Human Primary Auditory Cortex: Cytoarchitectonic Subdivisions and Mapping into a Spatial Reference System

Morosan, Patricia; Rademacher, J.; Schleicher, Axel; Amunts, Katrin; Schormann, Thorsten; Zilles, Karl

doi:10.1006/nimg.2000.0715

Cited by 716 publications

(686 citation statements)

References 95 publications

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“…These regions are not likely to contain significant portions of primary auditory cortex (Morosan et al, 2001, Rademacher et al, 1993. While some regions of secondary, or belt, auditory cortex exhibit frequency tuning, tuning is often more complex or less specific in these regions (i.e., preference for broadband rather than pure tone stimuli (Kosaki et al, 1997)).…”

Section: Discussionmentioning

confidence: 99%

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Rojas

Slason

Teale

et al. 2007

Schizophrenia Research

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Deficits in basic auditory perception have been described in schizophrenia. Previous electrophysiological imaging research has documented a structure-function disassociation in the auditory system and altered tonotopic mapping in schizophrenia. The present study examined auditory cortical tuning in patients with schizophrenia.Eighteen patients with schizophrenia and 15 comparison subjects were recorded in a magnetoencephalographic (MEG) experiment of auditory tuning. Auditory cortical tuning at 1 kHz was examined by delivering 1 kHz pure tones in conjunction with pure tones at 5 frequencies surrounding and including 1 kHz. Source reconstruction data were examined for evidence of frequency specificity for the M100 component.There was a significant broadening of tuning in the schizophrenia group evident for the source amplitude of the M100. The frequently reported reduction in anterior-posterior source asymmetry for individuals with schizophrenia was replicated in this experiment. No relationships between symptom severity ratings and MEG measures were observed.This finding suggests that the frequency specificity of the M100 auditory evoked field is disturbed in schizophrenia, and may help explain the relatively poor behavioral performance of schizophrenia patients on simple frequency discrimination tasks. KeywordsMagnetoencephalography; Evoked Potentials; Auditory Cortex; Mental Illness; N100; M100 Corresponding Author: Donald C. Rojas, Ph.D. Box C268−68 CPH Rm 2J10 4200 E. 9th Avenue Denver, CO 80262 Phone: (303) 315 −8624 FAX: (303) 315−5641 email: Don.Rojas@uchsc.edu. Contributors D.C.R designed the study, performed the statistical analysis and wrote the manuscript. E.S. contributed data analyses and preliminary statistical analyses. P.D.T. contributed to the design of the experiment and selection of data analytic strategies and M.L.R. had substantial input on clinical aspects of the design, including selection and implementation of schizophrenia diagnostic and clinical measures appearing in the paper. All authors have contributed to and approved the final manuscript.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of InterestAll authors declare that they have no conflicts of interest with respect to this manuscript. NIH Public Access IntroductionThe M100 auditory evoked field has been reported to show anomalous anterior-posteior source location asymmetry in actively psychotic patients with paranoid schizophrenia. In normal adults, the neuroanatomical source of the M100 component is further anterior in the right hemisphere (Baumann et al., 1991). We and ...

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Section: Discussionmentioning

confidence: 99%

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Rojas

Slason

Teale

et al. 2007

Schizophrenia Research

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“…Interactions between the auditory What and Where streams are likely to occur on the supratemporal plane, where the two streams partially overlap (Altmann et al, 2007;Arnott et al, 2004;Griffiths and Warren, 2002;Hart et al, 2004;Hunter et al, 2003;Viceic et al, 2006). Several architectonically defined areas are located within this region, including the primary (on Heschl's gyrus; Morosan et al, 2001) and several non-primary auditory areas: the anterior (AA), anterolateral (ALA), lateral (LA), medial (MA), posterior (PA), and superior temporal (STA) areas (as identified by their histo-and immunohistochemical characteristics; Rivier and Clarke, 1997;Wallace et al, 2002). The diversity of the early-stage non-primary areas may reflect functional specialisation, such as proposed for speech processing in LA and STA (Scott and Johnsrude, 2003).…”

Section: Introductionmentioning

confidence: 99%

Where sound position influences sound object representations: A 7-T fMRI study

et al. 2011

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“…3. Comparing cytoarchitectonic probability maps generated using the proposed method and the previously published maps [8], superimposed on Colin27 brain assigned high probabilities by both maps, the maps do not segregate the regions well. We evaluate the two methods for such between-map overlap (i.e., Te1.0/Te1.1, Te1.0/Te1.2, and Te1.1/Te1.2).…”

Section: Evaluation Frameworkmentioning

confidence: 77%

“…A list of available maps is given in [7]. In primary auditory cortex, Morosan and colleagues [8] developed maps of three subregions: Te1.0, Te1.1, and Te1.2, which all overlap with the anteriormost gyrus of Heschl (HG). Figure 1 shows the cross-sectional views for a post-mortem brain with the corresponding cytoarchitectonic labels of the three subregions.…”

Section: Introductionmentioning

confidence: 99%

A New Approach for Creating Customizable Cytoarchitectonic Probabilistic Maps without a Template

Tahmasebi

Abolmaesumi

Geng

et al. 2009

Lecture Notes in Computer Science

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Abstract. We present a novel technique for creating template-free probabilistic maps of the cytoarchitectonic areas using a groupwise registration. We use the technique to transform 10 human post-mortem structural MR data sets, together with their corresponding cytoarchitectonic information, to a common space. We have targeted the cytoarchitectonically defined subregions of the primary auditory cortex. Thanks to the templatefree groupwise registration, the created maps are not macroanatomically biased towards a specific geometry/topology. The advantage of the groupwise versus pairwise registration in avoiding such anatomical bias is better revealed in studies with small number of subjects and a high degree of variability among the individuals such as the post-mortem data. A leave-oneout cross-validation method was used to compare the sensitivity, specificity and positive predictive value of the proposed and published maps. We observe a significant improvement in localization of cytoarchitectonically defined subregions in primary auditory cortex using the proposed maps. The proposed maps can be tailored to any subject space by registering the subject image to the average of the groupwise-registered post-mortem images.

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Human Primary Auditory Cortex: Cytoarchitectonic Subdivisions and Mapping into a Spatial Reference System

Cited by 716 publications

References 95 publications

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Where sound position influences sound object representations: A 7-T fMRI study

A New Approach for Creating Customizable Cytoarchitectonic Probabilistic Maps without a Template

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