This empirical study analyzes the relationship between economic growth, unemployment and poverty at provincial level in Vietnam. The study is conducted on a sample of 245 year observations in 63 Vietnam provinces for the period of 2012-2015. The research results show that: Firstly, public investment has a positive impact on economic growth. Secondly, poverty, and export & import have a negative impact on unemployment. Thirdly, public investment has a significant and positive impact on unemployment. Fourthly, unemployment; export & import; and public investment have a negative impact on poverty. On the basis of our findings, we suggest 03 groups of recommendations for sustainable economic growth, poverty reduction, and unemployment reduction of Vietnam provinces.