Human Plasmodium in Domestic Animals in West Sumba and Fakfak, Indonesia

Munirah, Munirah; Wahyuni, Sitti; Wahid, Isra; Hamid, Firdaus

doi:10.21203/rs.3.rs-98594/v1

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…The current study is a continuation of the findings of h-Plasmodium on previous Etawa goats (1) as an effort to reveal the impasse of information on the role of livestock as hosts for h-Plasmodium. The findings of similar parasites were also reported in livestock populations in Sumba (47). The detected malaria parasites in the trophozoite stage indicated that h-Plasmodium transmission occurred in mammalian livestock groups other than humans.…”

Section: Discussionsupporting

confidence: 81%

Human Plasmodium in Livestock: The Absence of PfHRP2 and pLDH Among High Parasitemia Cases

Sumanto

Hadisaputro

Adi

et al. 2021

Int J Med Parasitol Epidemiol Sci

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Introduction: Plasmodium falciparum and Plasmodium vivax are reported to have infected domestic cattle as buffalo, horses, dogs, and goats in Sumba, along with Etawa crossbreed goats in Purworejo. One of the markers of human-Plasmodium (h-Plasmodium) invasion in the erythrocyte phase is the appearance of PfHRP2 and parasite lactate dehydrogenase (pLDH). This study aimed to detect h-Plasmodium using PfHRP2-pLDH-based rapid diagnostic test (RDT) in the blood of Etawa crossbreed goats that were tested positive for microscopic infection. Methods: A cross-sectional study was conducted in a malaria pre-elimination area in Purworejo District, Indonesia. Livestock blood sampling was performed on a population of goats within a radius of 300 meters from the residence of malaria cases. Results: The presence of h-Plasmodium was detected by Rapid Diagnostic Test (RDT) Monotes Malaria for PfHRP2-pLDH. The mean parasitemia level of h-Plasmodium on Etawa crossbreed goats was 3061 parasites/μL of blood. No cases were detected positive using RDT Monotes Malaria from four goats that were microscopically positive for h-Plasmodium. Conclusion: The PfHRP and pLDH-based RDT methods for the detection of h-Plasmodium indicated that they are not sensitive to be applied to animal blood. Other immunological detection methods are needed to determine the activity of h-Plasmodium when it invades animal red blood cells.

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Section: Discussionsupporting

confidence: 81%

Human Plasmodium in Livestock: The Absence of PfHRP2 and pLDH Among High Parasitemia Cases

Sumanto

Hadisaputro

Adi

et al. 2021

Int J Med Parasitol Epidemiol Sci

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“…Specific research on malaria in goats in Indonesia has not been conducted to date. Parasites resembling human Plasmodium in goats in malaria-endemic areas for humans have been reported in West Sumba, Fakfak (Munirah et al, 2020) and Kaligesing (Sumanto et al, 2021). These reports do not specify the possible blood parasite species found based on an approach to P. caprae since they focus on malaria affecting humans.…”

Section: Introductionmentioning

confidence: 99%

Detection of malaria in goats and sheep

Ratna Nugraheni,

Hari Wardhana,

Awaludin

et al. 2023

J. Ilmu Peternak. Terap.

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Plasmodium species, as the causative agent of malaria, are a significant concern in livestock production. This study aims to investigate the presence of malaria parasites in small ruminants comprised of goats and sheep. Plasmodium infections in ungulates do not cause malaria in humans. However, they might have anopheline mosquitoes as the same vector of this parasite. This study uses molecular techniques, nested PCR, to detect Plasmodium infections in small ruminants, as traditional microscopic examination may lead to misdiagnosis. The results show that Plasmodium infections were found in goat samples from Sumba Barat Daya, Nusa Tenggara Timur, with a prevalence of 7.41% based on nested PCR assay. Notably, Plasmodium was not detected through microscopic examination, underscoring the sensitivity of molecular techniques. It should be noted that none of the goats tested positive for malaria based on microscopic examination, suggesting extremely low parasitemia levels. This study emphasizes the importance of understanding Plasmodium infections in small ruminants, shedding light on their impact on animal health and their potential role in local transmission patterns. The sample size in this study is limited. Further research with larger samples and expanded geographical scope is recommended to comprehensively understand Plasmodium prevalence in small ruminants.

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Human Plasmodium in Domestic Animals in West Sumba and Fakfak, Indonesia

Cited by 2 publications

References 13 publications

Human Plasmodium in Livestock: The Absence of PfHRP2 and pLDH Among High Parasitemia Cases

Human Plasmodium in Livestock: The Absence of PfHRP2 and pLDH Among High Parasitemia Cases

Detection of malaria in goats and sheep

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