Human platelet‐specific antigen frequencies in Indonesian population

Abstract

The development of an HPA-genotyped registry for donors homozygous for HPA-1b, -2b and -6b is desired for the optimum management of PTR patients and children with NAIT.

Human platelet antigen genotyping of platelet donors in southern Brazil

“…Comparison of the HPA frequencies observed in the present study with those reported in Asian (Seo et al ., ; Nie et al ., ; Tan et al ., ; Asmarinah et al ., ), Oceanic (Edinur et al ., ), Amazonian Indians (Castro et al ., ) and Toba Amerindian (De La Vega Elena et al ., ) populations yielded significant differences. These differences may be explained by the negligible participation of these demographic and ethnic groups in the population of Rio Grande do Sul.…”

“…To assess the ability of HPA alleles to describe intercontinental genetic divergence, we conducted an amova , which quantifies separation between populations. Towards this end, we divided the assessed populations into two groups: one comprising the populations of Asia and Oceania, as well as native ethnic groups – Toba Amerindians (De La Vega Elena et al ., ), Parakanã Indians (Castro et al ., ), Native Brazilians, Maori people (Edinur et al ., ), Korea (Pavic et al ., ), Malaysia (Tan et al ., ), Indonesia (Asmarinah et al ., ), China (Nie et al ., ) and Polynesia (Edinur et al ., ) – and one comprising the populations of European and African origin: Poland (Drzewek et al ., ), Denmark (Steffensen et al ., ), Italy (EBI, ), Spain (Muniz‐Diaz et al ., ), the United Kingdom (Jones et al ., ), Slovenia (Rozman et al ., ), Argentina (De La Vega Elena et al ., ), the Congo (Halle et al ., ) and Egypt (Salem et al ., ). Argentina was included in this group because the makeup of its population is strongly European.…”

The importance of platelet antigens and antibodies in immune‐mediated thrombocytopenia

“…Presently, we have a WP also established in Asia, but other continents also need to share this development. n 1a 1b 2a 2b 3a 3b 4a 4b 5a 5b 6a 6b 15a 15b Chinese Han [32] 1000 0Á994 0Á006 0Á951 0Á049 0Á597 0Á406 0Á955 0Á005 0Á986 0Á014 0Á986 0Á014 0Á532 0Á468 Chinese Cantonese [33] 200 0Á995 0Á005 0Á963 0Á037 0Á543 0Á457 0Á995 0Á005 0Á990 0Á010 0Á970 0Á030 0Á403 0Á597 Indonesia [34] 500 0Á970 0Á030 0Á940 0Á060 0Á520 0Á480 0Á950 0Á050 0Á970 0Á030 0Á950 0Á050 0Á510 0Á490 Indonesia [35] 107 0Á991 0Á009 0Á939 0Á061 0Á505 0Á495 1Á000 0Á000 0Á995 0Á005 0Á967 0Á033 --Japan [36] 73 0Á998 0Á020 0Á900 0Á100 0Á718 0Á282 0Á989 0Á011 0Á973 0Á027 0Á973 0Á027 -- [38] 200 0Á988 0Á012 0Á923 0Á077 0Á555 0Á445 0Á990 0Á010 0Á978 0Á022 0Á980 0Á020 --Malaysia [39] 200 0Á975 0Á025 0Á963 0Á037 0Á503 0Á497 0Á995 0Á005 0Á950 0Á050 0Á993 0Á007 0Á515 0Á485 Taiwan [40] 998 0Á995 0Á045 0Á965 0Á035 0Á558 0Á442 0Á997 0Á025 0Á985 0Á015 0Á978 0Á022 0Á537 0Á463 Taiwan [41] 300 0Á997 0Á003 0Á960 0Á040 0Á757 0Á425 0Á998 0Á002 0Á985 0Á015 0Á963 0Á037 0Á538 0Á462 Thai [42] 500 0Á985 0Á015 0Á952 0Á048 0Á560 0Á440 1Á000 0Á000 0Á968 0Á032 0Á986 0Á014 0Á491 0Á509 Northern Thai [43] 300 1Á000 0Á057 0Á997 0Á123 0Á780 0Á713 1Á000 0Á000 1Á000 0Á073 1Á000 0Á030 --Vietnam [44] 120 0Á986 0Á014 0Á953 0Á047 0Á486 0Á514 1Á000 0Á000 0Á972 0Á028 0Á986 0Á014 0Á477 0Á523 Turk [45] 117 0Á863 0Á137 0Á868 0Á133 0Á607 0Á393 0Á996 0Á004 0Á893 0Á107 --0Á474 0Á256 Pakistan [46] 593 0Á885 0Á115 0Á920 0Á080 0Á690 0Á310 1Á000 0Á000 0Á900 0Á100 --0Á590 0Á410 Tunisia [47] 116 0Á780 0Á220 0Á860 0Á140 0Á750 0Á250 1Á000 0Á000 0Á800 0Á200 1Á000 0Á000 0Á510 0Á490 UK [48] 134 0Á844 0Á160 0Á925 0Á075 0Á627 0Á373 1Á000 0Á000 0Á914 0Á086 1Á000 0Á000 0Á524 0Á476 Germany [45] 119 0Á798 0Á202 0Á908 0Á092 0Á567 0Á432 1Á000 0Á000 0Á916 0Á084 --0Á517 0Á483 Macedonia [49] 122 0Á865 0Á135 0Á852 0Á148 0Á578 0Á422 --0Á909 0Á091 ----…”

“…Ethnical variabilities of HPA frequency distribution As described above, the HPA systems involved in NAIT vary between Caucasian and Japanese, the HPA-1 system being predominant in the former and the HPA-4 system in the latter. As shown in Table 2 [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49], presently, there are reports on the frequency distribution of HPAs from different Asian countries, and although differences exist, it seems that the HPA-1 system, like in Japan, is not important in the majority of them. On the other hand, the HPA-4 system, which is important in Japan, is also relevant in South Korea and possibly Indonesia (2 contradictory reports), but not in the other countries.…”

Platelet reactive alloantibodies responsible for immune thrombocytopenia in Malay population

“…7,8 Until today, however, no data is available about the frequencies and the clinical relevance of HPA alloantibodies in these countries. In this study, we presented the first data according the frequencies of platelet reactive alloantibodies in Malaysia, which are responsible for FNAIT and PTR.…”