Human plasma R-type vitamin B12-binding proteins. I. Isolation and characterization of transcobalamin I. TRANSCOBALAMIN III. and the normal granulocyte vitamin B12-binding protein.

Burger, R. Michael; Mehlman, C S; Allen, Robert H.

doi:10.1016/s0021-9258(19)40872-7

Cited by 60 publications

(3 citation statements)

References 25 publications

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“…ТК I и III -сывороточные белки с молекулярной массой 60-70 кДа, которые называют также связующими R-белками или кобалофилинами, -обнаруживаются в различных тканях и биологических жидкостях [25][26][27], в том числе в составе вторичных нейтрофильных гранул гранулоцитов, обладающих, как предполагается, антибактериальной активностью, что объясняет повышение их уровня при миелопролиферативных нарушениях [1,28].…”

Section: обмен витамина в 12unclassified

“…Как уже сказано, около четверти присутствующего в сыворотке крови витамина B 12 связывается ТК, тогда как оставшаяся часть связывается другими белками [27,28]. При этом определяемый автоматизированным оборудованием витамин В 12 должен освободиться от белка и преобразоваться в кобаламин.…”

Section: определение уровня витамина B 12 и диагностика его дефицитаunclassified

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Hypervitaminosis B12 - a new marker and predictor of prognostically unfavorable diseases

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Иванович²,

Dragomiretskaya

et al. 2019

Terapevticheskii arkhiv

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A high serum vitamin B12 level (hypercobalaminemia) is a underestimated anomaly. Clinically, it can be paradoxically accompanied by signs of deficiency, which are related to defects in tissue uptake of vitamin B12. The increase in the level of serum cobalamin occurs mainly in serious diseases that require early diagnosis: hemoblastosis, liver and kidney diseases, etc. This review presents data on the metabolism of vitamin B12 and the potential significance of increasing its level as a marker for the early diagnosis of these diseases.

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Section: обмен витамина в 12unclassified

Section: определение уровня витамина B 12 и диагностика его дефицитаunclassified

Hypervitaminosis B12 - a new marker and predictor of prognostically unfavorable diseases

Подзолков

Иванович²,

Dragomiretskaya

et al. 2019

Terapevticheskii arkhiv

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“…Therefore, it is urgent to identify novel molecular mechanisms and effective therapeutic targets for LUAD. TCN1 [haptocorrin or vitamin B12 (cobalamin) R binder], is one of the three transport proteins that binds vitamin B12 and is present in human serum and various biological uids [4]. It plays multiple roles in keeping the basic functions of cell metabolism and proliferation, particularly in haematopoiesis and neural development [5].…”

Section: Introductionmentioning

confidence: 99%

TCN1 is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Lung Adenocarcinoma

Guo

Cai

2021

Preprint

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Background: Around the world Lung cancer is the leading cause of cancer-related death. Lung adenocarcinomas are among the most common diagnosed forms of lung cancer, whose overall survival has not improved significantly, which makes finding an effective therapeutic target vital. Transcobalamin (TCN1) is a vitamin B12 binding protein which regulates cobalamin homeostasis. In tumor tissues, TCN1 is expressed highly, and its expression is correlated with cancer aggressiveness and poor prognosis according to recent studies and bioinformatic analyses. However, its effect on lung adenocarcinoma (LUAD) is unknown. Methods: We evaluated whether TCN1 shows diagnostic and prognostic value in LUAD using bioinformatic analysis. In particularly, various databases and analysis tools were used to determine TCN1’s relationship with LUAD, including TCGA, GTEx, GEO, STRING and TISIDB. Results: As compared to normal lung tissue, the level of TCN1 expression in LUAD tissues was significantly higher. According to univariate Cox statistics, high expression levels of TCN1 correlate with poor OS (overall survival) in LUAD. Moreover, based on a multivariate Cox analysis, TCN1 expression was independently correlated with OS. GO/KEGG and GSEA indicated enrichment in epidermal cell differentiation, keratinocyte differentiation, neuroactive ligand receptor interaction, epithelial mesenchymal transition and TNFA signaling via NFKB. Furthermore, TCN1 is associated with immune infiltration based on an analysis of immune cell infiltration. Conclusions: In summary, TCN1 could be used as a prognostic and diagnostic biomarker and provide deeper perspectives for the development of therapies and prognostic markers in LUAD.

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Serum vitamin B12 and transcobalamin abnormalities in patients with cancer

Carmel

Eisenberg

1977

Cancer

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One hundred and thirty-nine patients with non-hematologic malignancy were studied to define the incidence of vitamin B12-related abnormalities and correlate them with clinical findings. Based on vitamin B12-binding patterns, the following relatively distinct groups were defined: (A) 50% had normal results; (B) 6% had very high transcobalamin (TC) I and vitamin B12 levels as reported in isolated instances previously: most had hepatic metastases and early death, and all had definite metastatic disease; (C) 11% had high vitamin B12 levels with little or no unsaturated TC I elevation: most also had hepatic and other metastases and early death; (D) 23% had high vitamin B12-binding capacity with normal TC I and vitamin B12 levels: there were no distinguishing features for this group other than an increased proportion of black patients; and (E) 10% had low vitamin B12 levels, in many cases not associated with vitamin B12 deficiency or other known causes of low serum levels. Thus, high serum vitamin B12 level, with or without unsaturated TC I elevation, usually implies a poor prognosis in a patient with cancer. However, while most such patients have hepatic and other metastases, hepatic involvement was not universal nor did most patients with hepatic disease have high vitamin B12 levels. High serum TC I thus is not always due to increased granulocytic proliferation or to hepatic tumor, and alternative mechanisms for TC I accumulation should be sought.

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Human plasma R-type vitamin B12-binding proteins. I. Isolation and characterization of transcobalamin I. TRANSCOBALAMIN III. and the normal granulocyte vitamin B12-binding protein.

Cited by 60 publications

References 25 publications

Hypervitaminosis B12 - a new marker and predictor of prognostically unfavorable diseases

Hypervitaminosis B12 - a new marker and predictor of prognostically unfavorable diseases

TCN1 is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Lung Adenocarcinoma

Serum vitamin B12 and transcobalamin abnormalities in patients with cancer

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