Human regional lymph nodes draining cancer exhibit a profound dendritic cell depletion as comparing to those from patients without malignancies

Laguens, Graciela; Coronato, Silvia; Laguens, Rubén P.; Portiansky, Enrique Leo; Girolamo, V Di

doi:10.1016/s0165-2478(02)00172-4

Cited by 30 publications

(20 citation statements)

References 13 publications

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“…Decreased DC density in the SN and a decrease in the area of the SN paracortex occupied by DC has been reported in studies of different solid tumors [33], especially melanoma and breast cancer [34][35][36][37]. This alteration was observed in DC expressing S100 protein, CD1a, fascin, MHC-class II, CD40, CD80, CD83 CD86, Langrin and DC-lamp.…”

Section: Paracortical Dendritic Cellsmentioning

confidence: 51%

Experimental frontiers for clinical applications: Novel approaches to understanding mechanisms of lymph Node metastases in melanoma

Essner

2006

Cancer Metastasis Rev

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Sentinel lymph nodes are the first nodes to receive lymph from primary tumors and are the preferential site of initial metastases. Sentinel nodes show morphology changes that suggests immune modulation with reduced antigen-presenting dendritic cells, activated T lymphocytes, high endothelial venules and transvenular migration of T lymphocytes. Tumor cells generate down-regulatory molecules. We postulate that tumor-induced immune dysfunction facilitates establishment of nodal metastases. Nodal immune modulation can be reversed by granulocyte macrophage colony-stimulating factor (GMCSF), a finding with implications for future therapy to prevent or reverse these nodal metastases.

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Section: Paracortical Dendritic Cellsmentioning

confidence: 51%

Experimental frontiers for clinical applications: Novel approaches to understanding mechanisms of lymph Node metastases in melanoma

Essner

2006

Cancer Metastasis Rev

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“…Chemotaxins expressed constitutively by tumors allow recruitment and polarization of multiple immune cell types to assist in migration and vascular/ lymphatic invasion [25,26]. Dendritic cells may be depleted or blocked at an immature stage both at the tumor site and in regional lymph nodes, resulting in impairment of antigen presentation, costimulation, and migratory responses [27][28][29]. Kohrt et al [30] noted that regional lymph node immune profiles in patients with breast cancer changed independent of nodal metastases and concluded that impairment of the immune response is likely a critical step in lymph node invasion by tumor and may precede microscopic metastasis detection.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidal reactions in regional lymph nodes of patients with early stage non–small cell lung cancer predict improved disease-free survival: a pilot case-control study

et al. 2012

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“…10 One of the requirements for glycolipids to be efficient immunogens is the maintenance of the antigen-bearing molecules for a sufficient time to allow T-cell recognition. In vitro data suggest that the half-life of CD1-antigen complexes is 24 h, which is adequate for T-cell stimulation.…”

Section: Discussionmentioning

confidence: 99%

CD1a down‐regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome

et al. 2007

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CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome Aims: CD1a is a molecule belonging to the highly conserved group of CD1 proteins. Its expression in dendritic cells is related to the presentation of tumourderived glycolipid antigens to T cells and, consequently, the development of a successful antitumour response. The aim was to investigate the presence of CD1a+ cells in both primary tumours and lymph nodes (LN) of a series of 35 invasive ductal carcinomas by both immunohistochemistry and reverse transcription-polymerase chain reaction. Methods and results: CD1a antigen was more expressed in N0 than N1 breast cancer (P < 0.0001) in both primary lesions and LN metastases and correlated positively and significantly with oestrogen (ER) (P = 0.0025) and progesterone (P = 0.0226) receptor (PR) status, as well as CD4+ and CD8+ T-lymphocyte infiltration. Conclusions: This is the first report to show a link between CD1a+ mononuclear cells in breast cancer and in paired LN metastases. The positive and significant correlations between the number of CD1a+ cells and positivity of the primary tumour for ER and PR suggest a possible role for CD1a as a prognostic marker for breast cancer, raising the possibility that hormone receptor-positive breast cancer patients may have a better prognosis in the presence of greater dendritic cell infiltration.

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Human regional lymph nodes draining cancer exhibit a profound dendritic cell depletion as comparing to those from patients without malignancies

Cited by 30 publications

References 13 publications

Experimental frontiers for clinical applications: Novel approaches to understanding mechanisms of lymph Node metastases in melanoma

Experimental frontiers for clinical applications: Novel approaches to understanding mechanisms of lymph Node metastases in melanoma

Sarcoidal reactions in regional lymph nodes of patients with early stage non–small cell lung cancer predict improved disease-free survival: a pilot case-control study

CD1a down‐regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome

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