Human <scp>FOXP</scp>3<sup>+</sup> T regulatory cell heterogeneity

Mohr, Audrey; Malhotra, Rajneesh; Mayer, Gaëll; Gorochov, Guy; Miyara, Makoto

doi:10.1002/cti2.1005

Cited by 80 publications

(72 citation statements)

References 73 publications

(131 reference statements)

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“…Tregs play a pivotal role in maintaining immunological self‐tolerance and excessive immune responses by actively suppressing both self‐reactive and foreign antigen‐reactive lymphocytes . FoxP3‐expressing Tregs are not a homogeneous population . Recently, 22 distinct subpopulations of Tregs have been identified .…”

Section: Origin Diversity Function and Plasticity Of Regulatory T Cmentioning

confidence: 99%

“…19 FoxP3-expressing Tregs are not a homogeneous population. 20,21 Recently, 22 distinct subpopulations of Tregs have been identified. 21 CD4+ CD25+ FoxP3+ Tregs encompass two main categories of lymphocytes that are distinct in their origin, antigen specificity in addition to the stimuli driving their differentiation and homeostasis.…”

Section: Origin Diversity Function and Plasticity Of Regulatory T Cmentioning

confidence: 99%

See 1 more Smart Citation

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

et al. 2018

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Section: Origin Diversity Function and Plasticity Of Regulatory T Cmentioning

confidence: 99%

Section: Origin Diversity Function and Plasticity Of Regulatory T Cmentioning

confidence: 99%

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

et al. 2018

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“…In the present study, five markers were employed simultaneously to accurately define Treg cell phenotype. In fact, the combination of these markers was shown to better reflect Treg cell functions, which are enriched within the CD25hiCD127loFoxP3 + gated population (18). Finally, it is possible that the studied populations are somehow heterogeneous, as they differ in several factors, including sociodemographic and histological subtypes of NHL.…”

Section: Discussionmentioning

confidence: 99%

Levels of regulatory T cells and invariant natural killer cells and their associations with regulatory B�cells in patients with non-Hodgkin lymphoma

et al. 2018

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Due to their immunoregulatory properties, several specialized cell subsets, including regulatory T (Treg), invariant natural killer T (iNKT) and regulatory B (Breg) cells, are involved in the pathogenesis of non-Hodgkin lymphoma (NHL). However, the interaction between various cells remains to be elucidated. The aim of the present study was to evaluate the levels of Treg, iNKT and Breg cell subsets and their interrelationships in the peripheral blood (PB) and bone marrow (BM) of patients with B-cell NHL who received rituximab-based regimens and achieved a complete remission. A total of 20 patients and 20 healthy age-and sex-matched controls were prospectively enrolled for investigation of Treg, iNKT and Breg cell subsets in PB and BM by flow cytometry and cell culture. Prior to administration of combination chemotherapy with rituximab, the patients had lower levels of Breg cells and, to a lesser degree, Treg cells, but not iNKT cells, in PB compared with controls. Compartmental differences in the levels of Treg and Breg cell subsets, but not iNKT cells, were observed between PB and BM, suggesting an increase in trafficking through the blood of these regulatory cell subsets to the marrow. Following complete remission, the levels of circulating Treg, iNKT and Breg cell subsets increased. The levels of Treg cells were not significantly associated with iNKT and Breg cell subsets, although negative correlations were observed. Taken together, these results may provide new insights into the potential role of regulatory cell subsets in patients with B-cell NHL. However, whether the observed differences between PB and BM may affect clinical outcomes requires further investigation.

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“…There is increasing evidence that the human T regulatory population is highly heterogeneous in phenotype and function . While FOXP3‐expressing cells can be roughly separated into three subsets (naive T reg cells, effector T reg cells and FOXP3 lo ‐activated T cells) , there are novel data indicating that these subpopulations can be subdivided phenotypically even further (Fig.…”

Section: Heterogeneity Of Human Foxp3‐expressing Cd4+ T Cell Subsetsmentioning

confidence: 99%

The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases

Mohr

Atif

Balderas

et al. 2019

Clinical and Experimental Immunology

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CD4 + regulatory T cells (T reg ) expressing the forkhead box protein 3 (FOXP3)transcription factor (T regs ) are instrumental for the prevention of autoimmune diseases. There is increasing evidence that the human T regulatory population is highly heterogeneous in phenotype and function. Numerous studies conducted in human autoimmune diseases have shown that T reg cells are impaired either in their suppressive function, in number, or both. However, the contribution of the FOXP3 + T reg subpopulations to the development of autoimmunity has not been delineated in detail. Rare genetic disorders that involve deficits in T reg function can be studied to develop a global idea of the impact of partial or complete deficiency in a specific molecular mechanism involved in T reg function. In patients with reduced T reg numbers (but no functional deficiency), the expansion of autologous T reg cells could be a suitable therapeutic approach: either infusion of invitro autologous expanded cells, infusion of interleukin (IL)-2/anti-IL-2 complex, or both. T reg biology-based therapies may not be suitable in patients with deficits of T reg function, unless their deficit can be corrected in vivo/in vitro.Finally, it is critical to consider the appropriate stage of autoimmune diseases at which administration of T reg cellular therapy can be most effective. We discuss conflicting data regarding whether T reg cells are more effectual at preventing the initiation of autoimmunity, ameliorating disease progression or curing autoimmunity itself.

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Human FOXP3⁺ T regulatory cell heterogeneity

Cited by 80 publications

References 73 publications

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

Levels of regulatory T cells and invariant natural killer cells and their associations with regulatory B�cells in patients with non-Hodgkin lymphoma

The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases

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Human FOXP3+ T regulatory cell heterogeneity

Cited by 80 publications

References 73 publications

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

Levels of regulatory T cells and invariant natural killer cells and their associations with regulatory B�cells in patients with non-Hodgkin lymphoma

The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases

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Product

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Human FOXP3⁺ T regulatory cell heterogeneity