Human Puumala and Dobrava Hantavirus Infections in the Black Sea Region of Turkey: A Cross-Sectional Study

Gözalan, Ayşegül; Kalaycioglu, Handan; Uyar, Yavuz; Sevindi, Demet Furkan; Turkyilmaz, Bedia; Çakir, Vedat; Cindemir, Cengiz; Unal, Belgin; Yağcı-Çağlayık, Dilek; Korukluoğlu, Gülay; Ertek, Mustafa; Heyman, Paul; Lundkvist, Åke

doi:10.1089/vbz.2011.0939

Cited by 18 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dobrava virus (DOBV) is also associated with HFRS syndrome, for which men are accidental hosts 65 . Mortality rates vary according to the genotype, ranging from 0.5% (DOBV -Kurkino) to 12% (DOBV -Dobrava and DOBV -Sochi) 66,67 .…”

Section: Hantavirus (Hv)mentioning

confidence: 99%

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

This review focuses on reports of hepatitis E virus, hantavirus, rotavirus, coronavirus, and arenavirus in synanthropic rodents (Rattus rattus, Rattus norvegicus, and Mus musculus) within urban environments. Despite their potential impact on human health, relatively few studies have addressed the monitoring of these viruses in rodents. Comprehensive control and preventive activities should include actions such as the elimination or reduction of rat and mouse populations, sanitary education, reduction of shelters for the animals, and restriction of the access of rodents to residences, water, and food supplies.

show abstract

Section: Hantavirus (Hv)mentioning

confidence: 99%

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…In the current outbreak, dealing with rodent control activities in gardens or in annexes of the house and being male were found to be significant risk factors for human hantavirus infection. In two seroprevalence studies—one performed at the outbreak area and the other at the Giresun Province situated at the Eastern part of the Black Sea Region—being male, the presence of a barn near one's house, living in the woods or an adobe house and working in a forest were found to be statistically significant risk factors for hantavirus infection (Gozalan et al, ; Sevencan et al, ).…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Çelebi

Öztoprak

Öktem

et al. 2019

Zoonoses and Public Health

Self Cite

View full text Add to dashboard Cite

Background Some of the hantavirus species in Euro‐Asia cause haemorrhagic fever with renal syndrome (HFRS) in humans. The first documented human hantavirus infection in Turkey was diagnosed in 2009. This report describes the dynamics of the first hantavirus outbreak that emerged in humans in the Western Black Sea Region of Turkey. Methods All the suspected cases of hantavirus infection were admitted to the Infectious Diseases and Clinical Microbiology Department at the Zonguldak Bülent Ecevit University Hospital in Zonguldak, Turkey. The patients were carefully interviewed, examined and evaluated using routine laboratory tests and hantavirus diagnostic tools. Hantavirus‐reactive antibodies (IgM and IgG) in serum samples were detected via enzyme immune assay (EIA) and immunofluorescence assay (IFA) in the acute and convalescence stages of the disease. The presence of hantavirus ribonucleic acid (RNA) was analysed via reverse transcription polymerase chain reaction (RT‐PCR) in serum and urine samples. A focus reduction neutralization test (FRNT) was performed to confirm specific hantavirus serotypes. In addition, a case–control study was conducted to identify possible risk factors for hantavirus transmission in the outbreak area. A control group was composed of asymptomatic individuals who were seronegative for hantavirus IgM and IgG and living in the outbreak area. Results A total of 55 suspected cases of hantavirus infection were admitted to the inpatient clinic between February and June of 2009. Twenty‐four patients were diagnosed with acute HFRS via EIA or IFA. In 22 of the 24 infected patients, Puumala virus (PUUV) was identified as the causative hantavirus type by detecting IgM in the acute stage and an increase in the IgG level in follow‐up serum samples. PUUV was also verified as the infecting agent by FRNT in two of the 24 cases. Among the 24 laboratory‐confirmed HFRS cases, 21 (87.5%) were males and 3 (12.5%) were females, and the mean age was 45.92 years (standard deviation ± 16.90 years). Almost all these individuals were living in villages or rural areas. The 24 HFRS cases were matched with 26 healthy controls for statistical analyses and according to binary logistic regression analysis, and dealing with rodent control activities in gardens or in annexes of their homes (p = 0.021 and Odds ratio [OR] = 17.11) and being male (p = 0.019 and OR = 22.37) were detected as statistically significant risk factors for hantavirus infection. The most commonly observed clinical complaints were fatigue (95.8%), shivering (91.7%), fever (87.1%), headache (70.8%) and nausea (70.8%). Haemodialysis was required for four patients (16.7%). Except for the first case diagnosed with acute hantavirus infection, no patient died. The mean delay time to hospital admission from initiation of symptoms was 5.3 days, the mean duration of febrile days was 2.6 days, and the mean duration of hospital stay was 8.5 days. Conclusion Hantaviruses are circulating in Turkey and causing sporadic or epidemic infection in humans. Addit...

show abstract

“…The first HFRS cases were reported from the Western Black Sea Region in 2009 . Follow‐up studies described more hantavirus infections in rodents and suspicious HFRS cases in humans in different regions of Turkey . Several rodent hosts have been identified to carry hantaviruses, namely Apodemus flavicollis (Dobrava‐Belgrade virus [DOBV]) , Myodes glareolus (Puumala virus [PUUV]) , Apodemus agrarius (Saaremaa virus [SAAV]) , Microtus arvalis (Tula virus [TULV]), and Rattus norvegicus (Seoul virus [SEOV]); these rodent species are all found in Turkey …”

Section: Introductionmentioning

confidence: 99%

Dobrava hantavirus variants found in Apodemus flavicollis mice in Kırklareli Province, Turkey

Polat

Sironen²,

Plyusnina³

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

Hantaviruses infect humans via inhalation of viral particles within secretions of infected rodents or rarely through direct contact with infected rodents. Determining the prevalence of hantavirus infections among rodent populations is of vital importance to obtain information on hantavirus-related cases and to predict possible outbreaks. We hypothesized that DOBV strains circulating in the Thrace Region in Turkey would be related to other Balkan DOBV strains. In this study, hantavirus infections in the rodent population of the Kırklareli-İğneada Region (north-western Turkey, near the Bulgarian border) were investigated. This region is of particular importance, as it is located in the south-eastern margin of the European continent and was used as an entrance point of Asian faunal elements into Europe. DOBV infection was detected in eight of 73 rodents; all were of the Apodemus flavicollis species. Partial sequences of the viral S-, M-, and L-genome segments were recovered and compared with previously reported DOBV sequences. The newly characterized Turkish strains were similar to other DOBV variants. Silent nucleotide mutations were dominant. The hantavirus prevalence in the İğneada region was similar to what has been reported in Greece and Bulgaria. For the first time, the M-segment sequences of DOBV from Turkey were recovered and genetic data of hantaviruses from Thrace region of Turkey were obtained.

show abstract

Human Puumala and Dobrava Hantavirus Infections in the Black Sea Region of Turkey: A Cross-Sectional Study

Cited by 18 publications

References 25 publications

Synanthropic rodents as virus reservoirs and transmitters

Synanthropic rodents as virus reservoirs and transmitters

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Dobrava hantavirus variants found in Apodemus flavicollis mice in Kırklareli Province, Turkey

Contact Info

Product

Resources

About