2019
DOI: 10.1016/j.tracli.2018.08.001
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Human red blood cell polymorphisms prevalent in Colombian population and its protective role against malaria

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“…For example, it is widely known that sickle‐cell anemia confers resistance to malaria. Therefore, suppression of sickle‐cell anemia through gene editing can increase susceptibility to malaria (Jajosky, Jajosky, and Jajosky 2018; Contreras and Alviz 2019). Given the complexity of genetic networks, it is difficult and often impossible to predict all the consequences of altering even a single gene in that network.…”
Section: Science Of Crisprmentioning
confidence: 99%
“…For example, it is widely known that sickle‐cell anemia confers resistance to malaria. Therefore, suppression of sickle‐cell anemia through gene editing can increase susceptibility to malaria (Jajosky, Jajosky, and Jajosky 2018; Contreras and Alviz 2019). Given the complexity of genetic networks, it is difficult and often impossible to predict all the consequences of altering even a single gene in that network.…”
Section: Science Of Crisprmentioning
confidence: 99%