Human Rhinovirus Infection in Children with Cystic Fibrosis

Esposito, Susanna; Daccò, Valeria; Daleno, Cristina; Gambazza, Simone; Montinaro, Valentina; Bisogno, Arianna; Principi, Nicola; Colombo, Carla

doi:10.7883/yoken.67.399

Cited by 14 publications

(15 citation statements)

References 15 publications

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“…Esposito et al showed that human rhinovirus is the most commonly associated viral infection with CF patients. Rhinovirus detection was significantly associated with the occurrence of CF pulmonary exacerbation [18].…”

Section: Discussionmentioning

confidence: 97%

The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia

Banjar

Chaballout

Karkour

et al. 2020

International Journal of Pediatrics and Adolescent Medicine

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Introduction: Studies have shown that pulmonary exacerbations in cystic fibrosis (CF) patients are associated with respiratory viruses. The most common agent causing viral infections in patients with CF before the age of 3 years is respiratory syncytial virus. Objectives: To obtain the prevalence of the different types of viral infection in CF patients and to identify its relation with the type of bacterial infection, (CFTR) mutations and pulmonary function test (PFT). Methodology: A retrospective charts review of 387 patients with CF of all age groups who were screened for the detection of viruses during respiratory exacerbation from the period of January 1,1984 to June 1, 2016. Results: A total of 159 CF patients had pulmonary exacerbation and had viral PCR obtained. Fifty-eight patients (36%) had positive viral PCR. Males were more commonly infected in 30/58 patients (52%) compared to females in 28 patients (48%). Forty-five of 58 patients (78%) were alive and 13 patients (22%) died. Rhinovirus was the most frequently reported viral PCR in 33/74 sample (45%). Out of 74 viral PCR, 41 (55.4%) were during the colder seasons (October–February) and 33 (44.5%) during the warmer seasons (March–September). During viral infection and viral recurrence, there was an increase in bacterial colonization specifically of H. influenza and staphylococcus aureus. The most common CFTR mutation for the CF viral infection is: 3120+1G>A in Intron 16 in 11/57 patients (19%). The Eastern Province had the highest viral infection of 24 out of 57 patients (42%). Follow-up PFT post viral infection showed no significant difference in the type and the severity of PFT compared to the initial PFT during the viral illness. Conclusion: Viral infections contributed to the increase in morbidity and mortality of CF patients in our population, and rhinovirus was the most common causative agent. Viral infections and viral recurrence increased the prevalence of bacterial infection of specific pathogens such as H. in fluenza and S. aureus. Physicians should be aware to prevent progressive lung damage in CF patients by treating the concomitant viral and bacterial infections. Viral infection may be associated with some common CFTR mutations.

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Section: Discussionmentioning

confidence: 97%

The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia

Banjar

Chaballout

Karkour

et al. 2020

International Journal of Pediatrics and Adolescent Medicine

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“…A study by de Almeida and colleagues reported a significant association between RV‐A2 or −C and respiratory exacerbations in children with cystic fibrosis (CF) . We, and others, have previously reported that RV was the most common respiratory virus detected in a cohort of children with CF during their regular clinic visits, however RV was not significantly associated with respiratory exacerbations in these studies . Understanding the impact of respiratory viral infections in children with CF is important in managing and minimising the progression of their disease.…”

Section: Introductionmentioning

confidence: 82%

Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data

Stelzer-Braid

Liu

Doumit

et al. 2017

Journal of Medical Virology

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Rhinovirus (RV) is a common respiratory viral infection linked to worsening of chronic respiratory diseases including cystic fibrosis (CF) and asthma. RV was tested by RT-PCR in samples (n = 465) collected from the upper (nasal swab, oropharyngeal suction, and sputum) and lower (bronchoalveolar washings) respiratory tract of 110 children with CF. Air samples (n = 52) collected from the operating theatres and outpatient clinics were tested for RV. RV was found in 43% of children <5 years suffering an exacerbation, and 12% of older children (5-17 years). RV particles were detected in the air of clinic rooms. Detection of RV is important in better understanding viral infections in patients with CF.

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“…A few studies have used PCR to detect HRV infections in CF patients, but they did not sample during symptom-free episodes or lacked adequate non-CF control groups. [20][21][22][23] Our study adds unique longitudinal data from healthy and diseased children irrespective of complaints, using genotyping of HRV subtypes to distinguish prolonged detection of the same HRV strain from increased infections with different HRV subtypes.…”

Section: Discussionmentioning

confidence: 99%

Frequency and Duration of Rhinovirus Infections in Children With Cystic Fibrosis and Healthy Controls

Dijkema¹,

Ewijk

Wilbrink

et al. 2016

Pediatric Infectious Disease Journal

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Human Rhinovirus Infection in Children with Cystic Fibrosis

Cited by 14 publications

References 15 publications

The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia

The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia

Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data

Frequency and Duration of Rhinovirus Infections in Children With Cystic Fibrosis and Healthy Controls

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