cytotoxicity and genotoxicity of cobalt, iron, silicon, and aluminum oxide nanoparticles towards human lymphocyte cell lines.…”

Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology

Egbuna

Parmar

Jeevanandam

et al. 2021

Journal of Toxicology

191

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Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review presents a comprehensive update on nanoparticles’ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. The extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others.

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“…Gulsen, Merve, and Meltem et al, worked on bio tribology of ligament wear in the knee and hip joints survey of present improvements. [10][11][12][13][14][15][16][17][18][19][20][21] This review article aimed to provide an overview of in-vitro studies at the theoretical and laboratory conditions that must be performed before clinical investigation. In the experiment, utilizing the essential standards of tribology and utilizing new techniques that would be utilized in the field of bio-tribology are investigated.…”

Section: Recent Research Of Tribology In Biomedical Engineeringmentioning

confidence: 99%

Tribology in recent biomedical engineering: a review

Alam¹

2021

MSEIJ

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Generally, tribology includes three key topics: friction, wear, and lubrication. As humanity progresses, tribology continues to make vital contributions in addressing the demands for advanced technological developments, resulting in increasing machine durability and improving the quality of life. At the point when organic systems particularly human joints for example knees, hips, and so forth which constantly move concerning each other, tribology moves toward becoming bio-tribology. Various essential bio-tribological testing phenomena can significantly influence the result of wear for the implant design and material selection. The study also found the different types of frictional losses in bio-tribology and prevention of these losses. The application of tribology in dentistry is also a growing and rapidly expanding field. In restorative dentistry, metals and alloys and ceramics and composites are generally applied to restorations and implants. The complex inter-oral environment and biomechanics, make the wear processes of artificial dental materials are very complicated and normally include abrasion, attrition, corrosion, fretting wear, and fatigue. These processes occur in various combinations to cause surface loss of materials in the mouth. Intensive research has been conducted to develop an understanding of bio tribology for the successful design and selection of implants and artificial dental materials. This study is carried out to improve the knowledge about bio-tribology and thereby guide the researchers to get their future research directives.

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Human Plasma Protein Adsorption onto Alumina Nanoparticles Relevant to Orthopedic Wear

Abstract: Proteins associated with opsonization of particles were seen to be present in the protein corona of the nanoparticles, which raises questions regarding the role of wear particles in periprosthetic tissue inflammation and aseptic loosening.

Cited by 5 publications

References 57 publications

Biocompatibility of alumina‐based biomaterials–A review

Biocompatibility of alumina‐based biomaterials–A review

Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology

Tribology in recent biomedical engineering: a review

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