Human Polyomavirus BK (BKV) Reactivation Among Bulgarian Renal-Allograft Patients

Slavov, Svetoslav Nanev; Kalvatchev, Z.; Simeonov, P; Mladenov, D; Tsvetkov, Mitko; Hristova, L; Kotsev, J.

doi:10.1309/vmn4l9gjt6rcua21

Cited by 2 publications

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References 32 publications

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“…According to the literature, among kidney allograft recipients silent BK viuria may range from 10% to 68%, but not all of them go on to develop NP [5,6]. Older patients showed BKV viremia more than the younger ones, which agrees with a study done by Zhong et al [7] who found that the rate of BK viremia was relatively low in subjects aged <30 years but gradually increased with age in subjects aged !30 years.…”

Section: Discussionsupporting

confidence: 82%

Prevalence of Polyomavirus Among United Arab Emirates Kidney Transplant Recipients: Results From a Single Center

Boobes

Bernieh

Hussain

et al. 2015

Transplantation Proceedings

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Section: Discussionsupporting

confidence: 82%

Prevalence of Polyomavirus Among United Arab Emirates Kidney Transplant Recipients: Results From a Single Center

Boobes

Bernieh

Hussain

et al. 2015

Transplantation Proceedings

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“…The reactivation and replication of Polyomavirus hominis 1 (BK virus, BKV) among renal-transplant recipients could lead to BK-associated nephropathy [Slavov et al, 2008]. The progression of the disease causes post-transplant complications, the most severe of which is allograft rejection [Hirsch and Steiger, 2003].…”

Section: Introductionmentioning

confidence: 99%

Sequence variations of the VP1 gene of Polyomavirus hominis 1 among Bulgarians

Slavov

Tsekov

Kalvatchev

2009

Journal of Medical Virology

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Polyomavirus hominis 1 (BK virus, BKV) is an important pathogen in the field of transplantation medicine. BKV reactivation among renal-transplant recipients could cause BK associated nephropathy, which has unfavorable prognosis and is a cause for graft rejection. It is not clear why only few transplanted patients develop BK associated nephropathy while most exhibit asymptomatic viruria. One of the possible reasons lies in the mutations of the VP1 gene, encoding the main structural protein, bearing important determinants for the recognition of specific cellular receptors. The change of amino acid sequence could result in altered pathogenicity of BKV. The amplified sequences of BK in this research were from urines of patients with various clinical conditions along with healthy individuals. Nevertheless the sequence analysis which was undertaken did not show correlation between the viral genotype and the clinical condition. It was demonstrated that the most common BKV genotype in Bulgaria is genotype I and that the strains common in Bulgaria (genotypes I and IV) have typical European origin. Most of the sequenced BKV DNA samples (8/10) were correlated with the highest degree of similarity (81%) to the subcluster Ib. A specific place among the samples is taken by Pr-9, amplified from the urine of a pregnant woman that has a different evolutionary origins and might establish the beginning of a new distinct BKV strain.

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Human Polyomavirus BK (BKV) Reactivation Among Bulgarian Renal-Allograft Patients

Cited by 2 publications

References 32 publications

Prevalence of Polyomavirus Among United Arab Emirates Kidney Transplant Recipients: Results From a Single Center

Prevalence of Polyomavirus Among United Arab Emirates Kidney Transplant Recipients: Results From a Single Center

Sequence variations of the VP1 gene of Polyomavirus hominis 1 among Bulgarians

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