Human Polyomavirus-6 Infecting Lymph Nodes of a Patient With an Angiolymphoid Hyperplasia With Eosinophilia or Kimura Disease

Rascovan, Nicolás; Bouchard, Sonia Monteil; Grob, Jean-Jacques; Collet-Villette, A.-M.; Gaudy‐Marqueste, C.; Penicaud, Martin; Lépidi, Hubert; Raoult, Didier; Desnues, Christelle

doi:10.1093/cid/ciw135

Cited by 33 publications

(27 citation statements)

References 18 publications

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“…Some recent works have suggested a role of human polyomavirus‐6 in the pathogenesis of ALHE and Kimura disease . However, a recent thorough investigation of polyomaviruses in CLL concluded that there is no association with any of the many viruses tested and this type of leukemia …”

Section: Discussionmentioning

confidence: 99%

“…35 Some recent works have suggested a role of human polyomavirus-6 in the pathogenesis of ALHE and Kimura disease. 39 However, a recent thorough investigation of polyomaviruses in CLL FIGURE 6 Case 3 showed a centrally ulcerated lesion with granulation tissue underneath, as well as features of lichen simplex chronicus in the adjacent epidermis (A). In the dermis, there was a vascular proliferation arranged in nodules intermingled with prominent inflammatory infiltrate (B).…”

Section: Discussionmentioning

confidence: 99%

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Three unusual histopathological presentations of angiolymphoid hyperplasia with eosinophilia

Fernández-Flores

2017

J Cutan Pathol

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Angiolymphoid hyperplasia with eosinophilia (ALHE) is a poorly understood benign vasculoproliferative disorder. Histopathologically, the lesions are composed of a dermal or subcutaneous proliferation of blood vessels of varying sizes with plump and bland endothelial cells, which often show vacuolization and protrusion of the cytoplasm into the lumen. The vascular proliferation is admixed with a diffuse inflammatory infiltrate composed of lymphocytes, eosinophils and mast cells. Lymphoid follicles with germinal centers can sometimes be seen. In addition, fibrosis is a common accompanying feature. Some clinical and histopathological variants of ALHE have already been described in the literature. In this report, we present 3 rare associations of ALHE that have not been previously described. Case 1 was a 73-year-old woman with a lesion on her right medial thigh. Examination showed ALHE admixed with a chronic lymphocytic leukemic (CLL) infiltrate. Case 2 was a 55-year-old woman with a lesion on her right anterior ankle, which was a syringocystadenoma papilliferum co-existing with an ALHE. Case 3 was a 54-year-old man with a lesion on the left medial thigh, which showed overlapping features of IgG4-related disease associated with areas of ALHE. Given these multiple and diverse associations, it seems likely that ALHE may be a reactive rather than neoplastic process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Three unusual histopathological presentations of angiolymphoid hyperplasia with eosinophilia

Fernández-Flores

2017

J Cutan Pathol

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“…Compared to healthy, control, skin samples, viral loads in lesional skin samples are several orders of magnitude higher (w1.44e2.37 Â 10 6 copies/LINE repeat vs. w3.11 Â 10 1 copies/LINE repeat for HPyV6, w2.90 Â 10 3 copies/LINE repeat vs. w1.43 Â 10 1 copies/LINE repeat for HPyV7; 7.28e32.27 Â 10 2 copies/cell vs. 0e0.4 copies/cell for HPyV7) (Nguyen et al, 2017;Ho et al, 2015). HPyV6 has been linked to keratoacanthomas, BRAF inhibitoreassociated epithelial neoplasms, and Kimura disease (Beckervordersandforth et al, 2016;Rascovan et al, 2016;Schrama et al, 2014). However, other research has refuted the link between HPyV6/HPyV7 and other skin diseases, including both neoplastic and inflammatory skin diseases (Bergallo et al, 2018;Fava et al, 2016;Frouin et al, 2014;Haeggblom et al, 2017;Schrama et al, 2012;Scola et al, 2012).…”

Section: Human Polyomaviruses 6 Andmentioning

confidence: 99%

The Biology and Clinical Features of Cutaneous Polyomaviruses

Nguyen

Chamseddin

Cockerell

et al. 2019

Journal of Investigative Dermatology

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Human polyomaviruses are double-stand DNA viruses with a conserved genomic structure, yet they present with diverse tissue tropisms and disease presentations. Merkel cell polyomavirus, trichodysplasia spinulosa polyomavirus, human polyomavirus 6 and 7, and Malawi polyomavirus are shed from the skin, and Merkel cell polyomavirus, trichodysplasia spinulosa polyomavirus, human polyomavirus 6 and 7 have been linked to specific skin diseases. We present an update on the genomic and clinical features of these cutaneous polyomaviruses.

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“…HPVy7 has been associated with a pruritic rash in two lung transplant recipients . HPyV6 has been linked to Kimura disease, a chronic inflammatory disorder with subcutaneous nodules that is endemic in East Asia . Phylogenetic analysis performed on the LT gene sequences revealed the presence of two distinct clades.…”

Section: Phylogeny Of Human Polyomavirusesmentioning

confidence: 99%

“…208 HPyV6 has been linked to Kimura disease, a chronic inflammatory disorder with subcutaneous nodules that is endemic in East Asia. 209 the orangutan polyomaviruses. These discordant phylogenetic relationships suggest that MWPyV is probably derived from an ancestral recombination event.…”

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confidence: 99%

The phylogenetic approach for viral infectious disease evolution and epidemiology: An updating review

Ciccozzi

Lai

Zehender

et al. 2019

Journal of Medical Virology

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In the last decade, the phylogenetic approach is recurrent in molecular evolutionary analysis. On 12 May, 2019, about 2 296 213 papers are found, but typing “phylogeny” or “epidemiology AND phylogeny” only 199 804 and 20 133 are retrieved, respectively. Molecular epidemiology in infectious diseases is widely used to define the source of infection as so as the ancestral relationships of individuals sampled from a population. Coalescent theory and phylogeographic analysis have had scientific application in several, recent pandemic events, and nosocomial outbreaks. Hepatitis viruses and immunodeficiency virus (human immunodeficiency virus) have been largely studied. Phylogenetic analysis has been recently applied on Polyomaviruses so as in the more recent outbreaks due to different arboviruses type as Zika and chikungunya viruses discovering the source of infection and the geographic spread. Data on sequences isolated by the microorganism are essential to apply the phylogenetic tools and research in the field of infectious disease phylodinamics is growing up. There is the need to apply molecular phylogenetic and evolutionary methods in areas out of infectious diseases, as translational genomics and personalized medicine. Lastly, the application of these tools in vaccine strategy so as in antibiotic and antiviral researchers are encouraged.

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Human Polyomavirus-6 Infecting Lymph Nodes of a Patient With an Angiolymphoid Hyperplasia With Eosinophilia or Kimura Disease

Cited by 33 publications

References 18 publications

Three unusual histopathological presentations of angiolymphoid hyperplasia with eosinophilia

Three unusual histopathological presentations of angiolymphoid hyperplasia with eosinophilia

The Biology and Clinical Features of Cutaneous Polyomaviruses

The phylogenetic approach for viral infectious disease evolution and epidemiology: An updating review

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