2018
DOI: 10.1016/j.jbmt.2018.09.049
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Human recombinant hyaluronidase injections for upper limb muscle stiffness in individuals with cerebral injury: A case series

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Cited by 6 publications
(12 citation statements)
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“…The observation of increased corneal stromal stiffness following HAse injection in normal rabbit contrasts with a recent clinical study whereby injection of HAse reduced the stiffness of muscle tissue in patients with upper limb spasticity. 29 Muscle stiffness in spasticity is defined by resistance of muscle to passive movement and is a disorder in individuals affected by neurologic injury of cerebral and spinal origin. 29 Furthermore, our data also call into question the widely held belief that HAse softens tissues to reduce scarring and increases drug penetration.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The observation of increased corneal stromal stiffness following HAse injection in normal rabbit contrasts with a recent clinical study whereby injection of HAse reduced the stiffness of muscle tissue in patients with upper limb spasticity. 29 Muscle stiffness in spasticity is defined by resistance of muscle to passive movement and is a disorder in individuals affected by neurologic injury of cerebral and spinal origin. 29 Furthermore, our data also call into question the widely held belief that HAse softens tissues to reduce scarring and increases drug penetration.…”
Section: Discussionmentioning
confidence: 99%
“…29 Muscle stiffness in spasticity is defined by resistance of muscle to passive movement and is a disorder in individuals affected by neurologic injury of cerebral and spinal origin. 29 Furthermore, our data also call into question the widely held belief that HAse softens tissues to reduce scarring and increases drug penetration. 15,16,30 These observations suggest that the function of HAse may be tissue and disease specific as well as dependent on the endogenous amount of HA and other GAG substrates expressed in the tissue.…”
Section: Discussionmentioning
confidence: 99%
“…Subjects with stroke were assessed on clinical metrics which included measurement of upper limb motor impairment using the Fugl-Meyer Scale (FMS), 22 strength testing using the Manual Muscle Test (MMT), 23 active range of motion (AROM) measured by video motion analysis using Dartfish, 24-26 and muscle stiffness or the resistance to passive joint movement measured using the Modified Ashworth Scale (MAS). 27…”
Section: Methodsmentioning
confidence: 99%
“…Studies in animal models of contracture have provided evidence that hyaluronan accumulation in the ECM may alter the viscoelastic properties of muscle, contributing to contracture . Results were presented from a preliminary study of treatment with intramuscular hyaluronidase, an enzyme that degrades ECM hyaluronan in patients with upper limb muscle stiffness and spasticity after cerebral injury who were at risk of developing contractures. In this study, researchers demonstrated reduced muscle stiffness and increased passive and active joint movement, which persisted 3 to 5 months after treatment.…”
Section: Therapeutic Strategiesmentioning
confidence: 99%