Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis

Hu, Lei; Li, Xiangyun; Jing, Bo; Xu, Hanzhang; Wu, Yingli

doi:10.1371/journal.pone.0169788

Cited by 25 publications

(15 citation statements)

References 45 publications

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“…The main role of calpain is the regulation of various fundamental cellular functions, such as the cell cycle and apoptosis, but it is also involved in the initiation of inflammation by the degradation of IκB and the activation of NFκB [ 56 ]. An increase in the level of calpain in psoriatic patients has already been identified in the skin tissue [ 57 , 58 ]. However, calpain also stimulates the migration of fibroblasts and myoblasts, which is necessary for the treatment of damaged skin [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Gęgotek

Domingues

Wroński³

2020

IJMS

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The dermal fibroblasts are in constant contact with the cells of the immune system and skin epidermis. Therefore, they are essential for the development of lesions in psoriasis. The aim of this study was to assess the changes in the proteomic profile of fibroblasts in the dermis of psoriasis patients, and to discuss the most significant changes and their potential consequences. The proteomic results indicate that fibroblast dysfunction arises from the upregulation of proinflammatory factors and antioxidant proteins, as well as those involved in signal transduction and participating in proteolytic processes. Moreover, downregulated proteins in psoriatic fibroblasts are mainly responsible for the transcription/translation processes, glycolysis/ adenosine triphosphate synthesis and structural molecules. These changes can directly affect intercellular signaling and promote the hyperproliferation of epidermal cells. A better understanding of the metabolic effects of the proteomic changes observed could guide the development of new pharmacotherapies for psoriasis.

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Section: Discussionmentioning

confidence: 99%

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Gęgotek

Domingues

Wroński³

2020

IJMS

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“…p38 is relatively inactive in the unphosphorylated form and can be activated rapidly by MAPK kinase-3 and -6 upon exposure to cellular stress or inflammatory cytokines (51)(52)(53). p38 signaling pathway induces the expression of MMPs and thereby promotes the degradation of ECM proteins, leading to cell invasion (54).…”

Section: Discussionmentioning

confidence: 99%

Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway

Zhou

Cai

2017

Oncology Reports

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Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found that matrine significantly inhibited cervical cancer cell growth by inducing apoptosis, and suppressed the invasion and migration ability of cervical cancer cells in vitro in a concentration-dependent manner. Mechanistically, we found that matrine decreased the expression and activity of the extracellular matrix factors, matrix metalloproteinases-2 (MMP-2) and MMP-9 via the suppression of p38 signaling pathway. In addition, when cervical cancer cells were grown as xenografts in nude mice, intraperitoneal (i.p.) injection of matrine induced a signiﬁcant dose-dependent decrease in tumor growth. Taken together, these findings suggest that a potential mechanism by which matrine inhibits the growth and metastasis of cervical cancer through downregulating the p38 signaling pathway.

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“…31 It has also been demonstrated that MAPK p38 signalling might be involved in downstream signalling of RAGE activity connecting the AGE/RAGE signalling with pro-inflammatory response. 32,33 To summarize, NADPH-oxidase activity is enhanced by AGE-RAGE interaction and MAPK p38 signalling is activated, which contributes to the excessive inflammatory response. In atherosclerotic lesions, VECs and inflammatory cells can produce inflammatory cytokines including IL-1β and IL-6 in response to the initial injury of the vascular wall because of mechanical stress and deposition of ox-LDL.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Kappa‐light‐chain‐enhancer of activated B (NF‐κB, nuclear transcription factor) is activated by increased ROS, leading to pro‐inflammatory responses in the lesion area . It has also been demonstrated that MAPK p38 signalling might be involved in downstream signalling of RAGE activity connecting the AGE/RAGE signalling with pro‐inflammatory response . To summarize, NADPH‐oxidase activity is enhanced by AGE‐RAGE interaction and MAPK p38 signalling is activated, which contributes to the excessive inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

miR‐21‐3p regulates AGE/RAGE signalling and improves diabetic atherosclerosis

Shao

Zhao

et al. 2020

Cell Biochemistry & Function

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To explore the effects of miR-21-3p on diabetic atherosclerosis. Using enzyme-linked immunosorbent assay (ELISA), we also detected the levels of soluble receptor for advanced glycation endproducts RAGE (sRAGE) in the cellular supernatant of vascular endothelial cells after transfecting them with adenovirus vector having miR-21-3p mimic or inhibitor. We found decrease in the expression levels of miR-21-3p in vascular endothelial cells (VECs) induced by high-concentration glucose. We also observed that the introduction of miR-21-3p mimic significantly increased the expression of ADAM10 in the VECs. Similarly, significantly higher levels of sRAGE were found in the cultured supernatant after administration of miR-21-3p mimic in human vein endothelial cells. The production of reactive oxygen species and expression of inflammatory cytokines in VECs induced by LPS and high-concentration glucose were significantly decreased after administration of miR-21-3p. in vivo studies revealed that intravenous injection of miR-21-3p at regular intervals would reduce the area of atherosclerotic lesion and elevate the serum levels of sRAGE in atherosclerotic diabetic mice. miR-21-3p may be beneficial in diabetic atherosclerosis by promoting the cleaved form of sRAGE and inhibition of RAGE/NADPH oxidase signalling depending on the increased expression of ADAM10. Significance of the Study: We identified a novel microRNA, miR-21-3p, which is characteristically at elevated levels in serum derived from diabetic patients and responsible for target degradation of ADAM10 mRNA. Further, we show that miR-21-3p aggravates the atherosclerotic lesion via dysfunction of the ectodomain shedding of molecular binding RAGE in the diabetic atherosclerotic mice.

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Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis

Cited by 25 publications

References 45 publications

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway

miR‐21‐3p regulates AGE/RAGE signalling and improves diabetic atherosclerosis

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