Human Rotavirus G9 and G3 as Major Cause of Diarrhea in Hospitalized Children, Spain

Sánchez-Fauquier, Alicia; Montero, Vanessa; Moreno, Sílvia; Solé, Monica; Colomina, Javier; Iturriza‐Gómara, Miren; Revilla, Ana; Wilhelmi, Isabel; Gray, Jim

doi:10.3201/eid1210.060384

Cited by 78 publications

(62 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Europe, the new strains were initially detected in the United Kingdom (1995-1996) combined with P-type 6, which was replaced by P-type 8 in the next few years [18] A well-documented finding in this survey was the marked decrease in the current decade in the circulation of the G4 genotype. This genotype circulated widely in our environment in the 1990s but only sporadically after 1999, in line with prior reports in Spain [22] but in contrast with reports from other European regions [2,22,[24][25][26].…”

Section: Discussionsupporting

confidence: 90%

Rotavirus genotypes in children in the Basque Country (northern Spain) over a 13-year period (July 1996–June 2009)

Cilla

Montes

Gomariz

et al. 2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Rotavirus genotypes in children in the Basque Country (northern Spain) over a 13-year period (July 1996–June 2009)

Cilla

Montes

Gomariz

et al. 2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

“…7 It was re por ted that ro ta vi rus was res pon sib le for 11-71% and ade no vi ru ses for 2-22% of vi ral gas tro en te ri tis ca ses in va ri o us co un tri es. 8,9 In the stu di es con duc ted in Tur key, it has been re por ted that ro ta vi rus po si ti vity was bet we en 9.8% and 39.8%, 10,11 and this ra te was 7.8-10% for ade no vi rus po si ti vity. 4 In this study, the se va lu es we re 16.2% (483) and 2.3% (77) for ro ta vi rus and ade no vi rus, res pec ti vely.…”

Section: Discussionmentioning

confidence: 99%

“…22,23 It has be en re por ted pre vi o usly that ro ta vi rus gas tro en te ri tis is most fre qu ent du ring win ter and at the be gin ning of spring whi le ade no vi rus is ob ser ved thro ug ho ut the ye ar. 8,10,14,22 In Tur key, ro ta vi rus is hig hest in Ja nu ary, Ap ril, and Feb ru ary. 19,25,26 Our da ta are si mi lar to pre vi o us re ports.…”

Section: Discussionmentioning

confidence: 99%

Detection of Rotavirus and Enteric Adenovirus Antigens in Outpatients with Gastroenteritis

Rad¹,

Gözalan²

2010

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : One of the most important reasons of mortality, especially in childhood, is infectious diarrheas. As their epidemiology is not well known in Turkey, the aim of this study is to characterize the distribution of gastroenteritis caused by rotavirus and adenovirus by age groups. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Determination of rotavirus and adenovirus antigens in stool samples of 2.962 patients admitted to MESA hospital with the diagnosis of acute gastroenteritis between January 2005 and June 2008 as carried out by the immunochromatographic method. R Re es su ul lt ts s: : 605 of 2.962 stool samples were found to have viral antigens. 483 of those positive samples were found to be positive for rotavirus, and 77 of them were found to be positive for adenovirus. Forty five of the samples tested were positive for both virus antigens. Additionally, rotavirus and adenovirus associated gastroenteritis was observed most frequently in the 0-5 year-old group; and rotavirus was more common during winter, while adenovirus was observed throughout the year. C Co on nc cl lu us si io on n: : In this study, it was shown that rotavirus and adenovirus were more significant causes of gastroenteritis, especially in winter among 0-5-year old group. It must also be stated that rapid and effective diagnostic methods are important to prevent unnecessary antibiotic usage, and to reduce the development of antibacterial resistance.K Ke ey y W Wo or rd ds s: : Rotavirus; adenoviridae; gastroenteritis Ö ÖZ ZE ET T A Am ma aç ç: : Özellikle çocukluk çağında, mortalitenin en önemli nedenlerinden biri enfeksiyöz ishallerdir. Türkiyede epidemiyolojisi iyi bilinmeyen rotavirüs ve adenovirüs etkenlerine bağlı meydana gelen gastroenterit olgularının çeşitli yaş grupları, aylara ve yıllara göre dağılımını belirlemeyi amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Ocak 2005 ve Haziran 2008 tarihleri arasında hastanemizin çeşitli kliniklerine başvuran ve akut gastroenterit tanısı alan 2,962 hastanın dışkı numunelerinde, rotavirüs ve adenovirüs antijenleri immunokromatografik yöntem ile araştırıldı. B Bu ul lg gu ul la ar r: : İkibindokuz yüzaltmışiki dışkı örneğinin 605'inde viral antijenler saptandı. Pozitif örneklerin 483'ü rotavirüs, 77'si adenovirüs yönünden pozitif olarak bulundu. Kırkbeş örnekte her iki virüs için birlikte pozitiflik saptandı. Viral gastroenterit olgularına (rota ve adenovirüs) en sık 0-5 yaş grubunda rastlanmakta olup, rotavirüs daha çok kış aylarında, adenovirüs ise bütün yıl boyunca görülmektedir. S So on nu uç ç: : Bölgemizde özellikle kış aylarında ve 0-5 yaş grubunda gelişen gastroenteritlerde rota ve adenovirüsün önemli bir etken olduğu görülmektedir. Hızlı ve geçerli (yüksek duyarlılık ve özgüllükte) tanı yöntemleri antibiyotik kullanımının önlenmesi ile beraber antibakteriyel direnç gelişiminin azaltılması yönünden önemlidir.

show abstract

“…The literature on rotavirus strains circulating in the European Union has been reviewed, including considerably more information than was gathered in the survey [22]. The predominant strain can shift rapidly, as was recently observed in Spain where the usual G1 P[8] and G4 P[8] strains found between 1997 and 2004 were found to have been supplanted by G(9) P[8] in a 2005 study [23]. Therefore countries considering the introduction of rotavirus vaccination should, at least intermittently, monitor the circulating strains.…”

Section: Rotavirus Strainsmentioning

confidence: 99%

Survey of rotavirus surveillance, laboratory capacity and disease burden in the eastern part of the WHO European Region

Williams

Gray²,

Pebody³

et al. 2008

Eurosurveillance

View full text Add to dashboard Cite

E U ROSU R V E I L L A N C E Vol . 13 · I ssu es 7-9 · J ul -Sep 20 08 · w w w. e urosurve illance. o rg 1 R e s e a r c h a r ti c l e s S u r v e y o f r o tav i r u S S u r v e i l l a n c e , l a b o r at o r y c a p a c i t y a n d d i S e a S e b u r d e n i n t h e e a S t e r n p a r t o f t h e W h o e u r o p e a n r e g i o n C J Williams (christopher.williams@norfolk.nhs.uk) 1,2 , Jim Gray 1 , R G Pebody 1 , A Lobanov 3 1. Health Protection Agency Centre for Infections, London, United Kingdom 2. European Training Programme for Intervention Epidemiology (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden 3. World Health Organization Regional Office for Europe, Copenhagen, Denmark (former staff member)Following the licensure of two rotavirus vaccines in Europe, we aimed to assess factors, such as surveillance, disease burden and laboratory capacity, which will be relevant for making decisions about rotavirus vaccine introduction in the different countries. We conducted an email-based survey of the national public health bodies in the World Health Organization (WHO) European Region in 2006 and report here the results from the 23 countries in the eastern part of the region. The survey included questions on rotavirus surveillance, laboratory capacity, burden (in children under the age of five years) and intention to introduce rotavirus vaccination. Countries were grouped into the four per-capita income categories defined by the World Bank. Fourteen of the 23 countries responded to the survey. All except one country reported that less than a quarter of their laboratories had rotavirus diagnostic capacity. Four countries had some form of specific rotavirus surveillance, but half were of very limited coverage. Ten countries did not report data on the incidence of rotavirus hospital admissions, although nine were able to report some data on rotavirus burden. Six of the responding countries said they were likely to introduce universal rotavirus vaccination. Rotavirus surveillance and laboratory capacity in the eastern part of the WHO European Region is limited but most countries had some estimate of rotavirus burden, often from special studies. The reported mortality rates were lower than those from a WHO mortality data source. Many countries in the eastern part of WHO European Region face a number of challenges before vaccine implementation, including strengthening surveillance, improving laboratory capacity and addressing financial barriers. IntroductionThe recent publication of the results of phase III trials of two oral rotavirus vaccines [1,2] showed vaccines that were effective in preventing serious clinical end points of rotavirus infection. The vaccines provide 85-95% protection against rotavirus infections severe enough to require hospitalisation, and 72-74% protection against all rotavirus infections [1,2]. However, vaccination appeared to protect only against disease, not to reduce the overall incidence of rotavirus gastrointestinal infection in the target group [2,...

show abstract

Human Rotavirus G9 and G3 as Major Cause of Diarrhea in Hospitalized Children, Spain

Abstract: A major shift in the predominant strains of rotavirus was detected.

Cited by 78 publications

References 23 publications

Rotavirus genotypes in children in the Basque Country (northern Spain) over a 13-year period (July 1996–June 2009)

Rotavirus genotypes in children in the Basque Country (northern Spain) over a 13-year period (July 1996–June 2009)

Detection of Rotavirus and Enteric Adenovirus Antigens in Outpatients with Gastroenteritis

Survey of rotavirus surveillance, laboratory capacity and disease burden in the eastern part of the WHO European Region

Contact Info

Product

Resources

About